Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells

Metabolites, Год журнала: 2023, Номер 13(7), С. 796 - 796

Опубликована: Июнь 27, 2023

Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are recognized hallmark of cancer and an important aspect treatment research. Abnormally elevated ROS often attributable to alterations in cellular metabolic activities increased oxidative stress, which affects both the development maintenance cancer. Moderately high beneficial maintain tumor cell genesis development, while toxic have been shown be force destroying cells. has become anticancer target based on proapoptotic effect ROS. Therefore, this review summarizes role DNA damage apoptosis cells caused by changes metabolism, as well various therapies targeting generation, order provide references generation.

Язык: Английский

---

Harnessing innate immune pathways for therapeutic advancement in cancer

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Март 25, 2024

Abstract The innate immune pathway is receiving increasing attention in cancer therapy. This ubiquitous across various cell types, not only cells but also adaptive cells, tumor and stromal cells. Agonists targeting the have shown profound changes microenvironment (TME) improved prognosis preclinical studies. However, to date, clinical success of drugs remains limited. Interestingly, recent studies that activation can paradoxically promote progression. uncertainty surrounding therapeutic effectiveness targeted for a critical issue needs immediate investigation. In this review, we observe role demonstrates heterogeneity, linked development stage, status, specific types. We propose within TME, exhibits multidimensional diversity. diversity fundamentally rooted cellular heterogeneity manifested as variety signaling networks. pro-tumor effect essentially reflects suppression classical pathways potential alternative pathways. Refining our understanding tumor’s network employing appropriate strategies enhance ability harness anti-tumor ultimately bridge gap from application.

Язык: Английский

---

Exploiting bacteria for cancer immunotherapy

Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(8), С. 569 - 589

Опубликована: Июнь 5, 2024

Язык: Английский

---

Cell–cell communication: new insights and clinical implications

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Авг. 7, 2024

Multicellular organisms are composed of diverse cell types that must coordinate their behaviors through communication. Cell-cell communication (CCC) is essential for growth, development, differentiation, tissue and organ formation, maintenance, physiological regulation. Cells communicate direct contact or at a distance using ligand-receptor interactions. So cellular encompasses two processes: signal conduction generation intercellular transmission signals, transduction reception procession signals. Deciphering networks critical understanding metabolism. First, we comprehensively review the historical milestones in CCC studies, followed by detailed description mechanisms molecule importance main signaling pathways they mediate maintaining biological functions. Then systematically introduce series human diseases caused abnormalities progress clinical applications. Finally, summarize various methods monitoring interactions, including imaging, proximity-based chemical labeling, mechanical force analysis, downstream analysis strategies, single-cell technologies. These aim to illustrate how functions depend on these interactions complexity regulatory regulate crucial processes, homeostasis, immune responses diseases. In addition, this enhances our processes occur after cell-cell binding, highlighting its application discovering new therapeutic targets biomarkers related precision medicine. This collective provides foundation developing targeted drugs personalized treatments.

Язык: Английский

---

Potential anti-tumor effects of regulatory T cells in the tumor microenvironment: a review

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Март 20, 2024

Abstract Regulatory T cells (Tregs) expressing the transcription factor FoxP3 are essential for maintaining immunological balance and a significant component of immunosuppressive tumor microenvironment (TME). Single-cell RNA sequencing (ScRNA-seq) technology has shown that Tregs exhibit plasticity functional diversity in various tumors within TME. This results playing dual role TME, which is not always centered around supporting progression as typically believed. Abundant data confirms anti-tumor activities their correlation with enhanced patient prognosis specific types malignancies. In this review, we summarize potential actions Tregs, including suppressing tumor-promoting inflammatory responses boosting immunity. addition, study outlines spatial temporal variations function to emphasize predictive significance malignancies may change. It comprehend effects improve therapy strategies.

Язык: Английский

---

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 23, 2024

Язык: Английский

---

Tumor microenvironment as a complex milieu driving cancer progression: a mini review

Clinical & Translational Oncology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 28, 2024

Язык: Английский

---

Probiotics functionalized with a gallium-polyphenol network modulate the intratumor microbiota and promote anti-tumor immune responses in pancreatic cancer

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 17, 2024

The intratumor microbiome imbalance in pancreatic cancer promotes a tolerogenic immune response and triggers immunotherapy resistance. Here we show that Lactobacillus rhamnosus GG probiotics, outfitted with gallium-polyphenol network (LGG@Ga-poly), bolster by modulating microbiota-immune interactions. Upon oral administration, LGG@Ga-poly targets tumors specifically, selectively eradicates tumor-promoting Proteobacteria microbiota-derived lipopolysaccharides through gallium-facilitated disruption of bacterial iron respiration. This elimination microbiota impedes the activation tumoral Toll-like receptors, thus reducing immunosuppressive PD-L1 interleukin-1β expression tumor cells, diminishing immunotolerant myeloid populations, improving infiltration cytotoxic T lymphocytes tumors. Moreover, hampers growth both preventive therapeutic contexts, amplifies antitumor efficacy checkpoint blockade preclinical models female mice. Overall, offer evidence thoughtfully designed biomaterials targeting can efficaciously augment for challenging cancer.

Язык: Английский

---

Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 21, 2024

Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt their environment by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth contributes treatment resistance. In primary breast metabolic shifts such as the Warburg effect enhanced lipid synthesis are closely linked chemotherapy failure. Similarly, metastatic lesions often display distinct profiles that not only sustain but also confer resistance targeted therapies immunotherapies. The review emphasizes two major aspects: mechanisms driving in both how unique environments sites further complicate treatment. By targeting vulnerabilities at stages, new strategies could improve efficacy existing provide better outcomes for cancer patients.

Язык: Английский

---

Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 8, 2025

Intratumor-resident bacteria represent an integral component of the tumor microenvironment (TME). Microbial dysbiosis, which refers to imbalance in bacterial composition and metabolic activities, plays important role regulating breast cancer development progression. However, impact specific intratumor-resident on progression their underlying mechanisms remain elusive. 16S rDNA gene sequencing was used analyze cancerous paracancerous tissues from patients. The mouse models bearing 4T1 cell tumors were employed assess influence colonization growth. Tissue infiltration regulatory T (Treg) cells CD8+ evaluated through immunohistochemistry flow cytometric analysis. Comparative metabolite profiling mice conducted using targeted metabolomics. Differential genes stimulated by analyzed transcriptomics validated qPCR assay. We found that Sphingobacterium displayed high abundance tissues. Intra-tumoral multivorum (S. multivorum) promoted tumor-bearing mice. Moreover, S. diminished therapeutic efficacy αPD-1 mAb, associated with increase infiltration, decrese infiltration. Targeted metabolomics revealed a conspicuous reduction propionylcarnitine colonized Furthermore, combination shown suppress growth compared alone vivo. Mechanistically, secretion chemokines CCL20 CXCL8 cells. secreted into TME facilitated recruitment Treg reduced thus promoting immune escape. This study reveals suppresses surveillance within TME, thereby

Язык: Английский

---