Advances in Light-Responsive Smart Multifunctional Nanofibers: Implications for Targeted Drug Delivery and Cancer Therapy
Pharmaceutics,
Год журнала:
2024,
Номер
16(8), С. 1017 - 1017
Опубликована: Июль 31, 2024
Over
the
last
decade,
scientists
have
shifted
their
focus
to
development
of
smart
carriers
for
delivery
chemotherapeutics
in
order
overcome
problems
associated
with
traditional
chemotherapy,
such
as
poor
aqueous
solubility
and
bioavailability,
low
selectivity
targeting
specificity,
off-target
drug
side
effects,
damage
surrounding
healthy
tissues.
Nanofiber-based
systems
recently
emerged
a
promising
system
cancer
therapy
owing
unique
structural
functional
properties,
including
tunable
interconnected
porosity,
high
surface-to-volume
ratio
entrapment
efficiency
loading
capacity,
mass
transport
which
allow
controlled
targeted
delivery.
In
addition,
they
are
biocompatible,
biodegradable,
capable
surface
functionalization,
allowing
target-specific
release.
One
most
common
fiber
production
methods
is
electrospinning,
even
though
relatively
two-dimensional
(2D)
tightly
packed
structures
rates
limited
its
performance.
Forcespinning
an
alternative
spinning
technology
that
generates
high-throughput,
continuous
polymeric
nanofibers
3D
structures.
Unlike
forcespinning
fibers
by
centrifugal
forces
rather
than
electrostatic
forces,
resulting
significantly
higher
production.
The
functionalization
nanocarriers
on
can
result
anticancer
capabilities
be
activated
external
stimuli,
light.
This
review
addresses
current
trends
potential
applications
light-responsive
dual-stimuli-responsive
electro-
forcespun
therapy,
particular
emphasis
functionalizing
nanofiber
surfaces
developing
nano-in-nanofiber
emerging
dual-controlled
release
high-precision
tumor
targeting.
progress
prospective
diagnostic
therapeutic
discussed
context
combination
therapy.
Язык: Английский
Visualization of Light‐Induced Rotational Movement in Crystal: Exploring the Mechanism of Viologen‐Containing Molecular Machines
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Constructing
effective
light-driven
crystal
molecular
machines
and
exploring
their
mechanisms
of
movement
are
vital
for
the
development
machines.
These
explorations
afford
an
Mn2+
metal-organic
framework
(MOF)crystal,
marking
first
instance
a
viologen-containing
crystalline
MOF
capable
exhibiting
reversible
rotational
motion.
Structural
analysis
indicates
that
rotation
bipyridine
units
initiates
with
transformation
in
coordination
configuration
manganese
ion,
which
subsequently
alters
dihedral
angle
from
-6.7°
to
-46.8°.
This
is
facilitated
through
single
bond
involves
transition
state
approaching
0°
during
radical
phase
viologen.
result
not
only
elucidates
mechanism
by
photo-induced
electron
transfer
propels
controlled
biaryl
groups
within
MOFs
but
also
highlights
great
potential
as
Язык: Английский
Probing attosecond dynamics of chiral bound wave packets with an attoclock
Physical review. A/Physical review, A,
Год журнала:
2025,
Номер
111(3)
Опубликована: Март 31, 2025
Язык: Английский
Towards precision medicine using biochemically triggered cleavable conjugation
Communications Chemistry,
Год журнала:
2025,
Номер
8(1)
Опубликована: Апрель 2, 2025
Язык: Английский
Effect of Remote Silyl Groups on the Hydrolytic Stability and Rapid Photocleavage of Carbamates
Опубликована: Авг. 6, 2024
Photocleavable
molecules
are
widely
used
in
fields
such
as
materials
science
and
chemical
biology.
In
particular,
coumarin-based
photocleavable
indispensable
for
photomanipulation
techniques
biology
because
of
their
ability
to
flexibly
adjust
the
wavelength
photostimulation
through
straightforward
structural
modifications.
However,
traditional
have
several
limitations,
including
hydrolysis
aqueous
environments
susceptibility
intracellular
carboxylesterases.
Additionally,
substituting
bonds
these
enhance
hydrolytic
stability
often
decreases
photolysis
efficiency.
Herein,
we
proposed
a
novel
molecular
design
concept
that
introduces
silyl
group
into
at
position
remote
from
photolabile
bond,
creating
an
ideal
molecule
tools.
The
established
orbital
effect
remotely
introduced
improves
efficiency
molecules,
while
its
bulkiness
substantially
enhances
under
enzymatic
conditions.
Furthermore,
this
improvement
functionality
contributes
development
high-performance
protein-release
biomaterials.
Язык: Английский
Stimuli-responsive materials in oral diseases: a review
Clinical Oral Investigations,
Год журнала:
2024,
Номер
28(9)
Опубликована: Авг. 23, 2024
Язык: Английский
Light-Triggered Transformation of Stilbene Supramolecular Polymers: Thermodynamic versus Kinetic Control
Chemical Communications,
Год журнала:
2024,
Номер
60(65), С. 8585 - 8588
Опубликована: Янв. 1, 2024
Light-triggered
supramolecular
polymer
transformations
from
kinetic
to
thermodynamic
control
are
achieved
by
shifting
hydrogen
bonds
intra-
inter-complexation
modes
for
[2+2]
cycloadducts.
Язык: Английский
Review and Future Perspectives of Stimuli-Responsive Bridged Polysilsesquioxanes in Controlled Release Applications
Polymers,
Год журнала:
2024,
Номер
16(22), С. 3163 - 3163
Опубликована: Ноя. 13, 2024
Bridged
polysilsesquioxanes
(BPSs)
are
emerging
biomaterials
composed
of
synergistic
inorganic
and
organic
components.
These
materials
have
been
investigated
as
ideal
carriers
for
therapeutic
diagnostic
systems
their
favorable
properties,
including
excellent
biocompatibility,
physiological
inertia,
tunable
size
morphology,
extensive
design
flexibility
functional
groups
to
satisfy
diverse
application
requirements.
Stimuli-responsive
BPSs
can
be
activated
by
both
endogenous
exogenous
stimuli,
offering
a
precise,
safe,
effective
platform
the
controlled
release
various
targeted
therapeutics.
This
review
aims
provide
comprehensive
overview
stimuli-responsive
BPSs,
focusing
on
synthetic
strategies,
biodegradability,
while
critically
assessing
capabilities
in
response
specific
stimuli.
Furthermore,
practical
suggestions
future
perspectives
development
presented.
highlights
significant
role
advancing
biomedical
research.
Язык: Английский
Enhancing optical absorbance and accelerating rotational speed in molecular motors through oriented external electric fields
The Journal of Chemical Physics,
Год журнала:
2024,
Номер
161(21)
Опубликована: Дек. 2, 2024
Accelerating
the
rotational
speed
of
light-driven
molecular
motors
is
among
foremost
concerns
in
machine
research,
as
this
directly
influences
performance
a
motor.
Controlling
motor’s
rotation
crucial
for
practical
applications,
and
using
an
oriented
external
electric
field
(OEEF)
represents
feasible
method
to
achieve
objective.
We
have
investigated
impact
OEEF
on
optical
kinetic
properties
novel
π-donor/acceptor
di-substituted
motor,
R2,3-(NH2,
CHO).
employed
density
functional
theory
(DFT)
time-dependent
DFT
methods
analyze
electronic
excitation
thermal
isomerization
behavior.
Our
results
demonstrate
that
absorption
wavelength,
efficiency
rate
constant
reaction
can
be
adjusted
by
applying
OEEFs,
which
are
predictable
based
dipole
moment
polarizability
molecules
under
consideration.
In
particular,
we
observed
shift
wavelength
toward
longer
ranges,
enhancement
light
intensity,
acceleration
when
weak
positive
directional
CHO)
summary,
theoretical
study
highlights
potential
OEEFs
improving
motors.
Язык: Английский
Two-Dimensional Nanoarchitectonics with Fluorination and Alkylation on Photoresponsive Azobenzene Molecules Self-Assembled at the Solid Surface
The Journal of Physical Chemistry C,
Год журнала:
2024,
Номер
128(41), С. 17767 - 17773
Опубликована: Окт. 8, 2024
The
development
of
stimuli-responsive
molecular
electronic
devices
relies
on
a
comprehensive
understanding
the
nature
and
strength
interactions
that
govern
their
self-assembly
solid
surfaces.
Here,
we
report
spatially
resolved
two-dimensional
self-assemblies
fluorinated
azobenzene
derivatives
using
scanning
tunneling
microscopy
(STM)
highly
oriented
pyrolytic
graphite
substrate.
STM
images
show
fluorine-substituted
form
large-scale
monolayers
stabilized
by
intermolecular
hydrogen
halogen
bonding,
unlike
nonfluorinated
counterparts.
Incorporating
an
alkoxy
chain
into
molecule
changes
balance
molecule–molecule
molecule–substrate
introducing
stronger
coupling
due
to
van
der
Waals
interactions.
High-resolution
enable
us
observe
alkylation-induced
in
atom-specific
among
polar
atoms
F,
O,
N
cores
molecules.
Our
results
clearly
highlight
significance
minor
chemical
modifications
such
as
fluorination
alkylation
adjusting
achieve
precise
packing
supports.
Язык: Английский