Nutrients,
Год журнала:
2023,
Номер
15(3), С. 734 - 734
Опубликована: Фев. 1, 2023
The
circadian
system
in
the
human
body
responds
to
daily
environmental
changes
optimise
behaviour
according
biological
clock
and
also
influences
various
physiological
processes.
suprachiasmatic
nuclei
are
located
anterior
hypothalamus
of
brain,
they
synchronise
24
h
light/dark
cycle.
Human
functions
highly
dependent
on
regulation
internal
clock.
Skeletal
muscles
comprise
largest
collection
peripheral
clocks
body.
Both
central
regulate
interaction
between
musculoskeletal
energy
metabolism.
skeletal
muscle
plays
a
vital
role
lipid
glucose
pathogenesis
osteoporosis
is
related
an
alteration
rhythm.
In
present
review,
we
discuss
disturbance
rhythm
its
resultant
effect
system.
We
nutritional
strategies
that
potentially
effective
maintaining
system's
homeostasis.
Active
collaborations
nutritionists
physiologists
field
chronobiological
chrononutrition
will
further
clarify
these
interactions.
This
review
may
be
necessary
for
successful
interventions
reducing
morbidity
mortality
resulting
from
disturbances.
Antioxidants,
Год журнала:
2022,
Номер
11(7), С. 1218 - 1218
Опубликована: Июнь 22, 2022
Light
pollution
is
one
of
the
most
serious
public
problems,
especially
night
light.
However,
effect
dim
blue
light
at
(dLAN-BL)
on
cognitive
function
unclear.
In
this
study,
we
evaluated
effects
exposure
to
dLAN-BL
in
C57BL/6J
mice
for
4
consecutive
weeks.
Our
results
showed
significantly
impaired
spatial
learning
and
memory
increased
plasma
corticosterone
level
mice.
Consistent
with
these
changes,
observed
numbers
activation
microglia
levels
oxidative
stress
product
MDA
hippocampus,
decreased
antioxidant
enzymes
Glutathione
peroxidase
(GSH-Px),
Superoxide
dismutase
(SOD),
Gluathione
reductase
(Gsr),
total
antioxidants
(T-AOC)
number
neurons
up-regulated
mRNA
expression
IL6,
TNF-α
protein
iNOS,
COX2,
TLR4,
p-p65,
Cleaved-Caspase3
BAX,
down-regulated
IL4,
IL10,
Psd95,
Snap25,
Sirt1,
Dcx
BCL2.
vitro
further
(10uM)-induced
BV2
cell
content
supernatant
p-p65
cells.
findings
suggested
hippocampal
activation,
which
turn
caused
neuroinflammation,
leading
neuronal
loss
synaptic
dysfunction,
ultimately
dysfunction
Biochemical Society Transactions,
Год журнала:
2022,
Номер
50(3), С. 1191 - 1204
Опубликована: Май 23, 2022
Lipids
comprise
a
diverse
group
of
metabolites
that
are
indispensable
as
energy
storage
molecules,
cellular
membrane
components
and
mediators
inter-
intra-cellular
signaling
processes.
Lipid
homeostasis
plays
crucial
role
in
maintaining
metabolic
health
mammals
including
human
beings.
A
growing
body
evidence
suggests
the
circadian
clock
system
ensures
temporal
orchestration
lipid
homeostasis,
perturbation
such
diurnal
regulation
leads
to
development
disorders
comprising
obesity
type
2
diabetes.
In
view
emerging
this
review,
we
summarize
current
knowledge
on
pathways
controlled
by
mammalian
system.
Furthermore,
review
connection
between
diseases
changes
belong
major
classes
lipids.
Finally,
highlight
mechanisms
underlying
organization
rhythms
upon
physiological
situation,
consequences
dysfunction
for
dysregulation
metabolism.
Annals of Medicine,
Год журнала:
2023,
Номер
55(1), С. 1262 - 1286
Опубликована: Март 28, 2023
Disturbed
circadian
rhythms
have
been
a
risk
factor
for
type
2
diabetes
mellitus
(T2DM).
Melatonin
is
the
major
chronobiotic
hormone
regulating
both
rhythm
and
glucose
homeostasis.
The
rs10830963
(G
allele)
of
melatonin
receptor
1B
(MTNR1B)
gene
has
strongest
genetic
associations
with
T2DM
according
to
several
genome-wide
association
studies.
MTNR1B
G
allele
also
associated
disturbed
phenotypes
altered
secretion,
factors
that
can
elevate
diabetes.
Furthermore,
evolutionary
studies
implied
presence
selection
pressure
ethnic
diversity
in
MTNR1B,
which
was
consistent
"thrifty
gene"
hypothesis
T2DM.
delayed
secretion
onset
dim-light
prolonged
duration
peak
melatonin.
This
may
help
human
ancestors
adapt
famine
or
food
shortages
during
long
nights
early
mornings
avoid
nocturnal
hypoglycemia
but
confers
susceptibility
due
adequate
energy
intake
modern
society.
We
provide
new
insight
into
role
variants
via
from
perspective
hypothesis;
these
data
indicate
novel
target
prevention
treatment
susceptible
populations
thrifty
genotype.
Nutrients,
Год журнала:
2023,
Номер
15(3), С. 734 - 734
Опубликована: Фев. 1, 2023
The
circadian
system
in
the
human
body
responds
to
daily
environmental
changes
optimise
behaviour
according
biological
clock
and
also
influences
various
physiological
processes.
suprachiasmatic
nuclei
are
located
anterior
hypothalamus
of
brain,
they
synchronise
24
h
light/dark
cycle.
Human
functions
highly
dependent
on
regulation
internal
clock.
Skeletal
muscles
comprise
largest
collection
peripheral
clocks
body.
Both
central
regulate
interaction
between
musculoskeletal
energy
metabolism.
skeletal
muscle
plays
a
vital
role
lipid
glucose
pathogenesis
osteoporosis
is
related
an
alteration
rhythm.
In
present
review,
we
discuss
disturbance
rhythm
its
resultant
effect
system.
We
nutritional
strategies
that
potentially
effective
maintaining
system's
homeostasis.
Active
collaborations
nutritionists
physiologists
field
chronobiological
chrononutrition
will
further
clarify
these
interactions.
This
review
may
be
necessary
for
successful
interventions
reducing
morbidity
mortality
resulting
from
disturbances.
