Pharmaceuticals,
Год журнала:
2023,
Номер
16(4), С. 504 - 504
Опубликована: Март 28, 2023
Trimethylamine
N-oxide
(TMAO)
is
a
biologically
active
gut
microbiome-derived
dietary
metabolite.
Recent
studies
have
shown
that
high
circulating
plasma
TMAO
levels
are
closely
associated
with
diseases
such
as
atherosclerosis
and
hypertension,
metabolic
disorders
diabetes
hyperlipidemia,
contributing
to
endothelial
dysfunction.
There
growing
interest
understand
the
mechanisms
underlying
TMAO-induced
dysfunction
in
cardio-metabolic
diseases.
Endothelial
mediated
by
mainly
driven
inflammation
oxidative
stress,
which
includes:
(1)
activation
of
foam
cells;
(2)
upregulation
cytokines
adhesion
molecules;
(3)
increased
production
reactive
oxygen
species
(ROS);
(4)
platelet
hyperreactivity;
(5)
reduced
vascular
tone.
In
this
review,
we
summarize
potential
roles
inducing
leading
pathogenesis
progression
disease
conditions.
We
also
discuss
therapeutic
strategies
for
treatment
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
62(3)
Опубликована: Ноя. 11, 2022
The
inflammatory
microenvironment
involves
changes
in
pH
and
protein
phosphorylation
state
is
closely
related
to
the
occurrence
development
of
atherosclerosis
(AS).
Herein,
we
constructed
a
dual-detection
fluorescence
nanosensor
PCN-NP-HPZ
based
on
post
modification
MOFs,
which
realized
simultaneous
detection
imaging
through
pH-sensitive
group
piperazine
ZrIV
node
MOFs.
sensors
were
used
monitor
blood
phosphate
levels
at
different
time
stages
during
atherosclerotic
plaque
formation.
Two-photon
was
also
performed
vascular
endothelium.
Blood
tests
combined
with
two-photon
images
indicated
that
early
stage
AS,
tissue
lower
than
normal
mice,
while
higher
mice.
present
study
provides
new
analysis
method
for
assessment
disease.
Advanced Drug Delivery Reviews,
Год журнала:
2023,
Номер
194, С. 114709 - 114709
Опубликована: Янв. 20, 2023
Atherosclerosis,
a
chronic
cardiovascular
disease
caused
by
plaque
development
in
arteries,
remains
leading
cause
of
morbidity
and
mortality.
Atherosclerotic
plaques
are
characterized
the
expression
regulation
key
molecules
such
as
cell
surface
receptors,
cytokines,
signaling
pathway
proteins,
potentially
facilitating
precise
diagnosis
treatment
on
molecular
level
specifically
targeting
characteristic
molecules.
In
this
review,
we
highlight
recent
progress
past
five
years
developing
molecularly
targeted
nanomedicine
for
imaging
detection
atherosclerosis
with
use
inorganic
nanoparticles.
Through
delivery
contrast
nanoparticles
to
specific
atherogenesis,
atherosclerotic
at
different
stages
could
be
identified
monitored
via
various
modalities.
We
also
review
therapeutic
approaches
that
target
regulate
associated
lipid
regulation,
inflammation,
apoptosis.
The
is
concluded
discussion
current
challenges
future
treatment.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13434 - 13434
Опубликована: Авг. 30, 2023
Atherosclerosis
is
one
of
the
most
fatal
diseases
in
world.
The
associated
thickening
arterial
wall
and
its
background
consequences
make
it
a
very
composite
disease
entity
with
many
mechanisms
that
lead
to
creation.
It
an
active
process,
scientists
from
various
branches
are
engaged
research,
including
molecular
biologists,
cardiologists,
immunologists.
This
review
summarizes
available
information
on
pathophysiological
implications
atherosclerosis,
focusing
endothelium
dysfunction,
inflammatory
factors,
aging,
uric
acid,
vitamin
D,
miRNA
expression
as
recent
evidence
interactions
cellular
elements.
Analyzing
new
discoveries
for
underlying
causes
this
condition
assists
general
research
improve
understanding
mechanism
pathophysiology
thus
prevention
cardiovascular
diseases.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(4), С. 504 - 504
Опубликована: Март 28, 2023
Trimethylamine
N-oxide
(TMAO)
is
a
biologically
active
gut
microbiome-derived
dietary
metabolite.
Recent
studies
have
shown
that
high
circulating
plasma
TMAO
levels
are
closely
associated
with
diseases
such
as
atherosclerosis
and
hypertension,
metabolic
disorders
diabetes
hyperlipidemia,
contributing
to
endothelial
dysfunction.
There
growing
interest
understand
the
mechanisms
underlying
TMAO-induced
dysfunction
in
cardio-metabolic
diseases.
Endothelial
mediated
by
mainly
driven
inflammation
oxidative
stress,
which
includes:
(1)
activation
of
foam
cells;
(2)
upregulation
cytokines
adhesion
molecules;
(3)
increased
production
reactive
oxygen
species
(ROS);
(4)
platelet
hyperreactivity;
(5)
reduced
vascular
tone.
In
this
review,
we
summarize
potential
roles
inducing
leading
pathogenesis
progression
disease
conditions.
We
also
discuss
therapeutic
strategies
for
treatment
