The journal of nutrition health & aging, Год журнала: 2024, Номер 28(11), С. 100368 - 100368
Опубликована: Сен. 21, 2024
Язык: Английский
Biochemical Pharmacology, Год журнала: 2023, Номер 214, С. 115664 - 115664
Опубликована: Июнь 16, 2023
Язык: Английский
Процитировано
104
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Март 14, 2023
Abstract The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition deteriorated disorders. Rejuvenation refers giving aged cells or organisms youthful characteristics through various techniques, such as reprogramming and epigenetic regulation. great leaps in rejuvenation prove that not one-way street, many rejuvenative interventions have emerged delay even reverse the process. Defining mechanism by which roadblocks signaling inputs influence complex programs essential for understanding developing strategies. Here, we discuss intrinsic extrinsic factors counteract cell rejuvenation, targeted core mechanisms involved this Then, critically summarize latest advances state-of-art strategies of rejuvenation. Various methods also provide insights treating specific ageing-related diseases, including reprogramming, removal senescence (SCs) suppression senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune heterochronic transplantation, etc. potential applications therapy extend cancer treatment. Finally, analyze detail therapeutic opportunities challenges technology. Deciphering will further into anti-ageing disease treatment clinical settings.
Язык: Английский
Процитировано
85
Nature Reviews Endocrinology, Год журнала: 2024, Номер 20(5), С. 261 - 277
Опубликована: Фев. 6, 2024
Язык: Английский
Процитировано
65
Indian Journal of Clinical Biochemistry, Год журнала: 2023, Номер 39(2), С. 154 - 167
Опубликована: Авг. 1, 2023
Язык: Английский
Процитировано
57
Biomedicines, Год журнала: 2023, Номер 11(1), С. 136 - 136
Опубликована: Янв. 5, 2023
Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have higher risk falls may be associated with heart disease, respiratory diseases, cognitive impairment, consequently an increased hospitalization, in addition causing economic impact high cost care during stay hospitals. The standardization appropriate treatment for patients sarcopenia that could help reduce pathology-related morbidity necessary. For these reasons, this study aimed perform systematic review role nutrition drugs ameliorate health quality life sarcopenic PRISMA guidelines were followed. Lifestyle interventions shown profound on but using supplements different can also skeletal maintenance. Creatine, leucine, branched-chain amino acids, omega 3, vitamin D show benefits. Although controversial results, medications such as Metformin, GLP-1, losartan, statin, growth hormone, dipeptidyl peptidase 4 inhibitors been considered alter sarcopenic's metabolic parameters, protect against cardiovascular diseases outcomes, while protecting muscles.
Язык: Английский
Процитировано
50
Food & Function, Год журнала: 2023, Номер 14(20), С. 9123 - 9136
Опубликована: Янв. 1, 2023
Ginsenosides resist the aging by regulating multiple signaling pathways.
Язык: Английский
Процитировано
28
Annals of Medicine, Год журнала: 2023, Номер 55(2)
Опубликована: Авг. 29, 2023
Aim: To discuss the progress of extracellular matrix (ECM) characteristics, mitochondrial homeostasis, and their potential crosstalk in pathogenesis sarcopenia, a geriatric syndrome characterized by generalized progressive reduction muscle mass, strength, physical performance.Methods: This review focuses on anatomy physiology skeletal muscle, alterations ECM mitochondria during ageing, role interplay between sarcopenia.Results: Emerging evidence points to clear various tissues organs. Under ageing process, undergoes changes composition properties that may mediate via systematic metabolism, ROS, SPARC pathway, AMPK/PGC-1α signalling, which turn exacerbate degeneration. However, precise effects such pathobiology particularly have not yet been fully understood.Conclusion: The are partially responsible for worsened function process. A deeper understanding interactions sarcopenic patients can help prevent sarcopenia improve its prognoses.
Язык: Английский
Процитировано
27
Acta Physiologica, Год журнала: 2024, Номер 240(3)
Опубликована: Фев. 2, 2024
Abstract Sarcopenia lowers the quality‐of‐life for millions of people across world, as accelerated loss skeletal muscle mass and function contributes to both age‐ disease‐related frailty. Physical activity remains only proven therapy sarcopenia date, but alternatives are much sought after manage this progressive disorder in individuals who unable exercise. Mitochondria have been widely implicated etiology increasingly suggested attractive therapeutic targets help restore perturbed balance between protein synthesis breakdown that underpins atrophy. Reviewing current literature, we note mitochondrial bioenergetic changes generally interpreted intrinsic dysfunction renders cells incapable making sufficient ATP fuel synthesis. Based on reported effects interventions, however, argue observed may instead reflect an adaptation pathologically decreased energy expenditure sarcopenic muscle. Discrimination these mechanistic possibilities will be crucial improving management sarcopenia.
Язык: Английский
Процитировано
13
Antioxidants, Год журнала: 2024, Номер 13(1), С. 86 - 86
Опубликована: Янв. 10, 2024
Tendinopathy is a debilitating condition marked by degenerative changes in the tendons. Its complex pathophysiology involves intrinsic, extrinsic, and physiological factors. While its intrinsic extrinsic factors have been extensively studied, role of factors, such as hypoxia oxidative stress, remains largely unexplored. This review article delves into contribution hypoxia-associated genes oxidative-stress-related to tendon degeneration, offering insights potential therapeutic strategies. The unique aspect this study lies pathway-based evidence, which sheds light on how these can be targeted enhance overall health.
Язык: Английский
Процитировано
10
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10535 - 10535
Опубликована: Сен. 30, 2024
Progress made by the medical community in increasing lifespans comes with costs of incidence and prevalence age-related diseases, neurodegenerative ones included. Aging is associated a series morphological changes at tissue cellular levels brain, as well impairments signaling pathways gene transcription, which lead to synaptic dysfunction cognitive decline. Although we are not able pinpoint exact differences between healthy aging neurodegeneration, research increasingly highlights involvement neuroinflammation chronic systemic inflammation (inflammaging) development age-associated via pathogenic cascades, triggered dysfunctions circadian clock, gut dysbiosis, immunosenescence, or impaired cholinergic signaling. In addition, gender susceptibility course neurodegeneration that appear be mediated glial cells emphasize need for future this area an individualized therapeutic approach. rejuvenation still its very early infancy, accumulated knowledge on various involved promoting senescence opens perspective interfering these preventing delaying senescence.
Язык: Английский
Процитировано
10