Life Sciences, Год журнала: 2024, Номер unknown, С. 123322 - 123322
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Cellular Physiology, Год журнала: 2024, Номер 239(4)
Опубликована: Янв. 29, 2024
Obesity and metabolic diseases, such as insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular ailments, represent formidable global health challenges, bearing considerable implications for both morbidity mortality rates. It has become increasingly evident that chronic, low-grade inflammation plays a pivotal role in the genesis advancement of these conditions. The involvement C-C chemokine ligand (CCL2) its corresponding receptor, receptor (CCR2), been extensively documented numerous inflammatory maladies. Recent evidence indicates CCL2/CCR2 pathway extends beyond immune cell recruitment inflammation, exerting notable influence on progression syndrome. present review seeks to furnish comprehensive exposition CCL2-CCR2 signaling axis within context obesity disorders, elucidating molecular mechanisms, functional roles, therapeutic implications.
Язык: Английский
Процитировано
11
Acta Pharmacologica Sinica, Год журнала: 2024, Номер unknown
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
6
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Spinal cord injury is characterized by high incidence and disability, the specific targets drugs have not yet been explored. Lipid droplet a type of organelles that regulates lipid metabolism oxidative stress. And regulatory mechanisms droplets on spinal remain unclear. Herein, it found GTPase activation Annexin A7 (ANXA7) promotes up-regulation genes related to formation. ANXA7 can interact with peroxisome proliferator-activated receptor gamma (PPARγ) enhance stability PPARγ, promote formation interaction mitochondria through promoting Perilipin 5 expression. Then, stress peroxidation are inhibited due promotion nuclear factor erythroid 2-related 2 (NRF2) translocation expression glutathione peroxidase 4 (GPX4). mitochondria-lipid enhancing which contributes inhibiting neuron damage. Furthermore, PPARγ neural function recovery repair in mice. The focus this study investigate effects regulated ANXA7/PPARγ, providing new strategies for injury.
Язык: Английский
Процитировано
0
Poultry Science, Год журнала: 2025, Номер 104(5), С. 105020 - 105020
Опубликована: Март 11, 2025
Avian pathogenic Escherichia coli (APEC) infection has high morbidity and mortality, multiple stressors encountered during rearing place poultry in a state of stress. However, research on how cope with APEC under stress situation is still limited. In this study, we established broiler model by corticosterone (CORT) administration subcutaneously for 7 consecutive days, followed challenge intramuscularly. CORT treatment significantly reduced body weight (BW) average daily gain (ADG) while increasing feed conversion ratio (FCR) (P < 0.01). decreased ADG elevated plasma heterophil to lymphocyte (H/L) 0.05). Additionally, aspartate aminotransferase (AST), AST alanine (AST/ALT) ratio, lactate dehydrogenase (LDH) levels increased Histopathological analysis revealed structural damage liver, indicating that induced liver injury. pretreatment broilers exhibited milder histopathological lesions lower AST, ALT, LDH 0.05) compared alone. lysozyme (LZM), total protein (TP), globulin (GLOB) 0.05), further elevating their concentrations alone, suggesting an enhanced innate immune response. Liver transcriptomic identified 768, 335, 567 differentially expressed genes (DEGs) following CORT, APEC, or both treatments, respectively, enriched cytokine-cytokine receptor interaction, PPAR signaling pathway, Toll-like MAPK steroid hormone biosynthesis arachidonic acid metabolism, phagosome etc., regulates lipid metabolism immunity, induces inflammation disrupts metabolism. Notably, may mitigate injury enhancing function. Moreover, glucocorticoid (GR) regulate DEGs expressions, thus affected response treatments. These results suggest treatment, infection, affect the growth performance, function broilers, play crucial role.
Язык: Английский
Процитировано
0
Journal of Medical Virology, Год журнала: 2025, Номер 97(4)
Опубликована: Апрель 1, 2025
ABSTRACT The membrane protein (M), a key structural of SARS‐CoV‐2 that regulates virus assembly and morphogenesis, is involved in the pathological processes multiple organ damage metabolic disorders. This study aims to elucidate mechanisms M‐mediated host ferroptosis lipid accumulation during infection. Here, we detected M enhances cellular sensitivity ferroptosis. Additionally, uncovered pivotal role perilipin‐2 sterol regulatory element‐binding 1 M‐induced accumulation. Xanthohumol, cost‐effective orally available diacylglycerol acyltransferase inhibitor, alleviated triglyceride total cholesterol accumulation, thereby counteracting Furthermore, identified mitochondrial import inner translocase subunit TIM23 receptor TOM20 homolog contribute dysfunction. Notably, inhibiting synthesis effectively reduced reactive oxygen species transmembrane potential, indicating cross‐talk between ferro pathways. Mechanistically, glutathione peroxidase 4 (GPX4) interacts with M, leading its subsequent degradation by Membrane Associated Ring‐CH‐Type Finger (MARCHF1) ubiquitin ligase. M‐GPX4 interaction occurs at R72 residue, which may represent potential therapeutic target against modulates further impairs functions, ultimately resulting through MARCHF1‐GPX4 axis. Disrupting host‐virus interactions along this pathway provide strategy for
Язык: Английский
Процитировано
0
Analytica Chimica Acta, Год журнала: 2024, Номер 1335, С. 343442 - 343442
Опубликована: Ноя. 20, 2024
Язык: Английский
Процитировано
0
Contact, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
The endoplasmic reticulum (ER) and lipid droplets (LDs) are essential organelles involved in synthesis, storage, transport. Physical membrane contacts between the ER LDs facilitate protein exchange thus play a critical role regulating cellular homeostasis. Recent research has revealed that ER-LD contact sites targeted by pathogens seeking to exploit host metabolic processes. Both viruses bacteria manipulate enhance their replication survival within host. This review discusses advancements elucidating mechanisms which through molecular mimicry cell manipulation, thereby hijacking processes pathogenesis. Understanding crosstalk during infection provides deeper insight into regulation uncovers potential therapeutic targets for treating infectious diseases.
Язык: Английский
Процитировано
0
Life Sciences, Год журнала: 2024, Номер unknown, С. 123322 - 123322
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0