Progress in brain research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Advanced Science, Год журнала: 2023, Номер 10(9)
Опубликована: Фев. 3, 2023
Overnutrition is a risk factor for various human diseases, including neurodegenerative metabolic disorders, and cancers. Therefore, targeting overnutrition represents simple but attractive strategy the treatment of these increasing public health threats. Fasting as dietary intervention combating has been extensively studied. practiced millennia, only recently have its roles in molecular clock, gut microbiome, tissue homeostasis function emerged. can slow aging most species protect against These centuried unfading adventures explorations suggest that fasting potential to delay help prevent treat diseases while minimizing side effects caused by chronic interventions. In this review, recent animal studies concerning role underlying mechanism physiology pathology are summarized, therapeutic highlighted, combination pharmacological discussed new regimen diseases.
Язык: Английский
Процитировано
42
Journal of Religion and Health, Год журнала: 2023, Номер 63(5), С. 3329 - 3359
Опубликована: Дек. 18, 2023
Язык: Английский
Процитировано
30
Nutrients, Год журнала: 2024, Номер 16(17), С. 2878 - 2878
Опубликована: Авг. 28, 2024
As the population ages, promoting healthy aging through targeted interventions becomes increasingly crucial. Growing evidence suggests that dietary can significantly impact this process by modulating fundamental molecular pathways. This review focuses on potential of strategies in and mechanisms which specific nutrients patterns influence key pathways involved cellular repair, inflammation, metabolic regulation. Caloric restriction, intermittent fasting, Mediterranean diet, as well ketogenic diet showed promising effects aging, possibly mTORC1 AMPK, an insulin signaling pathway. By understanding intricate interplay between pathways, we develop personalized not only prevent age-related diseases, but also promote overall health well-being throughout process.
Язык: Английский
Процитировано
11
Obesity, Год журнала: 2025, Номер unknown
Опубликована: Фев. 4, 2025
Abstract Objective Both alternate‐day fasting (ADF) and calorie restriction (CR) are effective weight loss strategies. However, most individuals find it difficult to adhere CR. Furthermore, CR can induce an excessive of not only fat but also muscle mass. This study aimed compare the effects ADF pair‐feeding (PF) on metabolic pathways underlying obesity in mice with high‐fat diet (HFD)‐induced obesity. Methods Male C57BL/6N Tac ( n = 10 per group) were fed HFD for 8 weeks establish a diet‐induced model. Mice then continued either access food or PF next weeks. We measured body weight, adiposity, plasma biomarkers, molecular mechanisms involving lipolysis autophagy. Results resulted comparable loss. Compared PF, showed significant reduction liver hepatic triglyceride levels. significantly increased ketone levels white adipose tissue lipolysis. tended activate autophagy elongation autophagosome formation, which insignificant. Conclusions These findings indicated that is promising intervention diseases, potentially due its superior efficacy promoting ketogenesis compared PF.
Язык: Английский
Процитировано
2
Current Obesity Reports, Год журнала: 2025, Номер 14(1)
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
1
Frontiers in Nutrition, Год журнала: 2024, Номер 10
Опубликована: Янв. 17, 2024
Some studies have investigated the impact of intermittent fasting (IF) for patients with multiple sclerosis (MS). We aimed to conduct a comprehensive systematic review analyze and summarize all clinical concerning effects IF on MS. conducted an exhaustive information available in Embase, Cochrane, PubMed databases up until 1 September 2023. All research relating impacts MS were included. In total, this encompassed 5 studies, which included four RCTs one pilot study. Each study involved was assessed high quality. The results from these demonstrate that protocols could potentially serve as effective dietary strategy managing symptoms improving quality life individuals afflicted conclusion, might be potential beneficial intervention However, number trials field is relatively limited. large-scale investigate are urgently needed, may helpful manage intricate neuroimmune disorder. Systematic registration https://inplasy.com , identifier INPLASY2023100021.
Язык: Английский
Процитировано
9
Cell Reports Medicine, Год журнала: 2024, Номер 5(11), С. 101801 - 101801
Опубликована: Окт. 24, 2024
Язык: Английский
Процитировано
7
Advanced Science, Год журнала: 2023, Номер 11(11)
Опубликована: Дек. 25, 2023
Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including forces and properties, are sensed translated into biochemical signals. Increasing data demonstrate that mechanotransduction crucial for regulating macroscopic microscopic dynamics functionalities. However, the actions mechanisms of across multiple hierarchies, from molecules, subcellular structures, cells, tissues/organs, to whole-body level, have not been yet comprehensively documented. Herein, biological roles operational macro micro revisited, with focus on orchestrations diverse hierarchies. The implications, applications, challenges in human diseases also summarized discussed. Together, this knowledge hierarchical perspective has potential refresh insights regulation disease pathogenesis therapy, ultimately revolutionize prevention, diagnosis, treatment diseases.
Язык: Английский
Процитировано
14
Technology in Cancer Research & Treatment, Год журнала: 2024, Номер 23
Опубликована: Янв. 1, 2024
Treatment of triple-negative breast cancer (TNBC) remains challenging. Intermittent fasting (IF) has emerged as a promising approach to improve metabolic health various disorders. Clinical studies indicate IF is essential for TNBC progression. However, the molecular mechanisms underlying remodeling in regulating and progression are still unclear.
Язык: Английский
Процитировано
3
Metabolism, Год журнала: 2024, Номер 164, С. 156104 - 156104
Опубликована: Дек. 12, 2024
Язык: Английский
Процитировано
3