Protein Quality Control Systems and ER Stress as Key Players in SARS-CoV-2-Induced Neurodegeneration
Cells,
Год журнала:
2024,
Номер
13(2), С. 123 - 123
Опубликована: Янв. 9, 2024
The
COVID-19
pandemic
has
brought
to
the
forefront
intricate
relationship
between
SARS-CoV-2
and
its
impact
on
neurological
complications,
including
potential
links
neurodegenerative
processes,
characterized
by
a
dysfunction
of
protein
quality
control
systems
ER
stress.
This
review
article
explores
role
systems,
such
as
Unfolded
Protein
Response
(UPR),
Endoplasmic
Reticulum-Associated
Degradation
(ERAD),
Ubiquitin–Proteasome
System
(UPS),
autophagy
molecular
chaperones,
in
infection.
Our
hypothesis
suggests
that
produces
stress
exploits
leading
disruption
proteostasis
cannot
be
solved
host
cell.
culminates
cell
death
may
represent
link
neurodegeneration.
Язык: Английский
Neurological complications caused by SARS-CoV-2
Clinical Microbiology Reviews,
Год журнала:
2024,
Номер
37(4)
Опубликована: Сен. 18, 2024
SUMMARYSARS-CoV-2
can
not
only
cause
respiratory
symptoms
but
also
lead
to
neurological
complications.
Research
has
shown
that
more
than
30%
of
SARS-CoV-2
patients
present
neurologic
during
COVID-19
(A.
Pezzini
and
A.
Padovani,
Nat
Rev
Neurol
16:636-644,
2020,
https://doi.org/10.1038/s41582-020-0398-3).
Increasing
evidence
suggests
invade
both
the
central
nervous
system
(CNS)
(M.S.
Xydakis,
M.W.
Albers,
E.H.
Holbrook,
et
al.
Lancet
20:
753-761,
2021
https://doi.org/10.1016/S1474-4422(21)00182-4
)
peripheral
(PNS)
(M.N.
Soares,
M.
Eggelbusch,
E.
Naddaf,
J
Cachexia
Sarcopenia
Muscle
13:11-22,
2022,
https://doi.org/10.1002/jcsm.12896),
resulting
in
a
variety
disorders.
This
review
summarized
CNS
complications
caused
by
infection,
including
encephalopathy,
neurodegenerative
diseases,
delirium.
Additionally,
some
PNS
disorders
such
as
skeletal
muscle
damage
inflammation,
anosmia,
smell
or
taste
impairment,
myasthenia
gravis,
Guillain-Barré
syndrome,
ICU-acquired
weakness,
post-acute
sequelae
were
described.
Furthermore,
mechanisms
underlying
SARS-CoV-2-induced
discussed,
entering
brain
through
retrograde
neuronal
hematogenous
routes,
disrupting
normal
function
cytokine
storms,
inducing
cerebral
ischemia
hypoxia,
thus
leading
Moreover,
an
overview
long-COVID-19
is
provided,
along
with
recommendations
for
care
therapeutic
approaches
experiencing
Язык: Английский
A Systems Neuroscience Approach to Diagnosis and Rehabilitation of Post COVID Neurological Syndrome Based on the Systems Neuroscience Test Battery (SNTB) Study Protocol
Neurorehabilitation,
Год журнала:
2025,
Номер
56(1), С. 37 - 47
Опубликована: Фев. 1, 2025
The
proposed
study
reports
the
design
and
development
of
a
rapid
screening
tool,
Systems
Neuroscience
Test
Battery
(SNTB),
for
diagnosing
evaluating
neurological
manifestations
Post-COVID-19
Neurological
Syndrome
(PCNS)
within
broader
context
Post-Acute
Sequelae
to
COVID-19
(PASC).
SNTB
is
designed
incorporate
behaviorally
relevant
Telehealth
component
that
enhances
consumer
confidence
in
symptom
discrimination,
management
PCNS,
guides
rehabilitation
programs
while
allowing
continuous
evaluation
intervention
effectiveness.
employs
longitudinal
design,
with
telehealth
routine
blood
assessments
conducted
at
three-month
intervals,
including
least
two
follow-ups
post-recruitment.
These
will
involve
Consumer-Reported
Symptoms,
Clinical
History,
Neuropsychological
Data,
Timed
Psychophysics,
aimed
PCNS-related
symptoms
‘brain
fog”
its
affect
on
visually
driven
attention,
cognition
motor
behaviors.
are
intended
validate
characteristics
fog’
identify
predictive
behavioral
biomarkers
PCNS.
target
population
includes
adults
aged
18–65
who
have
experienced
persistent
three
months
following
confirmed
infection.
Exclusion
criteria
include
individuals
unable
undergo
radiological
examinations,
such
as
pregnant
women
or
those
contraindications
MRI,
ensuring
robustness
sample
reducing
potential
selection
bias.
tool
facilitate
online
identification
PCNS
aid
discovery
effective
molecular
biomarker
combinations
medical
rehabilitation.
Complementary
Assessment,
hospital
facilities
be
utilized
blood-based
assessments,
concurrent
profiling
structural
functional
changes
during
recovery
from
symptoms.
Язык: Английский
Re-visiting mpox: Stealth Assault on the Brain and Emerging Biomedical Research Insights
Brain Disorders,
Год журнала:
2024,
Номер
unknown, С. 100169 - 100169
Опубликована: Окт. 1, 2024
Язык: Английский
Drug Repurposing for COVID-19 by Constructing a Comorbidity Network with Central Nervous System Disorders
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8917 - 8917
Опубликована: Авг. 16, 2024
In
the
post-COVID-19
era,
treatment
options
for
potential
SARS-CoV-2
outbreaks
remain
limited.
An
increased
incidence
of
central
nervous
system
(CNS)
disorders
has
been
observed
in
long-term
COVID-19
patients.
Understanding
shared
molecular
mechanisms
between
these
conditions
may
provide
new
insights
developing
effective
therapies.
This
study
developed
an
integrative
drug-repurposing
framework
COVID-19,
leveraging
comorbidity
data
with
CNS
disorders,
network-based
modular
analysis,
and
dynamic
perturbation
analysis
to
identify
drug
targets
candidates
against
SARS-CoV-2.
We
constructed
a
network
based
on
literature
collection,
including
COVID-19-related
proteins
genes
associated
Alzheimer’s
disease,
Parkinson’s
multiple
sclerosis,
autism
spectrum
disorder.
Functional
module
detection
annotation
identified
primarily
involved
protein
synthesis
as
key
target
module,
utilizing
connectivity
map
data.
Through
construction
weighted
drug–target
ubiquitin–carboxy-terminal
hydrolase
L1
emerged
target.
Molecular
dynamics
simulations
suggested
pregnenolone
BRD-K87426499
two
COVID-19.
introduces
dynamic-perturbation-network-based
approach
by
incorporating
disorders.
Язык: Английский
Severity and Mortality in Maintenance Hemodialysis Patients Infected with COVID-19 Omicron Strain: a Single-Centered, Retrospective Study in China
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 28, 2024
Abstract
Purpose
The
aim
of
this
study
was
to
observe
the
characteristics
COVID-19
infected
maintenance
hemodialysis
(MHD)
patients,
identify
risk
factors
for
severe
illness
and
mortality
in
population,
establish
a
preliminary
prediction
model
infection
MHD
patients.
Methods
We
included
patients
who
underwent
long-term
were
hospitalized
at
our
hospital
from
December
2022
March
2023.
retrospectively
analyzed
their
demographic
characteristics,
clinical
manifestations,
laboratory
tests,
hemodialysis-related
information,
treatment
strategies
complications.
divided
into
(heavy
critical)
non-severe
(mild
moderate)
groups.
Logistic
regression
Cox
proportional
hazards
analysis
used
progression.
Results
presence
cerebrovascular
disease,
elevated
NLR,
fibrinogen,
D-dimer
are
independent
indicators
early
stage.
diabetes,
NLR
associated
with
mortality.
Conclusion
have
high
probability
developing
critical
infection,
can
serve
as
warning
progression
infection.
levels
attribute
worse
outcomes
increased
Язык: Английский
A case series of COVID-19-related catatonia: A focus on immunological and neural mechanisms
Psychiatry Research Case Reports,
Год журнала:
2024,
Номер
3(1), С. 100222 - 100222
Опубликована: Апрель 2, 2024
COronaVIrus
Disease
19
(COVID-19)
has
led
to
a
global
health
crisis
and
dramatically
changed
people's
lifestyles.
Several
neuropsychiatric
complications,
including
catatonia,
have
been
reported
as
either
para-
or
post-infectious
complications
of
COVID-19.
We
describe
three
cases
catatonia
associated
with
COVID-19,
presenting
distinct
psychiatric
histories
medical
contexts.
Putative
pathogenic
mechanisms
COVID-19-related
involve
combination
direct
viral
neuronal
damage
neuroinflammation
secondary
cytokine
storm.
Severe
acute
respiratory
syndrome
coronavirus
2
can
reach
the
central
nervous
system
via
axonal
transport
along
sensory
nerves
haematogenous
spread.
The
pathways
activated
by
infection
may
also
affect
neurotransmission
in
basal
ganglia
involving
gamma-aminobutyric
acid,
dopamine,
glutamate
systems.
In
some
cases,
COVID-19
lead
anti-NMDA
receptor
encephalitis
activating
molecular
mimicry.
These
highlight
importance
appropriate
screening
manifestations
after
early
diagnosis
catatonia.
Therapeutic
strategies
include
use
benzodiazepines
electroconvulsive
therapy
first-line
treatments
for
although
concerns
related
poor
response
infections.
Mounting
evidence
suggests
that
augmentation
NMDA
antagonist
is
useful
therapeutic
option,
especially
treatment-resistant
Язык: Английский