Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 159079 - 159079
Опубликована: Дек. 1, 2024
Язык: Английский
Trends in Cognitive Sciences, Год журнала: 2024, Номер 28(7), С. 643 - 661
Опубликована: Фев. 22, 2024
Язык: Английский
Процитировано
37
Advanced Functional Materials, Год журнала: 2024, Номер 34(28)
Опубликована: Март 14, 2024
Abstract Achieving optimal implant restoration hinges on both robust osseointegration as the structural foundation and favorable osseoperception for advanced masticatory function. The significance of nerve innervation in peri‐implant environment cornerstone is often underestimated. Despite integral role endogenous electric fields (EFs) human body, particularly electrosensitive tissues like tissue, current approach involving external electrical stimulation invasive not clinically applicable. present study introduces a conductive hydrogel designed to respond EFs, aiming foster regeneration around dental implants coordinate osseoperception. promotes neurite outgrowth by upregulating intracellular Ca 2+ concentration activating subsequent pathways. Furthermore, enhanced release neuropeptides from neurocells improves osteogenesis osteoblasts. impact also thoroughly investigated vivo. This represents unique strategy enhancing within EFs environment. advancement opens door achieving physiological psychological integration implants.
Язык: Английский
Процитировано
23
Advanced Materials, Год журнала: 2024, Номер 36(15)
Опубликована: Янв. 31, 2024
Abstract Cellular energetics plays an important role in tissue regeneration, and the enhanced metabolic activity of delivered stem cells can accelerate repair regeneration. However, conventional hydrogels with limited network cell adaptability restrict cell–cell interactions activities. In this work, it is shown that a cell‐adaptable hydrogel high dynamics enhances glucose uptake fatty acid β ‐oxidation encapsulated human mesenchymal (hMSCs) compared low dynamics. It further hMSCs dynamic exhibit increased tricarboxylic (TCA) cycle activity, oxidative phosphorylation (OXPHOS), adenosine triphosphate (ATP) biosynthesis via E‐cadherin‐ AMP‐activated protein kinase (AMPK)‐dependent mechanism. The vivo evaluation showed delivery MSCs by situ bone regeneration animal model. believed findings provide critical insights into impact cell–biomaterial on cellular underlying mechanisms.
Язык: Английский
Процитировано
14
Bone Research, Год журнала: 2024, Номер 12(1)
Опубликована: Апрель 1, 2024
Abstract The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of organism. Among its various forms, skeletal specifically regulates bones. Osteoarthritis (OA) is a complex joint disorder involving cartilage, subchondral bone, synovium. bone undergoes continuous remodeling to adapt dynamic loads. Recent findings highlight that mediated aberrant mechanical loads contributes pathological resulting sclerosis OA. also potential mechanism for chronic synovial inflammation In this review, we offer general overview interoception, microenviroment remedeling. We discuss role abnormal OA, as well prospects challenges exploring novel OA therapies target interoception.
Язык: Английский
Процитировано
13
Small, Год журнала: 2024, Номер 20(23)
Опубликована: Янв. 10, 2024
Abstract Musculoskeletal (MSK) disorders significantly burden patients and society, resulting in high healthcare costs productivity loss. These are the leading cause of physical disability, their prevalence is expected to increase as sedentary lifestyles become common global population elderly increases. Proper innervation critical maintaining MSK function, nerve damage or dysfunction underlies various disorders, underscoring potential restoring function disorder treatment. However, most tissue engineering strategies have overlooked significance innervation. This review first expounds upon system its importance homeostasis functions. will be followed by for tissues that induce post‐implantation situ pre‐innervated. Subsequently, research progress modeling using innervated organoids organs‐on‐chips (OoCs) analyzed. Finally, future development treat recapitulate disease mechanisms discussed. provides valuable insights into underlying principles, methods, applications tissues, paving way targeted, efficacious therapies conditions.
Язык: Английский
Процитировано
7
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Апрель 16, 2024
Neuro bone tissue engineering is a multidisciplinary field that combines both principles of neurobiology and to develop innovative strategies for repairing regenerating injured tissues. Despite the fact regeneration development are considered two distinct biological processes, yet can be reactivation in later life stages restore missing It noteworthy capabilities vary from one organism another (teleost fishes, hydra, humans), or even same dependent on itself (Human central nervous system vs. peripheral system). The skeletal highly innervated, plays role conveying signals connecting with organs, moreover it has been shown they play an important regeneration. Their conveyed by different cells' resident its endoneurium (fibroblasts, microphages, vasculature associated cells, Schwann cells) these cells secrete various growth factors (NGF, BDNF, GDNF, NT-3, bFGF) contribute regenerative phenotype. synchronize together regulating homeostasis through neurogenic neural circuits. Receptors peptides such as Serotonin, Leptin, Semaphorins, BDNF expressed playing homeostasis, metabolism This review will highlight crosstalk between nerves developmental well neuro-bone severe injuries.
Язык: Английский
Процитировано
4
International Immunopharmacology, Год журнала: 2025, Номер 149, С. 114213 - 114213
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
0
Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102743 - 102743
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Pain, Год журнала: 2025, Номер unknown
Опубликована: Май 21, 2025
Abstract Pain is one of the primary indicators a bone fracture and serves both functional practical role in guiding recovery. However, pain can persist long after itself has clinically healed. The neural molecular mechanisms that drive acute postfracture, how these are pathologically usurped to trap patients into persistent, debilitating, often difficult treat, chronic pain, not well understood. aim this review provide insight risk factors for persistence fracture, physiological pathophysiological critically evaluate literature around assessment techniques/models. Taken together, concepts covered herein will strong foundation support development more effective treatments better alleviate postfracture pain.
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 389 - 431
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0