Frontiers in Molecular Biosciences,
Год журнала:
2025,
Номер
12
Опубликована: Март 19, 2025
In
skeletal
muscle,
calcium
is
not
only
essential
to
stimulate
and
sustain
their
contractions
but
also
for
muscle
embryogenesis,
regeneration,
energy
production
in
mitochondria,
fusion.
Different
ion
channels
contribute
achieving
the
various
functions
of
muscles.
Muscle
contraction
initiated
by
releasing
from
sarcoplasmic
reticulum
through
ryanodine
receptor
gated
mechanically
four
dihydropyridine
receptors
T-tubules.
The
influx
store-operated
sustains
stimulates
regeneration.
Mitochondrial
uniporter
allows
entry
into
mitochondria
oxidative
phosphorylation.
Aging
alters
expression
activity
these
different
channels,
resulting
a
reduction
force
generation
regeneration
capacity.
Regular
physical
training
bioactive
molecules
nutrients
can
prevent
effects
aging
on
channels.
This
review
focuses
current
knowledge
muscles’
Frontiers in Cell and Developmental Biology,
Год журнала:
2022,
Номер
10
Опубликована: Авг. 30, 2022
With
aging,
the
progressive
loss
of
skeletal
muscle
will
have
negative
effect
on
multiple
physiological
parameters,
such
as
exercise,
respiration,
thermoregulation,
and
metabolic
homeostasis.
Accumulating
evidence
reveals
that
oxidative
stress
inflammation
are
main
pathological
characteristics
during
aging.
Here,
we
focus
aging-related
sarcopenia,
summarize
relationship
between
aging
elaborate
aging-mediated
damage
in
its
critical
role
occurrence
development
sarcopenia.
In
addition,
discuss
production
excessive
reactive
oxygen
species
muscle,
which
reduces
ability
satellite
cells
to
participate
regeneration,
analyze
potential
molecular
mechanism
ROS-mediated
mitochondrial
dysfunction
muscle.
Furthermore,
also
paid
extensive
attention
possibility
regulatory
pathways
mediate
inflammation.
Finally,
response
abnormal
activity
several
antioxidant
anti-inflammatory
strategies
for
treatment
may
provide
beneficial
help
improving
sarcopenia
Cells,
Год журнала:
2023,
Номер
12(17), С. 2183 - 2183
Опубликована: Авг. 30, 2023
Mitochondria
are
the
primary
source
of
energy
production
and
implicated
in
a
wide
range
biological
processes
most
eukaryotic
cells.
Skeletal
muscle
heavily
relies
on
mitochondria
for
supplements.
In
addition
to
being
powerhouse,
evoke
many
functions
skeletal
muscle,
including
regulating
calcium
reactive
oxygen
species
levels.
A
healthy
population
is
necessary
preservation
homeostasis,
while
dysregulation
linked
numerous
myopathies.
this
review,
we
summarize
recent
studies
function
quality
control
focusing
mainly
vivo
rodents
human
subjects.
With
an
emphasis
interplay
between
mitochondrial
concerning
fiber
type-specific
phenotypes,
also
discuss
effect
aging
exercise
remodeling
properties.
Redox Biology,
Год журнала:
2023,
Номер
62, С. 102693 - 102693
Опубликована: Апрель 1, 2023
Vascular
aging
contributes
to
adverse
changes
in
organ
function
and
is
a
significant
indicator
of
major
cardiac
events.
Endothelial
cells
(ECs)
participate
aging-provoked
coronary
vascular
pathology.
Regular
exercise
associated
with
preservation
arterial
humans.
However,
the
molecular
basis
not
well
understood.
The
present
study
was
aimed
determine
effects
on
endothelial
senescence
whether
mitochondrial
clearance
regulator
FUN14
domain
containing
1
(FUNDC1)-related
mitophagy
homeostasis
were
involved.
In
mouse
arteries,
FUNDC1
levels
showed
gradually
decrease
age.
Both
microvascular
(CMECs)
significantly
reduced
aged
mice
rescued
by
training.
Exercise
also
alleviated
CMECs
as
evidenced
β-galactosidase
activity
markers,
prevented
abnormal
cell
migration,
proliferation,
eNOS
activation
from
mice,
improved
endothelium-dependent
vasodilation
artery,
myocardial
neutrophil
infiltration
inflammatory
cytokines
evoked
MI/R,
restored
angiogenesis
consequently
MI/R
injury
aging.
Importantly,
deletion
abolished
protective
roles
overexpression
ECs
adeno-associated
virus
(AAV)
reversed
injury.
Mechanistically,
PPARγ
played
an
important
role
regulating
expressions
endothelium
under
exercise-induced
laminar
shear
stress.
conclusion,
prevents
arteries
via
increasing
PPARγ-dependent
manner,
subsequently
protects
against
These
findings
highlight
FUNDC1-mediated
potential
therapeutic
target
that
vulnerability.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Авг. 21, 2023
Cardiovascular
ageing
is
a
process
that
begins
early
in
life
and
leads
to
progressive
change
structure
decline
function
due
accumulated
damage
across
diverse
cell
types,
tissues
organs
contributing
multi-morbidity.
Damaging
biophysical,
metabolic
immunological
factors
exceed
endogenous
repair
mechanisms
resulting
pro-fibrotic
state,
cellular
senescence
end-organ
damage,
however
the
genetic
architecture
of
cardiovascular
not
known.
Here
we
use
machine
learning
approaches
quantify
age
from
image-derived
traits
vascular
function,
cardiac
motion
myocardial
fibrosis,
as
well
conduction
electrocardiograms,
39,559
participants
UK
Biobank.
found
be
significantly
associated
with
common
or
rare
variants
genes
regulating
sarcomere
homeostasis,
immunomodulation,
tissue
responses
biophysical
stress.
Ageing
accelerated
by
cardiometabolic
risk
also
identify
prescribed
medications
are
potential
modifiers
ageing.
Through
large-scale
modelling
multiple
our
results
reveal
insights
into
driving
premature
molecular
targets
attenuate
age-related
processes.
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 1, 2024
Globally,
the
onset
and
progression
of
multiple
human
diseases
are
associated
with
mitochondrial
dysfunction
dysregulation
Ca2+
uptake
dynamics
mediated
by
calcium
uniporter
(MCU)
complex,
which
plays
a
key
role
in
dysfunction.
Despite
relevant
studies,
underlying
pathophysiological
mechanisms
have
not
yet
been
fully
elucidated.
This
article
provides
an
in-depth
analysis
current
research
status
MCU
focusing
on
its
molecular
composition,
regulatory
mechanisms,
association
diseases.
In
addition,
we
conducted
effects
agonists,
inhibitors,
traditional
Chinese
medicine
(TCM)
monomers
complex
their
application
prospects
disease
treatment.
From
perspective
medicinal
chemistry,
structure–activity
relationship
between
these
small
molecules
deduced
potential
pharmacophores
binding
pockets.
Simultaneously,
structural
domains
Homo
sapiens
were
identified.
We
also
studied
functional
expression
Drosophila,
Zebrafish,
Caenorhabditis
elegans.
These
analyses
provide
basis
for
exploring
treatment
strategies
targeting
strong
support
development
future
precision
treatments.
The
exhibits
varying
behavior
across
different
tissues
various
roles
metabolic
functions.
It
consists
six
subunits,
essential
regulator
(EMRE),
solute
carrier
25A23
(SLC25A23).
They
regulate
processes,
such
as
(mCa2+)
uptake,
adenosine
triphosphate
(ATP)
production,
dynamics,
oxidative
stress
(OS),
cell
death.
Regulation
makes
it
target
treating
diseases,
especially
cardiovascular
neurodegenerative
inflammatory
tumors.
The
Taihe
black-boned
silky
fowl,
a
distinguished
indigenous
breed
of
chicken,
is
renowned
for
its
dual
utility
in
both
traditional
medicinal
and
culinary
applications.
However,
the
faces
significant
challenges
due
to
suboptimal
reproductive
capabilities
notably
brief
egg-laying
period,
which
have
impeded
broader
development
cultivation.
In
this
research
endeavor,
we
employed
an
advanced,
rapid
DIA
(Data
independent
acquisition)
quantitative
proteomics
method
on
Astral
platform
meticulously
analyze
ovarian
proteome
these
chickens.
By
analyzing
proteomic
information
fowl
during
peak
decline
periods,
aim
identify
potential
candidate
proteins
molecular
mechanisms
underlying
decline.
This
could
enable
us
implement
interventions
improve
efficiency
valuable
breed.
study,
total
8,281
were
identified
within
fowl.
Among
these,
303
exhibited
differential
expression,
with
98
significantly
up-regulated
205
down-regulated.
functional
annotation
illuminated
their
crucial
roles
steroid
hormone
synthesis
pathways,
are
pivotal
egg
production.
Furthermore,
later
stages
laying,
there
was
noticeable
upregulation
associated
inflammatory
senescence
oxidative
stress.
change
suggests
increase
stress
ovary,
highlighting
physiological
shifts
that
affect
productivity
as
chickens
age.
study
key
protein
markers
critical
phases
cycle,
specifically
late
periods.
These
findings
contribute
new
scientific
insights
can
be
utilized
breeding
optimization
effective
management
unique
elucidating
dynamics
different
laying
phases,
offers
strategies
aimed
at
enhancing
performance
extending
lifespan
lead
improvements
sustainability
profitability
farming
Endocrine Reviews,
Год журнала:
2023,
Номер
44(4), С. 668 - 692
Опубликована: Фев. 2, 2023
Abstract
Mitochondria
sense
both
biochemical
and
energetic
input
in
addition
to
communicating
signals
regarding
the
state
of
cell.
Increasingly,
these
signaling
organelles
are
recognized
as
key
for
regulating
different
cell
functions.
This
review
summarizes
recent
advances
mitochondrial
communication
striated
muscle,
with
specific
focus
on
processes
by
which
mitochondria
communicate
each
other,
other
organelles,
across
distant
organ
systems.
Intermitochondrial
muscle
is
mediated
via
conduction
membrane
potential
adjacent
mitochondria,
physical
interactions,
fusion
or
fission,
nanotunnels,
allowing
exchange
proteins,
DNA,
nucleotides,
peptides.
Within
cells,
mitochondria-organelle
can
modulate
overall
function.
The
various
mechanisms
fitness
rest
body
suggest
that
extracellular
during
health
disease.
Whereas
mitochondria-derived
vesicles
might
excrete
endocrine
compounds,
stimulation
stress
lead
release
fibroblast
growth
factor
21
(FGF21)
differentiation
15
(GDF15)
into
circulation
whole-body
physiology.
Circulating
DNA
well-known
alarmins
trigger
immune
system
may
help
explain
low-grade
inflammation
chronic
diseases.
Impaired
function
central
common
heart
skeletal
pathologies,
including
cardiomyopathies,
insulin
resistance,
sarcopenia.
Lastly,
important
new
research
endocrinology,
communication,
medical
horizons,
translational
aspects
discussed.
