Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Дек. 30, 2024
Язык: Английский
Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107621 - 107621
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Animals, Год журнала: 2024, Номер 14(10), С. 1509 - 1509
Опубликована: Май 20, 2024
This experiment was conducted to investigate the effect of three–way hybrid sheep and Hu on serum indicators, rumen fermentation, enzyme activity, microorganisms in sheep. Healthy similar birth weights from three groups (Hu, n = 11; Charolais × Australian White Hu, CAH, Dorper CDH, 11) were selected be fed by ewes until 45 days age. Subsequently, they weaned intensively underwent short–term fattening for 3 months along with male lambs intensively. During this period, watered ad libitum. Blood fluid collected analyzed indicators microorganisms, VFA, respectively, at end period. Compared lamb, offspring lamb showed significant improvements body weight, lactate dehydrogenase, creatinine content. However, there no immunity antioxidant indices. In addition, volatile fatty acid (VFA) molar concentration microcrystalline cellulose lipase content significantly lower compared but β–glucosidase, amylase, pepsin, VFA ratio not affected. 16S rRNA sequencing diversity analysis revealed that increased microbial ACE Chao1 indices lamb. Meanwhile, abundance Verrucomicrobiota Synergistota phylum level. Correlation Prevotella had highest proportion, while Rikenellaceae_RC9_gut_group correlated most closely others genus. The communities isovaleric proportion strongly correlated. differences correlations between isobutyric acid, butyric valeric content, their digestive enzymes. From functional enrichment analysis, it found progeny mainly enriched pyruvate metabolism, metabolism diverse environments, carbon quorum sensing pathways. contrast, primarily cysteine methionine, amino sugar nucleotide sugar, biosynthesis secondary metabolite These results suggest hybridization can play a role regulating organismal improve animal production performance influencing structure characteristics communities.
Язык: Английский
Процитировано
5
Trends in Parasitology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Investigative Dermatology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Dental Research, Год журнала: 2025, Номер unknown
Опубликована: Фев. 2, 2025
It has been questioned whether Streptococcus mutans can still be considered the major etiological agent for caries. The main argument is that most evidence based on single-species identification. composition of oral microbiome was not analyzed. This systemic review aims to assess prevalence and abundance S. in caries-active (CA) caries-free (CF) subjects clinical studies which investigated. Three databases (PubMed, Cochrane, Embase) were searched until May 22, 2023, eligible publications included CA CF reported detection both microbial community, using DNA-based methods. outcomes summarized further analyzed a random-effects model. Of 22 studies, 3 excluded due high risk bias. In remaining 19 16 mutans, 11 its relative abundance, 8 parameters. either similar ( n = 4) or higher than 12) group. all although values varied from 0.001% 5%. Meta-analysis confirmed significance these findings. summary community data did reveal other caries-associated bacterial genera/species mutans. conclusion, collected suggests strong association between caries experience. While cariogenic role ecosystem should recognized, actual function warrants exploration.
Язык: Английский
Процитировано
0
Process Safety and Environmental Protection, Год журнала: 2025, Номер unknown, С. 106931 - 106931
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Фев. 27, 2025
BNT162b2 immunogenicity wanes with time and we investigated association between gut microbiota longer-term immunogenicity. This cohort study prospectively recruited adult two-dose recipients from three vaccination centers in Hong Kong. Blood samples were collected at baseline day 180 after first dose, tested for neutralizing antibodies (NAb) against receptor-binding domain (RBD) of wild type SARS-CoV-2 virus using chemiluminescence immunoassay. Shotgun DNA metagenomic sequencing was performed to characterize stool microbiome. Baseline metabolites measured by gas liquid chromatography-tandem mass spectrometry (GC-MS/MS LC-MS/MS). Primary outcome persistent high NAb response (defined as top 25% level) 180. Putative bacterial species metabolic pathways identified linear discriminant analysis [LDA] effect size analysis. Multivariable logistic regression adjusting clinical factors used derive adjusted odds ratio (aOR) metabolites. Of 242 subjects (median age: 50.2 years [IQR:42.5-55.6]; male:85 [35.1%]), 61 (25.2%) high-responders while 33 (13.6%) extreme-high responders NAb≥200AU/mL). None had COVID-19 end study. Ruminococcus bicirculans (log10LDA score=3.65), Parasutterella excrementihominis (score=2.82) Streptococcus salivarius (score=2.31) enriched high-responders, Bacteroides thetaiotaomicron low-responders (score=-3.70). On multivariable analysis, (R. bicirculans-aOR: 1.87, 95% CI: 1.02-3.51; P. excrementihominis-aOR: 2.2, 1.18-4.18; S. salivarius-aOR: 2.09, 1.13-3.94) but not associated response. R. positively correlated most including superpathway L-cysteine biosynthesis (score=2.25) L-isoleucine I pathway (score=2.16) known benefit immune system. serum butyrate (aOR:10.00, CI:1.81-107.2) isoleucine (aOR:1.17, CI:1.04-1.35) significantly vaccine Certain species, associate
Язык: Английский
Процитировано
0
Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117983 - 117983
Опубликована: Март 1, 2025
Considering the sensitivity of rare microbial taxa to environmental disturbances and their critical roles in ecosystems, it is essential investigate how soil communities (particularly microbes) respond pesticide exposure. In this study, we found that thiazole pesticides significantly reduced severity potato common scab effectively disrupted pathogen's cell membrane integrity. Notably, hierarchical partitioning analysis indicated geocaulosphere constitute key clusters influencing disease incidence. Within bacterial molecular ecological networks, nodes corresponding these generally exhibited higher degrees compared those more abundant taxa. However, exposure number keystone substantially weakened hub status networks. These findings suggest that, although eradicate pathogens, they may also pose a non-negligible potential risk agricultural ecosystems.
Язык: Английский
Процитировано
0
Опубликована: Март 10, 2025
Parent-offspring interactions constitute the first contact of many newborns with their environment, priming community assembly microbes through priority effects. Early exposure to can have lasting influences on and functionality host’s microbiota, leaving a life-long imprint host health disease. Studies role played by parental care in microbial acquisition primarily focused humans hosts agricultural relevance. Anuran vertebrates offer opportunity examine composition across life stages as function investment. In this study, we investigate vertical transmission microbiota during poison frog (Family Dendrobatidae ), where fathers transport offspring piggyback-style from terrestrial clutches aquatic nurseries. We found that substantial bacterial colonization embryo begins after hatching vitelline envelope, emphasizing its potential barrier early development. Using laboratory cross-foster experiment, demonstrated frogs performing tadpole serve source skin for tadpoles back. To study how impacts communities an ecologically relevant setting, sampled sympatric species do or not exhibit natural habitat. more diverse associated transporting compared non-transporting frog. However, detected no difference degree similarity between adult microbiotas, based whether exhibits behavior not. field confirmed result persistent isolated taxa caregiver’s skin, albeit often at low prevalence. This is describe anuran amphibians, showing may mechanism microbes. Overall, these findings provide foundation further research order host-associated physiology.
Язык: Английский
Процитировано
0
Опубликована: Март 10, 2025
Parent-offspring interactions constitute the first contact of many newborns with their environment, priming community assembly microbes through priority effects. Early exposure to can have lasting influences on and functionality host’s microbiota, leaving a life-long imprint host health disease. Studies role played by parental care in microbial acquisition primarily focused humans hosts agricultural relevance. Anuran vertebrates offer opportunity examine composition across life stages as function investment. In this study, we investigate vertical transmission microbiota during poison frog (Family Dendrobatidae ), where fathers transport offspring piggyback-style from terrestrial clutches aquatic nurseries. We found that substantial bacterial colonization embryo begins after hatching vitelline envelope, emphasizing its potential barrier early development. Using laboratory cross-foster experiment, demonstrated frogs performing tadpole serve source skin for tadpoles back. To study how impacts communities an ecologically relevant setting, sampled sympatric species do or not exhibit natural habitat. more diverse associated transporting compared non-transporting frog. However, detected no difference degree similarity between adult microbiotas, based whether exhibits behavior not. field confirmed result persistent isolated taxa caregiver’s skin, albeit often at low prevalence. This is describe anuran amphibians, showing may mechanism microbes. Overall, these findings provide foundation further research order host-associated physiology.
Язык: Английский
Процитировано
0