Allergy,
Год журнала:
2022,
Номер
77(11), С. 3185 - 3198
Опубликована: Июль 8, 2022
Abstract
Microbial
metabolism
of
specific
dietary
components,
such
as
fiber,
contributes
to
the
sophisticated
inter‐kingdom
dialogue
in
gut
that
maintains
a
stable
environment
with
important
beneficial
physiological,
metabolic,
and
immunological
effects
on
host.
Historical
changes
fiber
intake
may
be
contributing
increase
allergic
hypersensitivity
disorders
fiber‐derived
metabolites
are
evolutionarily
hardwired
into
molecular
circuitry
governing
immune
cell
decision‐making
processes.
In
this
review,
we
highlight
importance
ingredient,
its
microbiome,
regulation,
appropriate
timing
intervention
target
any
potential
window
opportunity,
mechanisms
for
fibers
prevention
management
diseases.
addition,
review
human
studies
examining
or
prebiotic
interventions
asthma
respiratory
outcomes,
rhinitis,
atopic
dermatitis,
overall
risk
disorders.
While
exposures,
interventions,
outcomes
were
too
heterogeneous
meta‐analysis,
there
is
significant
using
targeted
manipulations
microbiome
metabolic
functions
promoting
health.
Pediatric Gastroenterology Hepatology & Nutrition,
Год журнала:
2022,
Номер
25(3), С. 194 - 194
Опубликована: Янв. 1, 2022
Human
milk
contains
a
number
of
nutritional
and
bioactive
molecules
including
microorganisms
that
constitute
the
so-called
"Human
Milk
Microbiota
(HMM)".Recent
studies
have
shown
not
only
bacterial
but
also
viral,
fungal,
archaeal
components
are
present
in
HMM.Previous
research
has
established,
"core"
microbiome,
consisting
Firmicutes
(i.e.,
Streptococcus,
Staphylococcus),
Proteobacteria
Serratia,
Pseudomonas,
Ralstonia,
Sphingomonas,
Bradyrhizobium),
Actinobacteria
Propionibacterium,
Corynebacterium).This
review
aims
to
summarize
main
characteristics
HMM
role
it
plays
shaping
child's
health.We
reviewed
most
recent
literature
on
topic
(2019-2021),
using
PubMed
database.The
sources
origin
were
identified
as
retrograde
flow
entero-mammary
pathway.Several
factors
can
influence
its
composition,
such
maternal
body
mass
index
diet,
use
antibiotics,
time
type
delivery,
mode
breastfeeding.The
COVID-19
pandemic,
by
altering
mother-infant
dyad
modifying
many
our
previous
habits,
emerged
new
risk
factor
for
modification
HMM.HMM
is
an
important
contributor
gastrointestinal
colonization
children
therefore,
fundamental
avoid
any
form
perturbation
alter
microbial
equilibrium,
especially
first
100
days
life.Microbial
dysbiosis
be
trigger
point
development
necrotizing
enterocolitis,
preterm
infants,
onset
chronic
diseases,
asthma
obesity,
later
life.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
155, С. 113810 - 113810
Опубликована: Окт. 8, 2022
The
human
gut
microbiota
is
a
complex
ecosystem
involved
in
the
metabolism,
immunity,
and
health
of
host.
microbiome
plays
key
role
development
host's
innate
adaptive
immune
system,
while
system
orchestrates
maintenance
host-microbe
symbiosis.
Lung
diseases
are
usually
accompanied
by
dysbiosis
intestinal
flora
an
immune-inflammatory
response.
its
metabolites
directly
or
indirectly
regulation
host
lung
disease.
However,
exact
mechanism
action
gut-lung
axis
crosstalk
remains
unclear.
This
review
aimed
to
summarize
latest
advances
their
typical
diseases,
such
as
pulmonary
hypertension,
COPD,
cancer.
Especially
COVID-19,
problem
troubling
world,
also
discussed
it.
Moreover,
it
concentrated
on
mechanisms
between
identified
specific
link
among
microbiota,
metabolites,
regulation,
which
could
be
used
breakthrough
find
new
targets
for
some
without
therapeutic
drugs
clinic.
It
tool
"drug-bacterial
interaction"
potential
applications
would
provide
clear
direction
future
research
propose
strategy
targeting
Nature Immunology,
Год журнала:
2022,
Номер
23(12), С. 1687 - 1702
Опубликована: Дек. 1, 2022
Aside
from
centrally
induced
trained
immunity
in
the
bone
marrow
(BM)
and
peripheral
blood
by
parenteral
vaccination
or
infection,
evidence
indicates
that
mucosal-resident
innate
immune
memory
can
develop
via
a
local
inflammatory
pathway
following
mucosal
exposure.
However,
whether
results
integrating
distally
generated
immunological
signals
vaccination/infection
is
unclear.
Here
we
show
subcutaneous
Bacillus
Calmette-Guérin
(BCG)
induce
alveolar
macrophages
(AMs)
lung.
Although
BCG
trains
BM
progenitors
circulating
monocytes,
induction
of
AMs
independent
monocytes.
Rather,
vaccination,
mycobacterial
dissemination,
causes
time-dependent
alteration
intestinal
microbiome,
barrier
function
microbial
metabolites,
subsequent
changes
lung
leading
to
These
data
identify
an
microbiota-mediated
for
development
at
distal
tissues
have
implications
next-generation
vaccine
strategies
against
respiratory
pathogens.
Allergy,
Год журнала:
2022,
Номер
77(11), С. 3185 - 3198
Опубликована: Июль 8, 2022
Abstract
Microbial
metabolism
of
specific
dietary
components,
such
as
fiber,
contributes
to
the
sophisticated
inter‐kingdom
dialogue
in
gut
that
maintains
a
stable
environment
with
important
beneficial
physiological,
metabolic,
and
immunological
effects
on
host.
Historical
changes
fiber
intake
may
be
contributing
increase
allergic
hypersensitivity
disorders
fiber‐derived
metabolites
are
evolutionarily
hardwired
into
molecular
circuitry
governing
immune
cell
decision‐making
processes.
In
this
review,
we
highlight
importance
ingredient,
its
microbiome,
regulation,
appropriate
timing
intervention
target
any
potential
window
opportunity,
mechanisms
for
fibers
prevention
management
diseases.
addition,
review
human
studies
examining
or
prebiotic
interventions
asthma
respiratory
outcomes,
rhinitis,
atopic
dermatitis,
overall
risk
disorders.
While
exposures,
interventions,
outcomes
were
too
heterogeneous
meta‐analysis,
there
is
significant
using
targeted
manipulations
microbiome
metabolic
functions
promoting
health.
