Cell death checkpoints in the TNF pathway

Trends in Immunology, Год журнала: 2023, Номер 44(8), С. 628 - 643

Опубликована: Июнь 24, 2023

Язык: Английский

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cGAS‐STING signaling in cell death: Mechanisms of action and implications in pathologies

European Journal of Immunology, Год журнала: 2023, Номер 53(9)

Опубликована: Июль 9, 2023

Cyclic GMP-AMP synthase (cGAS) monitors dsDNA in the cytosol response to pathogenic invasion or tissue injury, initiating cGAS-STING signaling cascades that regulate various cellular physiologies, including IFN /cytokine production, autophagy, protein synthesis, metabolism, senescence, and distinct types of cell death. is crucial for host defense homeostasis; however, its dysfunction frequently leads infectious, autoimmune, inflammatory, degenerative, cancerous diseases. Our knowledge regarding relationships between death rapidly evolving, highlighting their essential roles pathogenesis disease progression. Nevertheless, direct control by signaling, rather than IFN/NF-κB-mediated transcriptional regulation, remains relatively unexplored. This review examines mechanistic interplays apoptosis, necroptosis, pyroptosis, ferroptosis, autophagic/lysosomal We will also discuss pathological implications human diseases, particularly autoimmunity, cancer, organ injury scenarios. hope this summary stimulate discussion further exploration complex life-or-death responses damage mediated signaling.

Язык: Английский

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Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases

APOPTOSIS, Год журнала: 2024, Номер 29(9-10), С. 1330 - 1360

Опубликована: Июль 16, 2024

Язык: Английский

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Cell death pathways: molecular mechanisms and therapeutic targets for cancer

MedComm, Год журнала: 2024, Номер 5(9)

Опубликована: Сен. 1, 2024

Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.

Язык: Английский

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Erythronecroptosis: an overview of necroptosis or programmed necrosis in red blood cells

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер 479(12), С. 3273 - 3291

Опубликована: Март 1, 2024

Язык: Английский

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Protein phosphorylation and kinases: Potential therapeutic targets in necroptosis

European Journal of Pharmacology, Год журнала: 2024, Номер 970, С. 176508 - 176508

Опубликована: Март 15, 2024

Язык: Английский

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Sequential immunotherapy: towards cures for autoimmunity

Nature Reviews Drug Discovery, Год журнала: 2024, Номер 23(7), С. 501 - 524

Опубликована: Июнь 5, 2024

Язык: Английский

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Programmed cell death in nasopharyngeal carcinoma: Mechanisms and therapeutic targets

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер 1880(1), С. 189265 - 189265

Опубликована: Янв. 13, 2025

Язык: Английский

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Cell death signaling in human erythron: erythrocytes lose the complexity of cell death machinery upon maturation

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Abstract Over the recent years, our understanding of cell death machinery mature erythrocytes has been greatly expanded. It resulted in discovery several regulated (RCD) pathways red blood cells. Apoptosis (eryptosis) and necroptosis share certain features with their counterparts nucleated cells, but they are also critically different particular details. In this review article, we summarize subroutines erythroid precursors (apoptosis, necroptosis, ferroptosis) comparison to (eryptosis erythronecroptosis) highlight consequences organelle clearance associated loss multiple components upon erythrocyte maturation. Recent advances role RCDs health disease have expanded potential clinical applications these lethal subroutines, emphasizing contribution development anemia, microthrombosis, endothelial dysfunction, as well diagnostic biomarkers markers storage-induced lesions. Fas signaling functional caspase-8/caspase-3 system not indispensable for eryptosis, might be retained mediate crosstalk between both erythrocyte-associated RCDs. The ability switch eryptosis suggests that is a simple unregulated mechanical disintegration, tightly controlled process. This allows investigation eventual pharmacological interventions aimed at individual erythrocytes.

Язык: Английский

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Let’s make it personal: CRISPR tools in manipulating cell death pathways for cancer treatment

Cell Biology and Toxicology, Год журнала: 2024, Номер 40(1)

Опубликована: Июль 29, 2024

Abstract Advancements in the CRISPR technology, a game-changer experimental research, have revolutionized various fields of life sciences and more profoundly, cancer research. Cell death pathways are among most deregulated cells considered as critical aspects development. Through decades, our knowledge mechanisms orchestrating programmed cellular has increased substantially, attributed to revolution cutting-edge technologies. The heroic appearance systems expanded available screening platform genome engineering toolbox detect mutations create precise edits. In that context, ability this system for identification targeting cell signaling result development therapy resistance is an auspicious choice transform accelerate individualized therapy. concept personalized stands on molecular characterization individual tumor its microenvironment order provide treatment with highest possible outcome minimum toxicity. This study explored potential technology precision by identifying specific pathways. It showed promise finding key components involved death, making it tool targeted However, also highlighted challenges limitations need be addressed future research fully realize treatment. Graphical abstract Current application through glance. A choosing appropriate biological model vitro (using established lines, animal derived cells, human stem or T cells), vivo models which can harbor tumor), ex (human/animal-derived organoids). B preparation gRNA library. C design screening, desired gRNAs phenotypic response. D CRISPR-Cas identified targets, Cas9 gene editing (Knockout, base editing, prime editing), RNA modulation (modulation splicing, interference), epigenomic edits interference/activation using dead (dCas9) (Bock et al. 2022b)

Язык: Английский

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