The Role of Diet and Nutritional Interventions for the Infant Gut Microbiome

Nutrients, Год журнала: 2024, Номер 16(3), С. 400 - 400

Опубликована: Янв. 30, 2024

The infant gut microbiome plays a key role in the healthy development of human organism and appears to be influenced by dietary practices through multiple pathways. First, maternal diet during pregnancy nutrition significantly influence microbiota. Moreover, breastfeeding fosters proliferation beneficial bacteria, while formula feeding increases microbial diversity. timing introducing solid foods also influences microbiota composition. In preterm infants is factors, including time since birth intake breast milk, interventions such as probiotics prebiotics supplementation show promising results reducing morbidity mortality this population. These findings underscore need for future research understand long-term health impacts these further strategies enrich formula-fed infants.

Язык: Английский

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The role of animal hosts in shaping gut microbiome variation

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2024, Номер 379(1901)

Опубликована: Март 18, 2024

Millions of years co-evolution between animals and their associated microbial communities have shaped diversified the nature relationship. Studies continue to reveal new layers complexity in host–microbe interactions, fate which depends on a variety different factors, ranging from neutral processes environmental factors local dynamics. Research is increasingly integrating ecosystem-based approaches, metagenomics mathematical modelling disentangle individual contribution ecological microbiome evolution. Within this framework, host are known be among dominant drivers composition animal species. However, extent they shape assembly evolution remains unclear. In review, we summarize our understanding how drive these dynamics conserved vary across taxa. We conclude by outlining key avenues for research highlight need implementation modifications existing theory fully capture host-associated microbiomes. This article part theme issue ‘Sculpting microbiome: determine respond colonization’.

Язык: Английский

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Human Milk Microbiome—A Review of Scientific Reports

Nutrients, Год журнала: 2024, Номер 16(10), С. 1420 - 1420

Опубликована: Май 8, 2024

One of the most important bioactive components breast milk are free oligosaccharides, which a source energy for commensal intestinal microorganisms, stimulating growth Bifidobacterium, Lactobacillus, and Bacteroides in child’s digestive tract. There is some evidence that maternal, perinatal, environmental-cultural factors influence modulation microbiome. This review summarizes research has examined composition microbiome may it. The manuscript highlights potential importance future development health children. origin bacteria thought to include mother’s tract (entero-mammary tract), bacterial exposure during breastfeeding, retrograde flow from infant’s mouth woman’s ducts. Unfortunately, despite increasingly more precise methods assessing microorganisms human milk, topic still quite limited requires scientific takes into account various conditions.

Язык: Английский

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Breastfeeding and Health Benefits for the Mother-Infant Dyad: A Perspective on Human Milk Microbiota

Annals of Nutrition and Metabolism, Год журнала: 2025, Номер unknown, С. 1 - 13

Опубликована: Фев. 6, 2025

Background:: Current scientific research on breastfeeding provides substantial evidence of its numerous positive impacts, not only for children in both the short and long term but also mothers who engage breastfeeding. Summary:: In addition to gold standard effect human milk infant nutrition, is associated with a lower incidence infections, reduced infant/childhood mortality, necrotizing enterocolitis, obesity during childhood later life, better cognitive performance, higher IQ score. For mothers, prolongs lactational amenorrhea, may facilitate postpartum weight loss, reduce breast ovarian cancers cardiovascular diseases. Breastfeeding can play beneficial role preventing antibiotic resistance, which global concern across all age groups. Implementing exclusive infants has potential enhance child development decrease healthcare expenses, leading economic savings individual families society. Human biologically active food that functions as prebiotic probiotic because oligosaccharides composition microbiota, act synergistic synbiotics.

Язык: Английский

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Dysbiosis and extraintestinal cancers

Journal of Experimental & Clinical Cancer Research, Год журнала: 2025, Номер 44(1)

Опубликована: Фев. 7, 2025

Abstract The gut microbiota plays a crucial role in safeguarding host health and driving the progression of intestinal diseases. Despite recent advances remarkable correlation between dysbiosis extraintestinal cancers, underlying mechanisms are yet to be fully elucidated. Pathogenic microbiota, along with their metabolites, can undermine integrity barrier through inflammatory or metabolic pathways, leading increased permeability translocation pathogens. dissemination pathogens circulation may contribute establishment an immune-suppressive environment that promotes carcinogenesis organs either directly indirectly. oncogenic cascade always engages disruption hormonal regulation responses, induction genomic instability mutations, dysregulation adult stem cell proliferation. This review aims comprehensively summarize existing evidence points potential malignant transformation such as liver, breast, lung, pancreas. Additionally, we delve into limitations inherent current methodologies, particularly challenges associated differentiating low loads gut-derived microbiome within tumors from sample contamination symbiotic microorganisms. Although still controversial, understanding contribution translocated metabolites pathological continuum chronic inflammation could offer novel foundation for development targeted therapeutics.

Язык: Английский

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Gut–X axis

iMeta, Год журнала: 2025, Номер 4(1)

Опубликована: Фев. 1, 2025

Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.

Язык: Английский

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Exploring breast tissue microbial composition and the association with breast cancer risk factors

Breast Cancer Research, Год журнала: 2023, Номер 25(1)

Опубликована: Июль 10, 2023

Abstract Background Microbial dysbiosis has emerged as an important element in the development and progression of various cancers, including breast cancer. However, microbial composition from healthy individuals, even relative to risk developing cancer, remains unclear. Here, we performed a comprehensive analysis microbiota normal tissue, which was analyzed relation tumor adjacent tissue. Methods The study cohorts included 403 cancer-free women (who donated tissue cores) 76 cancer patients and/or samples). Microbiome profiling obtained by sequencing nine hypervariable regions 16S rRNA gene (V1V2, V2V3, V3V4, V4V5, V5V7, V7V9). Transcriptome also on 190 samples. Breast score assessed using Tyrer-Cuzick model. Results V1V2 amplicon resulted more suitable for microbiome identified Lactobacillaceae ( Firmicutes phylum), Acetobacterraceae , Xanthomonadaceae (both Proteobacteria phylum) most abundant families breast. Ralstonia both tumors histologically tissues malignant tumors. We conducted correlation between known factors. Abundances bacterial taxa Acetotobacter aceti Lactobacillus vini, paracase i, Xanthonomas sp. were associated with age p < 0.0001), racial background parity 0.0001). Finally, transcriptome showed enrichment metabolism- immune-related genes vini paracasei whereas presence linked dysregulation involved carbohydrate metabolic pathway. Conclusions This defines features thus providing basis understand cancer-related dysbiosis. Moreover, findings reveal that lifestyle factors can significantly affect composition.

Язык: Английский

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Gut‐lung axis and asthma: A historical review on mechanism and future perspective

Clinical and Translational Allergy, Год журнала: 2024, Номер 14(5)

Опубликована: Апрель 30, 2024

Abstract Background Gut microbiota are closely related to the development and regulation of host immune system by regulating maturation cells resistance pathogens, which affects immunity. Early use antibiotics disrupts homeostasis gut increases risk asthma. actively interact with via gut‐lung axis, a bidirectional communication pathway between lung. The manipulation through probiotics, helminth therapy, fecal transplantation (FMT) combat asthma has become hot research topic. Body This review mainly describes current pathogenesis asthma, role axis in Moreover, potential manipulating its metabolites as treatment strategy for been discussed. Conclusion effect on microecology imbalance contributes bacterial structural components metabolites. Asthma, turn, can also cause intestinal damage inflammation throughout body. FMT inform strategies pathogens.

Язык: Английский

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Smart Solutions for Diet-Related Disease Management: Connected Care, Remote Health Monitoring Systems, and Integrated Insights for Advanced Evaluation

Applied Sciences, Год журнала: 2024, Номер 14(6), С. 2351 - 2351

Опубликована: Март 11, 2024

The prevalence of diet-related diseases underscores the imperative for innovative management approaches. deployment smart solutions signifies a paradigmatic evolution, capitalising on advanced technologies to enhance precision and efficacy. This paper aims present explore diseases, focusing leveraging technologies, such as connected care, Internet Medical Things (IoMT), remote health monitoring systems (RHMS), address rising diseases. transformative approach is exemplified in case studies tailored RHMS capabilities. showcase potential three introducing novel evaluation method their customisation proactive conditions influenced by dietary habits. RO-SmartAgeing System uniquely addresses age-related aspects, providing an integrated that considers long-term impact choices ageing, marking perspective healthcare. NeuroPredict Platform, complex neuroinformatics, enhances understanding connections between brain health, nutrition, overall well-being, contributing insights healthcare assessments. Focused liver monitoring, HepatoConect system delivers real-time data personalized recommendations, offering distinctive disease management. By integrating cutting-edge these transcend traditional boundaries.

Язык: Английский

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Bovine milk microbiota: Key players, origins, and potential contributions to early-life gut development

Journal of Advanced Research, Год журнала: 2023, Номер 59, С. 49 - 64

Опубликована: Июль 7, 2023

Bovine milk is a significant substitute for human breast and holds great importance in infant nutrition health. Apart from essential nutrients, bovine also contains bioactive compounds, including microbiota derived itself rather than external sources of contamination. Recognizing the profound impact microorganisms on future generations, our review focuses exploring their composition, origins, functions, applications. Some primary found are present milk. These likely transferred to mammary gland through two pathways: entero-mammary pathway rumen-mammary pathway. We elucidated potential mechanisms by which contribute intestinal development. The include enhancing microecological niche, promoting maturation immune system, strengthening epithelial barrier function, interacting with components (e.g., oligosaccharides) via cross-feeding effect. However, given limited understanding microbiota, further studies necessary validate hypotheses regarding origins explore functions applications early

Язык: Английский

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