Journal of Affective Disorders, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Journal of Affective Disorders, Год журнала: 2022, Номер 321, С. 167 - 181
Опубликована: Окт. 28, 2022
This meta-analysis and systematic review aimed to evaluate the global prevalence risk factors of mental problems (i.e., depression, anxiety, stress, sleep disorder, posttraumatic stress disorder (PTSD), burnout, psychological distress, suicidal ideation) among medical students during COVID-19 pandemic. We searched PubMed, Embase, Web Science, psycARTICLES, PsycINFO, CNKI, Wan Fang for studies on from January 1, 2020, April 2022. The pooled was calculated by random-effect models. performed a narrative identify factors. included 201 (N = 198,000). depression (41 %, 95 % CI, 37–45 %,), anxiety (38 %,95 34 %–42 %), (34 27 (52 44 %–60 distress (58 51 %–65 PTSD 22 %–46 ideation (15 11 %–18 %) burnout 25 %–50 high. major were being female, junior or preclinical students, exposure COVID-19, academic psychiatric physical disorders history, economic trouble, fear education impairment, online learning infection, loneliness, low activity, social support, problematic internet smartphone use, young age. Most cross-sectional. Few provided reasonable response rate, suggesting potential selection bias. study demonstrated high calling health services. Our findings are valuable college authorities high-risk provide targeted intervention.
Язык: Английский
Процитировано
159
Journal of Infection and Public Health, Год журнала: 2023, Номер 16(5), С. 660 - 672
Опубликована: Март 7, 2023
Millions of COVID-19 pediatric survivors are facing the risk long COVID after recovery from acute COVID-19. The primary objective this study was to systematically review available literature and determine pooled prevalence of, factors for among survivors.
Язык: Английский
Процитировано
103
Molecular Psychiatry, Год журнала: 2023, Номер 28(4), С. 1793 - 1801
Опубликована: Янв. 23, 2023
Язык: Английский
Процитировано
66
Molecular Psychiatry, Год журнала: 2023, Номер 28(9), С. 3625 - 3637
Опубликована: Сен. 1, 2023
Abstract The human body harbors a diverse ecosystem of microorganisms, including bacteria, viruses, and fungi, collectively known as the microbiota. Current research is increasingly focusing on potential association between microbiota various neuropsychiatric disorders. resides in parts body, such oral cavity, nasal passages, lungs, gut, skin, bladder, vagina. gut gastrointestinal tract has received particular attention due to its high abundance role psychiatric neurodegenerative However, presents other tissues, though less abundant, also plays crucial immune system homeostasis, thus influencing development progression For example, imbalance associated periodontitis might increase risk for Additionally, studies using postmortem brain samples have detected widespread presence bacteria brains patients with Alzheimer’s disease. This article provides an overview emerging host disorders discusses future directions, underlying biological mechanisms, reliable biomarkers microbiota, microbiota-targeted interventions, this field.
Язык: Английский
Процитировано
50
JAMA Network Open, Год журнала: 2025, Номер 8(1), С. e2452789 - e2452789
Опубликована: Янв. 7, 2025
Importance Amid escalating mental health challenges among young individuals, intensified by the COVID-19 pandemic, analyzing postpandemic trends is critical. Objective To examine care utilization and prescription rates for children, adolescents, adults before after pandemic. Design, Setting, Participants This population-based time trend study used an interrupted series analysis to patterns French population 25 years younger. Aggregated data from national insurance database January 2016 June 2023. Data were analyzed September 2023 February 2024. Main Outcomes Measures The number of individuals with at least 1 outpatient psychiatric consultation, those admitted full-time hospitalization, a suicide attempt, receiving psychotropic medication was computed. stratified age groups sex. Quasi-Poisson regression modeled deseasonalized data, estimating relative risk (RR) 95% CI differences in slopes Results included approximately 20 million younger (20 829 566 697 169 2022). In 2016, consisted 10 208 277 female participants (49.0%) 6 091 959 (29.2%) aged 18 years. Proportions similar 2022. Significant increases observed compared prepandemic period, especially females people 13 older. Outpatient consultations increased women (RR, 1.13; CI, 1.07-1.20), 17 1.15; 1.06-1.23), 1.08; 1.03-1.14). Hospitalizations attempt 1.14; 1.02-1.27) 1.07; 1.03-1.12). Regarding medications, almost all classes, except hypnotics, prescriptions between 2022 females, particularly marked rise period. For men, only antidepressants 1.03; 1.01-1.06), methylphenidate 1.09; 1.06-1.12), medications prescribed alcohol use disorders 1.04-1.13) observed, these less pronounced than (antidepressant: RR, 1.13, 1.09-1.16; methylphenidate: 1.13-1.18; dependence: 1.12; 1.08-1.16). Medications reserved severe situations, such as lithium or clozapine, more frequently starting Conclusions Relevance this study, time-series found deterioration France accentuating that already
Язык: Английский
Процитировано
2
Journal of Biomedical Science, Год журнала: 2023, Номер 30(1)
Опубликована: Янв. 28, 2023
Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression treatment, which aggravates hinders treatment effects. Recent studies have shown that chronic stress-regulated systems secret to activate many signaling pathways related tumor development cells. The activated system acts not only on cells but also modulates survival metabolic changes surrounding non-cancerous Current clinical evidences suggest affects outcome cancer treatment. However, clinic, there is lack effective for patients. In this review, we discuss main mechanisms by regulates microenvironment, including functional regulation (stem cell-like properties, metastasis, angiogenesis, DNA damage accumulation, apoptotic resistance), reprogramming immune escape, peritumor neuromodulation. Based current framework stress, summarize pharmacological non-pharmacological therapeutic approaches provide some directions therapy.
Язык: Английский
Процитировано
29
Brain, Год журнала: 2023, Номер 146(6), С. 2241 - 2247
Опубликована: Фев. 2, 2023
Abstract Several large-scale electronic health records studies have reported increased diagnostic rates for neuropsychiatric disorders following Coronavirus disease 2019 [COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection)], but many questions remain. To highlight the issues, we selectively review this literature, focusing on mood disorder, anxiety psychotic and cognitive impairment (‘brain fog’). Eight key are addressed, comprising: (i) nature magnitude of risks; (ii) their association with severity infection; (iii) duration; (iv) whether risks differ between adults children, men women; (v) prior vaccination protects against them; (vi) risk profile associated different SARS-CoV-2 strains; (vii) what underlying mechanisms might be; (viii) sequelae can be predicted. We consider major unknowns, limitations research in area, use additional approaches to help characterize understand burden COVID-19.
Язык: Английский
Процитировано
25
Cell Reports Medicine, Год журнала: 2024, Номер 5(11), С. 101798 - 101798
Опубликована: Окт. 30, 2024
Язык: Английский
Процитировано
12
BMC Public Health, Год журнала: 2024, Номер 24(1)
Опубликована: Фев. 13, 2024
The COVID-19 pandemic has triggered a global mental health crisis. Yet, we know little about the lasting effects of infection on health. This prospective longitudinal study aimed to investigate trajectories changes in individuals infected with and identify potential predictors that may influence these changes.
Язык: Английский
Процитировано
11
Translational Psychiatry, Год журнала: 2024, Номер 14(1)
Опубликована: Авг. 4, 2024
The concept of a healthy lifestyle is receiving increasing attention. This study sought to identify an optimal profile associated with sleep health in general population China. An online cross-sectional survey was conducted from June July 2022. Six factors were assessed: diet, regular physical exercise, never smoking, drinking alcohol, low sedentary behavior, and normal weight. Participants categorized into the (5-6 factors), average (3-4 unhealthy groups (0-2 factors). study's primary outcome health, which included quality, duration, pattern, presence any disorder or disturbance, including insomnia, excessive daytime sleepiness, obstructive apnea syndrome, narcolepsy. Multivariable logistic regression analysis applied explore lifestyles selected outcomes. 41,061 individuals included, forming 18.8% healthy, 63.8% average, 17.4% groups. After adjusting for covariates, participants higher likelihood good quality (OR = 1.56, 95% CI 1.46-1.68), duration 1.60, 1.49-1.72), pattern 2.15, 2.00-2.31), lower risks insomnia 0.66, 0.61-0.71), sleepiness 0.60-0.73), syndrome 0.40, 0.37-0.43), but not narcolepsy 0.92, 0.83-1.03), compared those lifestyle. large first our knowledge quantify associations specific aspects health. findings offer support efforts improve by modulating
Язык: Английский
Процитировано
11