Circadian disruption and sleep disorders in neurodegeneration

Translational Neurodegeneration, Год журнала: 2023, Номер 12(1)

Опубликована: Фев. 13, 2023

Abstract Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions diseases. Circadian disruption disorders aggravate neurodegeneration in turn disrupt sleep. Importantly, various increase the risk Thus, harnessing biology findings from preclinical translational research is importance for reducing improving symptoms quality life individuals with via approaches that normalize context precision medicine. In this review, we discuss implications by summarizing both human animal studies, focusing on links prevalent forms neurodegeneration. These provide valuable insights into pathogenesis suggest promising role circadian-based interventions.

Язык: Английский

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The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications

Ageing Research Reviews, Год журнала: 2024, Номер 98, С. 102323 - 102323

Опубликована: Май 9, 2024

Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be maintained. In recent years, due to rise materials science, many bioactive functional have applied treatment combination drugs, satisfactory achieved. At present, research review antioxidant not complete. Based on existing studies, mechanism were summarized this paper, strategies based emerging reviewed.

Язык: Английский

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Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis

Nature Cancer, Год журнала: 2024, Номер 5(4), С. 546 - 556

Опубликована: Апрель 23, 2024

Язык: Английский

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Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health

Cells, Год журнала: 2024, Номер 13(2), С. 138 - 138

Опубликована: Янв. 11, 2024

A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, in contemporary society, there a prevalent occurrence misalignments system environmental cues, phenomenon frequently associated with adverse health consequences. The onset most current chronic diseases intimately connected alterations lifestyle practices under various facets, including following: reduced physical activity, exposure artificial light, also acknowledged as light pollution, sedentary behavior coupled consuming energy-dense nutriments, irregular eating frameworks, disruptions sleep patterns (inadequate quality duration), engagement shift work, known jetlag. rapid evolution life domestic routines has significantly outpaced rate genetic adaptation. Consequently, underlying rhythms exposed multiple shifts, thereby elevating susceptibility disease predisposition. comprehensive review endeavors synthesize existing empirical evidence that substantiates conceptual integration clock, biochemical molecular homeostasis, oxidative stress, stimuli imparted exercise, sleep, nutrition.

Язык: Английский

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Breast cancer: pathogenesis and treatments

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 18, 2025

Abstract Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes malignancy-related deaths in women. The increasingly nuanced molecular subtypes breast cancer have enhanced comprehension precision treatment this disease. mechanisms tumorigenesis progression been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, circadian rhythms. Technological advancements, particularly those integrated artificial intelligence, significantly improved accuracy detection diagnosis. emergence novel therapeutic concepts drugs represents a paradigm shift towards personalized medicine. Evidence suggests that optimal diagnosis models tailored individual patient risk expected are crucial, supporting era oncology for cancer. Despite rapid advancements increasing emphasis on clinical comprehensive update summary panoramic knowledge related disease needed. In review, we provide thorough overview global status including its epidemiology, factors, pathophysiology, subtyping. Additionally, elaborate latest research into contributing progression, emerging strategies, long-term management. This review offers valuable insights Cancer Research, thereby facilitating future progress both basic application.

Язык: Английский

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Basic helix–loop–helix ARNT like 1 regulates the function of immune cells and participates in the development of immune-related diseases

Burns & Trauma, Год журнала: 2025, Номер 13

Опубликована: Янв. 1, 2025

The circadian clock is an internal timekeeper system that regulates biological processes through a central and peripheral clocks controlling various genes. Basic helix-loop-helix ARNT-like 1 (BMAL1), also known as aryl hydrocarbon receptor nuclear translocator-like protein (ARNTL1), key component of the clock. deletion BMAL1 alone can abolish rhythms human body. plays critical role in immune cell function. Dysregulation linked to immune-related diseases such autoimmune diseases, infectious cancer, vice versa. This review highlights significant governing cells, including their development, differentiation, migration, homing, metabolism, effector functions. study explores how dysregulation have far-reaching implications potentially contribute onset sepsis, trauma. Furthermore, this discusses treatments for target disorders. Understanding impact on function provide insights into pathogenesis help development more effective treatment strategies. Targeting has been demonstrated achieve good efficacy indicating its promising potential targetable therapeutic these diseases.

Язык: Английский

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Melatonin Alleviates Circadian Rhythm Disruption‐Induced Enhanced Luteinizing Hormone Pulse Frequency and Ovarian Dysfunction

Journal of Pineal Research, Год журнала: 2025, Номер 77(1)

Опубликована: Янв. 1, 2025

Circadian rhythm disruption (CRD), stemming from sleep disorders and/or shift work, is a risk factor for reproductive dysfunction. CRD has been reported to disturb nocturnal melatonin signaling, which plays crucial role in female reproduction as circadian regulator and an antioxidant. The hypothalamic-pituitary-ovarian (HPO) axis regulates reproduction, with luteinizing hormone (LH) pulse pattern playing pivotal folliculogenesis steroidogenesis. However, the effect of on HPO involvement remains unclear. Female CBA/CaJ mice underwent modeling, involves alternating between standard light conditions 8-h advance schedule every 3 days 8 weeks, whereas control were maintained under 12:12-h light/dark (LD) cycle. Subsequent measurements diurnal levels, LH patterns assessments via serial tail-tip blood sampling evaluations ovarian function conducted. altered rhythms wheel-running activity secretion led augmented pattern, evidenced by increased frequency, mean pituitary beta-subunit (LHβ) expression, irregular estrous cycles, abnormal luteal function, endocrine oxidative stress. Melatonin treatment (10 mg/kg/day 4 weeks) significantly improved disorder mice, decreasing enhanced frequency LHβ expression. These findings further validated using vitro LβT2 cell perfusion model. Furthermore, restored scavenged reactive oxygen species, thereby preventing apoptosis preserving function. This study offers new insights into impact emphasizes potential supplementation mitigating its effects reproduction.

Язык: Английский

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Fasting: From Physiology to Pathology

Advanced Science, Год журнала: 2023, Номер 10(9)

Опубликована: Фев. 3, 2023

Overnutrition is a risk factor for various human diseases, including neurodegenerative metabolic disorders, and cancers. Therefore, targeting overnutrition represents simple but attractive strategy the treatment of these increasing public health threats. Fasting as dietary intervention combating has been extensively studied. practiced millennia, only recently have its roles in molecular clock, gut microbiome, tissue homeostasis function emerged. can slow aging most species protect against These centuried unfading adventures explorations suggest that fasting potential to delay help prevent treat diseases while minimizing side effects caused by chronic interventions. In this review, recent animal studies concerning role underlying mechanism physiology pathology are summarized, therapeutic highlighted, combination pharmacological discussed new regimen diseases.

Язык: Английский

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Physiological Rhythms and Biological Variation of Biomolecules: The Road to Personalized Laboratory Medicine

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6275 - 6275

Опубликована: Март 27, 2023

The concentration of biomolecules in living systems shows numerous systematic and random variations. Systematic variations can be classified based on the frequency as ultradian (<24 h), circadian (approximately 24 infradian (>24 which are partly predictable. Random biological known between-subject that among set points an analyte from different individuals within-subject variation, is variation around individuals' points. cannot predicted but estimated using appropriate measurement statistical procedures. Physiological rhythms analytes could considered essential elements predictive, preventive, particularly personalized laboratory medicine. This review aims to summarize research have been done about types physiological rhythms, variations, their effects tests. We searched PubMed Web Science databases for rhythm articles English without time restrictions with terms "Biological Within-subject Between-subject Ultradian Circadian rhythm, Infradian rhythms". It was concluded that, effective management predicting, preventing, personalizing medicine, safe valid interpretation patients' test results, both measurands should simultaneously.

Язык: Английский

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Using chronobiology-based second-generation artificial intelligence digital system for overcoming antimicrobial drug resistance in chronic infections

Annals of Medicine, Год журнала: 2023, Номер 55(1), С. 311 - 318

Опубликована: Янв. 3, 2023

Antimicrobial resistance results from the widespread use of antimicrobial agents and is a significant obstacle to effectiveness these agents. Numerous methods are used overcome this problem with moderate success. Besides efforts stewards, several artificial intelligence (AI)-based technologies being explored for preventing development. These first-generation systems mainly focus on improving patients' adherence. Chronobiology inherent in all biological systems. Host response infections pathogens activity assumed be affected by circadian clock. This paper describes reviews some current AI technologies. We present establishment second-generation chronobiology-based approach help further possibly existing resistance. An algorithm-controlled regimen that improves long-term developed based implementation variability dosing drug administration times. The method provides means ensuring sustainable improved outcomes. Ongoing clinical trials determine system chronic infections. Data studies expected shed light new aspect mechanisms suggest overcoming them.IMPORTANCE SECTIONThe presents resistance.Key messagesAntimicrobial agents.We

Язык: Английский

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