Basic implications on three pathways associated with SARS-CoV-2
Biomedical Journal,
Год журнала:
2024,
Номер
unknown, С. 100766 - 100766
Опубликована: Июль 1, 2024
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
interacts
between
the
host
and
virus
govern
induction,
resulting
in
multiorgan
impacts.
Its
pathophysiology
involves
followings:
1)
angiotensin-converting
enzyme
(ACE2)
Toll-like
receptor
(TLR)
pathways:
2)
neuropilin
(NRP)
pathway:
3)
spike
protein
pathway.
Therefore,
it
is
necessary
to
block
pathological
course
with
modulating
innate
lymphoid
cells
against
diverse
corona
variants
future.
Язык: Английский
Pre-Infection Nutritional Status, Oxidative Stress, and One-Year-Long COVID Persistence in Patients Undergoing Hemodialysis: A Prospective Cohort Study
Clinics and Practice,
Год журнала:
2024,
Номер
14(3), С. 892 - 905
Опубликована: Май 17, 2024
Background:
Nutritional
status’s
role
in
long
COVID
is
evident
the
general
population,
yet
unexplored
patients
undergoing
hemodialysis
(HD),
posing
a
research
gap.
We
hypothesized
that
pre-infection
undernutrition
HD
might
impact
persistence
by
accelerating
oxidative
stress.
The
present
study
aimed
to
investigate
association
between
nutritional
status,
stress,
and
one-year-long
patients.
Methods:
This
prospective
observational
cohort
enrolled
115
with
confirmed
COVID-19.
status
was
assessed
using
Controlling
Status
(CONUT)
score
twice:
before
infection
three
months
post-infection.
Oxidative
markers
included
malondialdehyde
(MDAs),
ceruloplasmin,
transferrin,
sulfhydryl
groups.
endpoint
persistence.
Results:
Moderate
CONUT
scores
were
associated
heightened
severe
risk
(p
<
0.0001),
elevated
MDAs
reduced
ceruloplasmin
levels
=
0.0009)
at
post-COVID-19
compared
light
scores.
Pre-infection
independently
predicted
post-COVID
damage
[OR
2.3
(95%
CI
1.2;
4.6),
p
0.0001]
[HR
4.6
1.4;
9.9),
0.0001],
even
after
adjusting
for
potential
confounders.
Conclusion:
heightens
stress
increases
of
Язык: Английский
Precision nutrition-based strategy for management of human diseases and healthy aging: current progress and challenges forward
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Авг. 9, 2024
Currently,
the
treatment
of
various
human
ailments
is
based
on
different
therapeutic
approaches
including
traditional
and
modern
medicine
systems.
Precision
nutrition
has
come
into
existence
as
an
emerging
approach
considering
diverse
aspects
such
age,
sex,
genetic
epigenetic
makeup,
apart
from
pathophysiological
conditions.
The
continuously
gradually
evolving
disciplines
genomics
about
have
elucidated
importance
variations,
information,
expression
myriads
genes
in
disease
progression
involvement
modulating
responses.
Further,
investigations
presented
considerable
role
gut
microbiota
comprising
commensal
symbionts
performing
innumerable
activities
release
bioactive
molecules,
defense
against
pathogenic
microbes,
regulation
immunity.
Noteworthy,
characteristics
microbiome
change
depending
host
attributes,
environmental
factors,
habitat,
addition
to
diet,
therefore
can
be
employed
a
biomarker
unravel
response
given
food.
specific
diet
components
thereof
suggested
for
supporting
enrichment
desired
microbial
community
some
extent
important
part
precision
achieve
not
only
goal
health
but
also
healthy
aging.
Язык: Английский
Mechanistic Insights into Targeting SARS-CoV-2 Papain-like Protease in the Evolution and Management of COVID-19
BioChem,
Год журнала:
2024,
Номер
4(3), С. 268 - 299
Опубликована: Сен. 23, 2024
The
COVID-19
pandemic,
instigated
by
the
emergence
of
novel
coronavirus,
SARS-CoV-2,
created
an
incomparable
global
health
crisis.
Due
to
its
highly
virulent
nature,
identifying
potential
therapeutic
agents
against
this
lethal
virus
is
crucial.
PLpro
a
key
protein
involved
in
viral
polyprotein
processing
and
immune
system
evasion,
making
it
prime
target
for
development
antiviral
drugs
combat
COVID-19.
To
expedite
search
candidates,
review
delved
into
computational
studies.
Recent
investigations
have
harnessed
methods
identify
promising
inhibitors
targeting
PLpro,
aiming
suppress
activity.
Molecular
docking
techniques
were
employed
researchers
explore
binding
sites
within
catalytic
region
PLpro.
elucidates
functional
structural
properties
SARS-CoV-2
underscoring
significance
pathogenicity
replication.
Through
comprehensive
all-atom
molecular
dynamics
(MD)
simulations,
stability
drug–PLpro
complexes
was
assessed,
providing
dynamic
insights
their
interactions.
By
evaluating
energy
estimates
from
MD
stable
with
identified.
This
offers
overview
drug/lead
candidates
discovered
thus
far
using
diverse
silico
methodologies,
encompassing
drug
repurposing,
structure-based,
ligand-based
virtual
screenings.
Additionally,
identified
are
listed
based
on
chemical
structures
meticulously
examined
according
various
parameters,
such
as
estimated
free
(ΔG),
types
intermolecular
interactions,
PLpro–ligand
complexes,
determined
outcomes
simulations.
Underscoring
pivotal
role
battle
COVID-19,
establishes
robust
foundation
integrating
modeling,
insights.
continual
imperative
improvement
existing
exploring
compounds
remains
paramount
efforts
evolution
management
hinge
symbiotic
relationship
between
experimental
validation,
interdisciplinary
synergy
crucial
endeavor.
Язык: Английский
Pre-infection Nutritional Status, Oxidative Stress, and One-Year Long COVID Persistence in Patients Undergoing Hemodialysis: A Prospective Cohort Study
Опубликована: Апрель 16, 2024
Background:
Nutritional
status
and
oxidative
stress
have
been
implicated
in
the
pathogenesis
persistence
of
long
COVID,
but
data
patients
undergoing
hemodialysis
(HD)
are
limited.
The
present
study
aimed
to
investigate
association
between
pre-infection
nutritional
status,
stress,
one-year
COVID
HD
patients.
Methods:
This
prospective
observational
cohort
enrolled
115
with
confirmed
COVID-19.
was
assessed
using
Controlling
Status
(CONUT)
score
twice:
before
infection
three
months
post-infection.
Oxidative
markers
included
malondialdehyde
(MDAs),
ceruloplasmin,
transferrin,
sulfhydryl
groups.
endpoint
persistence.
Results:
Moderate
CONUT
scores
were
associated
heightened
severe
undernutrition
risk
(p
&lt;
0.0001),
elevated
MDAs
reduced
ceruloplasmin
levels
=
0.0009)
at
post-COVID-19
compared
light
scores.
Pre-infection
independently
predicted
post-COVID
damage
[OR
2.3
(95%CI
1.2;
4.6),
p
0.0001]
[HR
4.6
1.4;
9.9),
0.0001],
even
after
adjusting
for
potential
confounders.
Conclusion:
increased
intensity
Язык: Английский
The Possible Impact of COVID-19 on Glycated Hemoglobin and Systolic Blood Pressure in Type 2 Diabetes and Obesity
Obesities,
Год журнала:
2024,
Номер
4(4), С. 412 - 426
Опубликована: Окт. 25, 2024
Background:
There
are
still
discrepancies
in
the
literature
as
to
whether
COVID-19
infection
could
impact
biochemical,
anthropometric,
and
cardiovascular
markers.
The
purpose
of
this
study
was
firstly
observe
effects
over
12
months
on
Type
2
diabetes
(T2D)
obesity.
Secondarily,
we
analyzed
individual
influence
changes
Methods:
This
is
part
a
secondary
analysis
recently
published
article.
research
involved
84
participants
with
T2D,
divided
into
two
groups:
control
group
(40
participants)
received
only
medical
care,
while
intervention
(44
both
care
nutritional
assessment.
Consultations
were
held
quarterly
months,
follow-up
after
3
months.
Data
Analysis:
For
analysis,
non-normal
variables
compared
using
Mann–Whitney
test,
normal
unpaired
t-tests.
all
cases,
α
=
0.05
p
<
considered
significant.
Results:
revealed
high
percentage
patients
groups
who
had
(70%
72.7%
intervention)
Regarding
infected
showed
smaller
reductions
glycated
hemoglobin
(HbA1c)
(p
0.0120)
systolic
blood
pressure
(SBP)
0.0460).
other
markers,
groups,
no
significant
differences
found
>
0.05).
Conclusion:
possibly
influenced
SBP
HbA1c
levels
people
T2D
However,
caution
should
be
exercised
generalizing
these
results
due
limitations
study.
Additionally,
does
not
establish
causal
relationship,
more
clinical
trials
different
populations
needed
fully
analyze
topic.
Язык: Английский
Vitamin D Deficiency And Risk Of COVID-19 Infection
INTERNATIONAL JOURNAL OF HEALTH & MEDICAL RESEARCH,
Год журнала:
2024,
Номер
03(05)
Опубликована: Май 15, 2024
There
is
an
urgent
need
for
new
supportive
treatment
options
against
infectious
viral
diseases,
given
the
rapid
spread
and
huge
number
of
individuals
affected
worldwide
by
these
so
cost-effective,
globally
available
safe
with
minimal
side
effects
simple
application
are
highly
assured.
This
study
will
therefore
discuss
potential
vitamin
D
supplementation
as
a
preventive
therapeutic
agent
in
combination
other
strategies,
this
meets
all
criteria
described
above.
A
variety
data
on
association
respiratory
infections
infections,
well
immune
response
vitamin.Vitamin
deficiency
adds
to
variables
that
make
people
more
susceptible
infection
damaging
development
COVID-19,
there
correlation
between
its
levels
body
severity
COVID-19
infections.
Due
direct
antiviral
anti-inflammatory
properties,
it
can
be
assumed
maintaining
within
normal
necessary
maintain
health
body,
when
level
below
optimal
level,
compensated
supplements.
Язык: Английский
SARS-CoV-2 and Environmental Changes: The Perfect Storm
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(11), С. 11835 - 11852
Опубликована: Окт. 23, 2024
The
COVID-19
pandemic
has
had
a
significant
impact
on
the
global
economy.
It
also
provided
insights
into
how
looming
climate
crisis
might
be
addressed,
as
there
are
several
similarities
between
challenges
proposed
by
and
those
expected
from
coming
emergency.
is
an
immediate
health
threat,
but
change
represents
more
gradual
insidious
risk
that
will
lead
to
long-term
consequences
for
human
health.
Research
shows
change,
air
pollution
pandemics
have
negative
Recent
studies
show
mortality
increases
with
extremes.
goal
of
our
review
analyze
clinical
findings
they
affected
while
providing
insight
emergence
new
variants
their
ability
evade
immune
system.
We
selected
synthesized
data
primary
studies,
reviews,
meta-analyses,
systematic
reviews.
Selection
was
based
rigorous
methodological
relevance
criteria.
Indeed,
variant
SARS-CoV-2,
named
JN.1,
emerged
dominant,
first
in
United
States
then
worldwide;
specific
mutations
its
spike
proteins
increase
transmissibility.
According
World
Health
Organization
(WHO),
JN.1
currently
most
reported
interest
(VOI),
having
been
identified
132
countries.
highlight
link
pandemics,
emphasizing
need
action,
targeted
medical
approaches
scientific
innovation.
Язык: Английский