Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Год журнала: 2023, Номер 17(15), С. 14347 - 14405

Опубликована: Июль 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Язык: Английский

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Recent advances in metal-organic frameworks: Synthesis, application and toxicity

The Science of The Total Environment, Год журнала: 2023, Номер 902, С. 165944 - 165944

Опубликована: Авг. 4, 2023

Язык: Английский

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Fluorescent Probes for Disease Diagnosis

Chemical Reviews, Год журнала: 2024, Номер 124(11), С. 7106 - 7164

Опубликована: Май 17, 2024

The identification and detection of disease-related biomarkers is essential for early clinical diagnosis, evaluating disease progression, the development therapeutics. Possessing advantages high sensitivity selectivity, fluorescent probes have become effective tools monitoring active molecules at cellular level in vivo. In this review, we describe current designed quantification key bioactive associated with common diseases, such as organ damage, inflammation, cancers, cardiovascular brain disorders. We emphasize strategies behind design capable biomarker diagnosis cover some aspects combined diagnostic/therapeutic based on regulating molecules. This review concludes a discussion challenges outlook probes, highlighting future avenues research that should enable these to achieve accurate biomedical applications.

Язык: Английский

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A two-pronged detection of atherosclerosis with a dual-channel fluorescent probe for viscosity and hypochlorous acid

Chemical Engineering Journal, Год журнала: 2023, Номер 464, С. 142687 - 142687

Опубликована: Март 29, 2023

Язык: Английский

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In Vivo Fluorescent Labeling of Foam Cell-Derived Extracellular Vesicles as Circulating Biomarkers for In Vitro Detection of Atherosclerosis

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(14), С. 10093 - 10102

Опубликована: Март 28, 2024

Real-time monitoring of the development atherosclerosis (AS) is key to management cardiovascular disease (CVD). However, existing laboratory approaches lack sensitivity and specificity, mostly due dearth reliable AS biomarkers. Herein, we developed an in vivo fluorescent labeling strategy that allows specific staining foam cell-derived extracellular vesicles (EVs) atherosclerotic plaques, which are released into blood as circulating biomarkers for vitro detection AS. This relies on a self-assembled nanoprobe could recognize cells specifically, where probe degraded by intracellular HClO produce trifluoromethyl-bearing boron-dipyrromethene fluorophore (termed B-CF3), lipophilic dye can be transferred exosomal membranes. These B-CF3-stained EVs detected directly fluorescence spectrometer or microplate reader without resorting any sophisticated analytical method. liquid-biopsy format enables early real-time differentiation lesion vulnerability during progression, facilitating effective CVD management.

Язык: Английский

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Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Theranostics, Год журнала: 2024, Номер 14(6), С. 2490 - 2525

Опубликована: Янв. 1, 2024

Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.

Язык: Английский

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Engineering Nanoplatforms for Theranostics of Atherosclerotic Plaques

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Апрель 2, 2024

Atherosclerotic plaque formation is considered the primary pathological mechanism underlying atherosclerotic cardiovascular diseases, leading to severe events such as stroke, acute coronary syndromes, and even sudden cardiac death. Early detection timely intervention of plaques are challenging due lack typical symptoms in initial stages. Therefore, precise early play a crucial role risk stratification achieving favorable post-interventional outcomes. The continuously advancing nanoplatforms have demonstrated numerous advantages including high signal-to-noise ratio, enhanced bioavailability, specific targeting capabilities for imaging agents therapeutic drugs, enabling effective visualization management plaques. Motivated by these superior properties, various noninvasive modalities recognition preliminary stage atherosclerosis comprehensively summarized. Additionally, several strategies proposed enhance efficacy treating Finally, existing challenges promising prospects accelerating clinical translation nanoplatform-based molecular therapy discussed. In conclusion, this review provides an insightful perspective on diagnosis

Язык: Английский

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Bridging biological and food monitoring: A colorimetric and fluorescent dual-mode sensor based on N-doped carbon dots for detection of pH and histamine

Journal of Hazardous Materials, Год журнала: 2024, Номер 470, С. 134271 - 134271

Опубликована: Апрель 10, 2024

Язык: Английский

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N-Cadherin Targeted Melanin Nanoparticles Reverse the Endothelial–Mesenchymal Transition in Vascular Endothelial Cells to Potentially Slow the Progression of Atherosclerosis and Cancer

ACS Nano, Год журнала: 2024, Номер 18(11), С. 8229 - 8247

Опубликована: Март 1, 2024

Endothelial–mesenchymal transition (EndoMT) of vascular endothelial cells has recently been considered as a key player in the early progression variety and nonvascular diseases, including atherosclerosis, cancer, organ fibrosis. However, current strategies attempting to identify pharmacological inhibitors block regulatory pathways EndoMT suffer from poor selectivity, unwanted side effects, heterogeneous response with different origins. Furthermore, focus on preventing EndoMT, leaving that have already undergone unresolved. Here, we report design simple but powerful nanoparticle system (i.e., N-cadherin targeted melanin nanoparticles) convert cytokine-activated, mesenchymal-like back their original phenotype. We term this process "Reversed EndoMT" (R-EndoMT). R-EndoMT allows impaired barriers recover quiescence intactness, significantly reduced leukocyte cancer cell adhesion transmigration, which could potentially stop atheromatous plaque formation metastasis stages. is achieved types originating arteries, veins, capillaries, independent activating cytokines. reveal nanoparticles reverse by downregulating an dependent RhoA activation pathway. Overall, approach offers prospect treat multiple EndoMT-associated diseases designing phenotypical cells.

Язык: Английский

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Fluorescent sensors for discriminative detection of multiple targets in pathological processes

Coordination Chemistry Reviews, Год журнала: 2023, Номер 489, С. 215203 - 215203

Опубликована: Май 9, 2023

Язык: Английский

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