Journal of Pineal Research,
Год журнала:
2023,
Номер
75(1)
Опубликована: Апрель 14, 2023
It
is
widely
known
that
lack
of
sleep
damages
the
skin.
Therefore,
it
necessary
to
explore
relationship
between
deprivation
and
skin
damage
find
effective
treatments.
We
established
a
28-day
restriction
(SR)
mice
model
simulating
continuous
long-term
loss.
found
SR
would
barrier
function
mice's
skin,
cause
oxidative
stress
weaken
oscillations
skin's
biological
clock,
make
circadian
rhythm
Bacteroides
disappear.
The
short-chain
fatty
acids
(SCFA)
receptors
in
was
disordered.
After
melatonin
supplementation,
caused
by
improved,
clock
were
enhanced,
restored,
receptor
GPR43
propionic
acid
restored.
speculated
improving
effect
may
be
mediated
produced
gut
microbiota.
verified
vitro
could
improve
keratinocytes
damage.
then
consumed
microbiota
through
antibiotics
oral
not
Moreover,
supplementing
with
Our
research
showed
impaired
function.
Oral
restoring
its
metabolite.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Фев. 2, 2023
Short-chain
fatty
acids
(SCFAs)
are
metabolites
of
gut
microbes
that
can
modulate
the
host
inflammatory
response,
and
contribute
to
health
homeostasis.
Since
introduction
gut-skin
axis
concept,
link
between
SCFAs
skin
diseases
has
attracted
considerable
attention.
In
this
review,
we
have
summarized
literature
on
role
in
inflammation,
correlation
diseases,
especially
atopic
dermatitis,
urticaria,
psoriasis.
Studies
show
signaling
factors
alleviate
inflammation.
The
information
presented
review
provides
new
insights
into
molecular
mechanisms
driving
regulation,
along
with
possible
pathways
be
targeted
for
treatment
prevention
diseases.
Short-chain
fatty
acids
are
known
modulators
of
host-microbe
interactions
and
can
affect
human
health,
inflammation,
outcomes
microbial
infections.
Acetate
is
the
most
abundant
but
least
well-studied
these
modulators,
with
studies
focusing
on
propionate
butyrate,
which
considered
to
be
more
potent.
In
this
mini-review,
we
summarize
current
knowledge
acetate
as
an
important
anti-inflammatory
modulator
between
hosts
microorganisms.
This
includes
a
summary
pathways
by
metabolized
bacteria
cells,
functions
in
bacterial
impact
that
microbially
derived
has
immune
function.
Allergy,
Год журнала:
2024,
Номер
79(7), С. 1789 - 1811
Опубликована: Фев. 23, 2024
Abstract
We
performed
a
systematic
review
to
investigate
the
current
evidence
on
association
between
allergic
diseases
and
short
chain
fatty
acids
(SCFAs),
which
are
microbially
produced
suggested
as
one
mechanism
how
gut
microbiome
affects
risk
of
diseases.
Medline,
Embase
Web
Science
were
searched
from
data
inception
until
September
2022.
identified
37
papers,
17
investigated
prenatal
or
early
childhood
SCFAs
development
in
childhood,
20
assessed
patients
with
pre‐existing
Study
design,
study
populations,
outcome
definition,
analysis
method
reporting
results
varied
papers.
Overall,
there
was
some
showing
that
three
main
(acetate,
propionate
butyrate)
first
few
years
life
had
protective
effect
against
diseases,
especially
for
atopic
dermatitis,
wheeze
asthma
IgE‐mediated
food
allergy
childhood.
The
each
SCFA
disease
appeared
be
different
by
age
assessment.
Further
research
can
determine
potentially
timing
specific
will
useful
used
treatment
prevention
Abstract
Recent
advances
in
understanding
the
modulatory
functions
of
gut
and
microbiota
on
human
diseases
facilitated
our
focused
attention
contribution
to
pathophysiological
alterations
many
extraintestinal
organs,
including
liver,
heart,
brain,
lungs,
kidneys,
bone,
skin,
reproductive,
endocrine
systems.
In
this
review,
we
applied
“gut–X
axis”
concept
describe
linkages
between
other
organs
discussed
latest
findings
related
axis,”
underlying
mechanisms
potential
clinical
intervention
strategies.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3494 - 3494
Опубликована: Фев. 9, 2023
Dysbiosis
has
been
identified
in
many
dermatological
conditions
(e.g.,
psoriasis,
atopic
dermatitis,
systemic
lupus
erythematosus).
One
of
the
ways
by
which
microbiota
affect
homeostasis
is
through
microbiota-derived
molecules
(metabolites).
There
are
three
main
groups
metabolites:
short-chain
fatty
acids
(SCFAs),
tryptophan
metabolites,
and
amine
derivatives
including
trimethylamine
N-oxide
(TMAO).
Each
group
its
own
uptake
specific
receptors
these
metabolites
can
exert
their
function.
This
review
provides
up-to-date
knowledge
about
impact
that
gut
may
have
conditions.
Special
attention
paid
to
effect
microbial
on
immune
system,
changes
profile
cells
cytokine
disbalance,
characteristic
several
diseases,
especially
psoriasis
dermatitis.
Targeting
production
serve
as
a
novel
therapeutic
approach
immune-mediated
diseases.
