Brain asymmetries from mid- to late life and hemispheric brain age

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 1, 2024

Abstract The human brain demonstrates structural and functional asymmetries which have implications for ageing mental neurological disease development. We used a set of magnetic resonance imaging (MRI) metrics derived from diffusion MRI data in N =48,040 UK Biobank participants to evaluate age-related differences asymmetry. Most regional grey white matter presented asymmetry, were higher later life. Informed by these results, we conducted hemispheric age (HBA) predictions left/right multimodal metrics. HBA was concordant conventional predictions, using both hemispheres, but offers supplemental general marker asymmetry when setting into relationship with each other. In contrast WM asymmetries, discrepancies are lower at ages. Our findings outline various sex-specific differences, particularly important estimates, the value further investigating role

Язык: Английский

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In vivo Calcium Extrusion from Accumbal Astrocytes Reduces Anxiety-like Behaviors but Increases Compulsive-like Responses and Compulsive ethanol drinking in Mice

Neuropharmacology, Год журнала: 2025, Номер 268, С. 110320 - 110320

Опубликована: Янв. 20, 2025

Язык: Английский

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Outrunning a bad diet: Interactions between exercise and a Western-style diet for adolescent mental health, metabolism and microbes

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 149, С. 105147 - 105147

Опубликована: Март 27, 2023

Язык: Английский

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Molecular Regulation and Therapeutic Applications of Brain-Derived Neurotrophic Factor–Tropomyosin-Related Kinase B Signaling in Major Depressive Disorder Though Its Interaction with Vascular Endothelial Growth Factor and N-Methyl-D-Aspartic Acid Receptors: A Narrative Review

Biologics, Год журнала: 2025, Номер 5(1), С. 7 - 7

Опубликована: Март 3, 2025

The molecular regulation and therapeutic applications of brain-derived neurotrophic factor (BDNF)–tropomyosin-related kinase B (TrkB) signaling in major depressive disorder (MDD) through interaction with vascular endothelial growth (VEGF) N-methyl-D-aspartic acid (NMDA) receptors show promise. While BDNF-TrkB is implicated antidepressant action, the association between BDNFs depression has not yielded conclusive results. Some studies decreased BDNF levels depression, while others indicate that increased expression certain brain regions can induce susceptibility. role varies across different regions, necessitating further study individual mechanisms. This regional variability complicates development targeted therapies. antidepressant-like actions require VEGF signaling, but there also a reciprocal interdependence, as are dependent on BDNFs. complex relationship

Язык: Английский

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Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome

Biology, Год журнала: 2025, Номер 14(4), С. 363 - 363

Опубликована: Март 31, 2025

The excitation/inhibition (E/I) balance is a critical feature of neural circuits, which crucial for maintaining optimal brain function by ensuring network stability and preventing hyperexcitability. hippocampus exhibits the particularly interesting characteristics having different functions E/I profiles between its dorsal ventral segments. Furthermore, vulnerable to epilepsy implicated in Fragile X Syndrome (FXS), disorders associated with heightened possible deficits GABA-mediated inhibition. In epilepsy, shows susceptibility seizures, while FXS, recent evidence suggests differential alterations excitability inhibition regions. This article explores mechanisms underlying regulation, focusing on emphasizing that may confer homeostatic flexibility balance. Notably, adult FXS models enhanced GABAergic inhibition, resistance epileptiform activity, physiological pattern (sharp wave-ripples, SWRs), potentially representing adaptation. contrast, these more aberrant discharges displays altered SWRs. These findings highlight complex, region-specific nature disruptions neurological suggest possess unique compensatory mechanisms. Specifically, it proposed hippocampus, region most prone hyperexcitability, have adaptive capabilities at cellular levels maintain within normal range prevent transition hyperexcitability preserve function. Investigating responses their developmental trajectories offer novel insights into strategies mitigating imbalances other neuropsychiatric neurodevelopmental disorders.

Язык: Английский

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Unraveling the mechanisms of propofol-induced psychological dependence: a multi-omics approach linked to gut microbiota in hippocampal function

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 3, 2025

Drug abuse is becoming a global public health crisis. According to the United Nations, number of drug users worldwide has increased dramatically over past decade, with surge in abusers. The problem was exacerbated by expanding market for illicit drugs and increasing availability synthetic such as fentanyl. Clinical that requires particular attention, potential addictive properties some their mechanisms action are currently unknown, which limits development implementation addiction intervention strategies. Eight-week-old C57BL/6J mice were used study subjects. A mental dependence model established using conditional position preference experiment (CPP), hippocampal tissues subjected RNA-seq transcriptome sequencing, LC-MS non-targeted metabolome intestinal macro-genome sequencing order discover propofol signature genes. Correlation analyses transcriptomics metabolomics performed Spearman method, gene-metabolite networks mapped Cytoscape software. Real-time fluorescence quantitative PCR immunoprotein blotting (Western blotting) methods validate characterized After conditioned experiment, scores 75 mg/kg 2 g/kg alcohol groups significantly higher than those control saline group. 152 differential genes 214 metabolites identified Cluster analysis revealed changes neuroactive ligand receptor pathway most pronounced. Gut microbiomics assays significant five enterobacterial phyla (Campylobacter phylum, Thick-walled Anaplasma Actinobacteria Chlorella verticillata phylum) group, may be related expression dopamine. These findings suggest mind-dependent effect on biology through ligand-receptor interaction pathways conjunction tricarboxylic acid cycle, metabolic alanine, aspartate, glutamate influence microbial bidirectional signaling.

Язык: Английский

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Human Brain Magnetic Resonance Imaging Studies for Psychiatric Disorders: The Current Progress and Future Directions

JMA Journal, Год журнала: 2024, Номер 7(2), С. 197 - 204

Опубликована: Янв. 1, 2024

With the prevalence of psychiatric disorders and limitations diagnostic scheme treatment options these disorders, magnetic resonance imaging (MRI) studies play a significant role in uncovering pathological basis potentially using biological markers clinical settings. The use MRI research has grown over past three decades, current continues to provide an avenue guide development approaches therapeutic solutions. However, shortcomings derive not only from technical (i.e., range contrasts that probes or sensors can create) but also confounding factors methodological case-control for disorders. Thus, by reviewing recent literature on we explain progress brain methodologies used study We consider growing cross-disorder methods identify shared disease-specific features across In addition, need outline healthy developmental aging changes investigate disorder difference as deviation trajectory. Although have provided us with new insights, demarcation between based definitive set pathologies remains limited. This challenge disease stratification is further complicated presence multiple different sets

Язык: Английский

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Early Life Stress and Metabolic Plasticity of Brain Cells: Impact on Neurogenesis and Angiogenesis

Biomedicines, Год журнала: 2021, Номер 9(9), С. 1092 - 1092

Опубликована: Авг. 26, 2021

Early life stress (ELS) causes long-lasting changes in brain plasticity induced by the exposure to factors acting prenatally or early postnatal ontogenesis due hyperactivation of hypothalamic-pituitary-adrenal axis and sympathetic nervous system, development neuroinflammation, aberrant neurogenesis angiogenesis, significant alterations metabolism that lead neurological deficits higher susceptibility disorders later life. As a key component complex pathogenesis, ELS-mediated associate with mitochondrial dysfunction, loss appropriate mitochondria quality control dynamics, deregulation metabolic reprogramming. These mechanisms are particularly critical for maintaining pool cells within neurogenic angiogenic niches. In this review, we focus on energy related tightly coupled events healthy ELS-affected brain, new opportunities develop efficient therapeutic strategies aimed restore reduce ELS-induced impairments plasticity.

Язык: Английский

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Agomelatine attenuates alcohol craving and withdrawal symptoms by modulating the Notch1 signaling pathway in rats

Life Sciences, Год журнала: 2021, Номер 284, С. 119904 - 119904

Опубликована: Авг. 25, 2021

Язык: Английский

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How sleep disturbances affect internet gaming disorder: The mediating effect of hippocampal functional connectivity

Journal of Affective Disorders, Год журнала: 2021, Номер 300, С. 84 - 90

Опубликована: Дек. 21, 2021

Язык: Английский

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