Effect of physical activity on long COVID fatigue: an unsolved enigma DOI Creative Commons

Francesco Coscia,

Ester Sara Di Filippo,

Paola Virginia Gigliotti

и другие.

European Journal of Translational Myology, Год журнала: 2023, Номер 33(3)

Опубликована: Сен. 4, 2023

Covid-19 disease is well documented and often the most common symptoms include myalgia muscle fatigue. Approximately 10% of those infected complain persistent fatigue even many months after end acute phase disease. This gives rise to a condition different from previous one commonly known as 'post-acute COVID-19 syndrome' or simply Long-COVID. Although origin multifactorial, state prolonged observed in Long-COVID syndrome suggests existence possible atrophy rather sarcopenia. Under these conditions, use physical activity programs can effectively counteract underlying phenomena observed. If this also situation during Long-COVID, muscular symptom should be positively influenced by administration programmed cycles. In fact, patients with few published papers seem indicate that who are physically active make an effort engage illness have decreased duration intensity illness. However, analysis studies literature small percentage people do not appear benefit application programs, so further on homogeneous samples needed provide firm answer question: planned help pathological course Long-COVID?

Язык: Английский

Immune response in COVID-19: what is next? DOI Creative Commons
Qing Li, Ying Wang, Qiang Sun

и другие.

Cell Death and Differentiation, Год журнала: 2022, Номер 29(6), С. 1107 - 1122

Опубликована: Май 17, 2022

Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more than 2 years and it still impacts our daily lifestyle quality in unprecedented ways. A better understanding of immunity its regulation response to SARS-CoV-2 infection is urgently needed. Based on the current literature, we review here various virus mutations evolving manifestations along with alterations immune responses specific focuses innate response, neutrophil extracellular traps, humoral immunity, cellular immunity. Different types vaccines were compared analyzed based their unique properties elicit Various therapeutic strategies such as antibody, anti-viral medications inflammation control discussed. We predict that available continuously emerging new technologies, powerful administration schedules, effective public health measures, COVID-19 will be under near future.

Язык: Английский

Процитировано

114
A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries DOI Open Access
Daren K. Heyland, Lucy Wibbenmeyer, Jonathan R. Pollack

и другие.

New England Journal of Medicine, Год журнала: 2022, Номер 387(11), С. 1001 - 1010

Опубликована: Сен. 9, 2022

Glutamine is thought to have beneficial effects on the metabolic and stress response severe injury. Clinical trials involving patients with burns other critically ill shown conflicting results regarding benefits risks of glutamine supplementation.

Язык: Английский

Процитировано

61
Understanding Long COVID; Mitochondrial Health and Adaptation—Old Pathways, New Problems DOI Creative Commons
Alistair V.W. Nunn,

Geoffrey W. Guy,

Wolfgang Brysch

и другие.

Biomedicines, Год журнала: 2022, Номер 10(12), С. 3113 - 3113

Опубликована: Дек. 2, 2022

Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as "brain fog", fatigue and clotting problems. Explanations for "long COVID" include immune imbalance, incomplete viral clearance potentially, mitochondrial dysfunction. As conditions sub-optimal function are associated initial severity of disease, their prior health could be key in resistance to long COVID recovery. The SARs virus redirects host metabolism towards replication; response, can metabolically react control virus. Resolution is normally achieved after stress activates a hormetic negative feedback mechanism. It therefore possible that, some individuals function, "tip" into chronic inflammatory cycle. This might explain main including platelet Long thus described virally induced self-perpetuating imbalanced non-resolving state characterised by dysfunction, where reactive oxygen species continually drive inflammation shift glycolysis. would suggest that sufferer's needs "tipped" back using stimulus, physical activity, calorie restriction, or chemical compounds mimic these enhancing perhaps combination inhibitors quell response.

Язык: Английский

Процитировано

54
Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID DOI Creative Commons
Kaiming Wang,

Mobin Khoramjoo,

Karthik K. Srinivasan

и другие.

Cell Reports Medicine, Год журнала: 2023, Номер 4(11), С. 101254 - 101254

Опубликована: Окт. 26, 2023

The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adverse multisystem consequences. We obtain plasma samples from 117 individuals during 6 months following their acute phase infection to comprehensively profile assess changes in cytokines, proteome, metabolome. Network analysis reveals sustained inflammatory response, platelet degranulation, cellular activation convalescence accompanied by dysregulation arginine biosynthesis, methionine metabolism, taurine tricarboxylic acid (TCA) cycle processes. Furthermore, we develop a prognostic model composed 20 molecules involved regulating T cell exhaustion energy metabolism that can reliably predict clinical outcomes discharge 83% accuracy an area under the curve (AUC) 0.96. Our study pertinent biological processes differ infection, it supports development specific therapies biomarkers for patients suffering COVID.

Язык: Английский

Процитировано

27
Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID DOI Creative Commons
A. Satyanarayan Naidu, Chin‐Kun Wang, Pingfan Rao

и другие.

npj Science of Food, Год журнала: 2024, Номер 8(1)

Опубликована: Март 30, 2024

Язык: Английский

Процитировано

8
COVID‐19 metabolism: Mechanisms and therapeutic targets DOI
Tianshi Wang, Ying Cao, Haiyan Zhang

и другие.

MedComm, Год журнала: 2022, Номер 3(3)

Опубликована: Авг. 9, 2022

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) dysregulates antiviral signaling, immune response, and cell metabolism in human body. Viral genome proteins hijack host metabolic network to support viral biogenesis propagation. However, the regulatory mechanism of SARS‐CoV‐2‐induced dysfunction has not been elucidated until recently. Multiomic studies disease 2019 (COVID‐19) revealed an intensive interaction between regulators proteins. SARS‐CoV‐2 deregulated cellular blood, intestine, liver, pancreas, fat, cells. Host supported almost every stage lifecycle. Strikingly, were found interact with enzymes different compartments. Biochemical genetic assays also identified key nodes dependencies replication. Of note, cholesterol metabolism, lipid glucose are broadly involved Here, we summarized current understanding hallmarks COVID‐19 metabolism. infection remodels which turn modulates Remodeling creates vulnerability replication, could be explored uncover new therapeutic targets. The efficacy inhibitors against is under investigation several clinical trials. Ultimately, knowledge reprogramming would accelerate drug repurposing or screening combat pandemic.

Язык: Английский

Процитировано

34
Glutamine metabolism and optimal immune and CNS function DOI Creative Commons
Philip Newsholme, Vinícius Leonardo Sousa Diniz, Garron T. Dodd

и другие.

Proceedings of The Nutrition Society, Год журнала: 2022, Номер 82(1), С. 22 - 31

Опубликована: Окт. 26, 2022

Nutrients can impact and regulate cellular metabolism cell function which is particularly important for the activation of diverse immune subsets. Among critical nutrients fate, glutamine possibly most widely recognised immunonutrient, playing key roles in TCA cycle, heat shock protein responses antioxidant systems. In addition, also involved with inter-organ ammonia transport, this not only cells, but to brain, especially catabolic situations such as care extenuating exercise. The well characterised fall blood availability has been main reason studies investigate possible effects replacement via supplementation many results are poor agreement. At same time, a range complex pathways have revealed studies. This article will briefly review system, emphasis on metabolic mechanisms, emerging role brain glutamate/gamma-amino butyric acid cycle. relevant aspects discussed.

Язык: Английский

Процитировано

29
Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection DOI Open Access

Henry W. Barnes,

Sally Demirdjian, Naomi L. Haddock

и другие.

Matrix Biology, Год журнала: 2023, Номер 116, С. 49 - 66

Опубликована: Фев. 1, 2023

Язык: Английский

Процитировано

17
NAD+ metabolism-based immunoregulation and therapeutic potential DOI Creative Commons
Jiankai Fang,

Wangwang Chen,

Pengbo Hou

и другие.

Cell & Bioscience, Год журнала: 2023, Номер 13(1)

Опубликована: Май 10, 2023

Abstract Nicotinamide adenine dinucleotide (NAD + ) is a critical metabolite that acts as cofactor in energy metabolism, and serves cosubstrate for non-redox NAD -dependent enzymes, including sirtuins, CD38 poly(ADP-ribose) polymerases. metabolism can regulate functionality attributes of innate adaptive immune cells contribute to inflammatory responses. Thus, the manipulation bioavailability reshape courses immunological diseases. Here, we review basics biochemistry its roles response, discuss current challenges future translational potential research development therapeutics diseases, such COVID-19.

Язык: Английский

Процитировано

17
Long-COVID, Metabolic and Endocrine Disease DOI Creative Commons
Stefan R. Bornstein, Dragoş Cozma,

Margrit Kamel

и другие.

Hormone and Metabolic Research, Год журнала: 2022, Номер 54(08), С. 562 - 566

Опубликована: Июнь 20, 2022

In the aftermath of corona pandemic, long-COVID or post-acute COVID-19 syndrome still represents a great challenge, and this topic will continue to represent significant health problem in coming years. At present, impact on our system cannot be fully assessed but according current studies, up 40% people who have been infected with SARS-CoV-2 suffer from clinically relevant symptoms several weeks months after acute phase. The main are chronic fatigue, dyspnea, various cognitive symptoms. Initial studies shown that overweight diabetes mellitus higher risk developing associated Furthermore, repeated treatment steroids can contribute long-term metabolic endocrine disorders. Therefore, structured program rehabilitation physical activity as well optimal dietary management is utmost importance, especially for patients diseases and/or long-COVID. removal autoantibodies specific therapeutic apheresis procedures could lead improvement individual patients.

Язык: Английский

Процитировано

27