Advanced Drug Delivery Reviews,
Год журнала:
2024,
Номер
208, С. 115302 - 115302
Опубликована: Апрель 3, 2024
Cardiovascular
diseases
(CVDs)
stand
as
the
leading
cause
of
death
worldwide,
posing
a
significant
global
health
challenge.
Consequently,
development
innovative
therapeutic
strategies
to
enhance
CVDs
treatment
is
imperative.
RNA-based
therapies,
encompassing
non-coding
RNAs,
mRNA,
aptamers,
and
CRISPR/Cas9
technology,
have
emerged
promising
tools
for
addressing
CVDs.
However,
inherent
challenges
associated
with
RNA,
such
poor
cellular
uptake,
susceptibility
RNase
degradation,
capture
by
reticuloendothelial
system,
underscore
necessity
combining
these
therapies
effective
drug
delivery
systems.
Various
non-viral
systems,
including
extracellular
vesicles,
lipid-based
carriers,
polymeric
inorganic
nanoparticles,
well
hydrogels,
shown
promise
in
enhancing
efficacy
RNA
therapeutics.
In
this
review,
we
offer
an
overview
most
relevant
explored
emphasize
pivotal
role
systems
augmenting
their
effectiveness.
Additionally,
discuss
current
status
that
hinder
clinical
translation.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Авг. 6, 2022
Abstract
Recent
advancements
in
stem
cell
technology
open
a
new
door
for
patients
suffering
from
diseases
and
disorders
that
have
yet
to
be
treated.
Stem
cell-based
therapy,
including
human
pluripotent
cells
(hPSCs)
multipotent
mesenchymal
(MSCs),
has
recently
emerged
as
key
player
regenerative
medicine.
hPSCs
are
defined
self-renewable
types
conferring
the
ability
differentiate
into
various
cellular
phenotypes
of
body,
three
germ
layers.
MSCs
progenitor
possessing
self-renewal
(limited
vitro)
differentiation
potential
lineages,
according
International
Society
Cell
Gene
Therapy
(ISCT).
This
review
provides
an
update
on
recent
clinical
applications
using
either
or
derived
bone
marrow
(BM),
adipose
tissue
(AT),
umbilical
cord
(UC)
treatment
diseases,
neurological
disorders,
pulmonary
dysfunctions,
metabolic/endocrine-related
reproductive
skin
burns,
cardiovascular
conditions.
Moreover,
we
discuss
our
own
trial
experiences
targeted
therapies
setting,
propose
MSC
origin
concept
how
may
contribute
role
downstream
applications,
with
ultimate
objective
facilitating
translational
research
medicine
applications.
The
mechanisms
discussed
here
support
proposed
hypothesis
BM-MSCs
potentially
good
candidates
brain
spinal
injury
treatment,
AT-MSCs
disorder
regeneration,
UC-MSCs
disease
acute
respiratory
distress
syndrome
treatment.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 23, 2022
Considering
the
unique
therapeutic
potential
of
mesenchymal
stem
cells
(MSCs),
including
their
immunosuppressive
and
immunomodulatory
properties
as
well
ability
to
improve
tissue
regeneration,
these
have
attracted
attention
scientists
clinicians
for
treatment
different
inflammatory
immune
system
mediated
disorders.
However,
various
clinical
trials
using
MSCs
purpose
are
conflicting
differ
from
results
promising
preclinical
studies.
This
inconsistency
is
caused
by
several
factors
such
poor
migration
homing
capacities,
low
survival
rate,
level
proliferation
differentiation,
donor-dependent
variation
cells.
Enhancement
retention
persistent
effects
remain
a
challenge
overcome
in
MSC-based
therapy.
In
this
review,
we
summarized
approaches
enhance
outcomes
therapy
revised
current
future
perspectives
creation
cellular
products
with
improved
diverse
applications.
Abstract
In
recent
decades,
research
on
Extracellular
Vesicles
(EVs)
has
gained
prominence
in
the
life
sciences
due
to
their
critical
roles
both
health
and
disease
states,
offering
promising
applications
diagnosis,
drug
delivery,
therapy.
However,
inherent
heterogeneity
complex
origins
pose
significant
challenges
preparation,
analysis,
subsequent
clinical
application.
This
review
is
structured
provide
an
overview
of
biogenesis,
composition,
various
sources
EVs,
thereby
laying
groundwork
for
a
detailed
discussion
contemporary
techniques
preparation
analysis.
Particular
focus
given
state‐of‐the‐art
technologies
that
employ
microfluidic
non‐microfluidic
platforms
EV
processing.
Furthermore,
this
discourse
extends
into
innovative
approaches
incorporate
artificial
intelligence
cutting‐edge
electrochemical
sensors,
with
particular
emphasis
single
proposes
current
outlines
prospective
avenues
future
research.
The
objective
motivate
researchers
innovate
expand
methods
analysis
fully
unlocking
biomedical
potential.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Июль 25, 2024
Stem
cell-based
therapies
have
emerged
as
a
promising
approach
for
treating
various
neurological
disorders
by
harnessing
the
regenerative
potential
of
stem
cells
to
restore
damaged
neural
tissue
and
circuitry.
This
comprehensive
review
provides
an
in-depth
analysis
current
state
cell
applications
in
primary
conditions,
including
Parkinson's
disease
(PD),
Alzheimer's
(AD),
amyotrophic
lateral
sclerosis
(ALS),
multiple
(MS),
stroke,
spinal
cord
injury
(SCI),
other
related
disorders.
The
begins
with
detailed
introduction
biology,
discussing
types,
sources,
mechanisms
action
therapies.
It
then
critically
examines
preclinical
evidence
from
animal
models
early
human
trials
investigating
safety,
feasibility,
efficacy
different
such
embryonic
(ESCs),
mesenchymal
(MSCs),
(NSCs),
induced
pluripotent
(iPSCs).
While
ESCs
been
studied
extensively
models,
clinical
primarily
focused
on
adult
MSCs
NSCs,
well
iPSCs
their
derivatives.
We
assess
research
each
type,
highlighting
limitations
conditions.
synthesizes
key
findings
recent,
high-quality
studies
condition,
manufacturing,
delivery
methods,
therapeutic
outcomes.
replace
lost
neurons
directly
reconstruct
circuits
is
highlighted,
emphasizes
critical
role
paracrine
immunomodulatory
mediating
effects
most
article
also
explores
challenges
associated
translating
into
practice,
issues
sourcing,
scalability,
regulatory
considerations.
Furthermore,
it
discusses
future
directions
opportunities
advancing
treatments,
gene
editing,
biomaterials,
personalized
iPSC-derived
therapies,
novel
strategies.
concludes
emphasizing
transformative
revolutionizing
treatment
while
acknowledging
need
rigorous
trials,
standardized
protocols,
multidisciplinary
collaboration
realize
full
promise.
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 15, 2024
A
wound
takes
a
long
time
to
heal
and
involves
several
steps.
Following
tissue
injury,
inflammation
is
the
primary
cause
of
regeneration
repair
processes.
As
result,
pathophysiological
processes
involving
skin
damage,
healing,
remodeling
depend
critically
on
control
inflammation.
The
fact
that
it
feasible
target
for
improving
prognosis
healing
has
lately
become
clear.
Mesenchymal
stem
cells
(MSCs)
are
an
innovative
effective
therapeutic
option
due
their
immunomodulatory
paracrine
properties.
By
controlling
inflammatory
milieu
wounds
through
immunomodulation,
transplanted
MSCs
have
been
shown
speed
up
process.
In
addition
other
mechanisms,
including
handling
neutrophil
activity
modifying
macrophage
polarization,
there
may
be
modifications
activation
T
cells,
natural
killer
(NK)
dendritic
(DCs).
Furthermore,
studies
pretreating
improves
ability
modulate
immunity.
this
review,
we
summarize
existing
knowledge
about
how
influence
local
in
by
influencing
immunity
facilitate
We
also
provide
overview
optimizing
techniques
when
used
treat
wounds.
