Journal of General Virology, Год журнала: 2024, Номер 105(12)
Опубликована: Дек. 17, 2024
The Bombyx mori nucleopolyhedrovirus (BmNPV) is a DNA virus that affects the silkworm,
Язык: Английский
Journal of General Virology, Год журнала: 2024, Номер 105(12)
Опубликована: Дек. 17, 2024
The Bombyx mori nucleopolyhedrovirus (BmNPV) is a DNA virus that affects the silkworm,
Язык: Английский
Cell Calcium, Год журнала: 2025, Номер 128, С. 103032 - 103032
Опубликована: Апрель 18, 2025
Язык: Английский
Процитировано
1Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Язык: Английский
Процитировано
0Exploration of neuroscience, Год журнала: 2025, Номер 4
Опубликована: Март 24, 2025
The SAR-CoV-2 virus has evolved to co-exist with human hosts, albeit at a substantial energetic cost resulting in post-infection neurological manifestations [Neuro-post-acute sequelae of SARS-CoV-2 infection (PASC)] that significantly impact public health and economic productivity on global scale. One the main molecular mechanisms responsible for development Neuro-PASC, individuals all ages, is formation inadequate proteolysis/clearance phase-separated amyloid crystalline aggregates—a hallmark feature aging-related neurodegenerative disorders. Amyloidogenesis during viral persistence natural, inevitable, protective defense response exacerbated by SARS-CoV-2. Acting as chemical catalyst, accelerates hydrophobic collapse heterogeneous nucleation amorphous amyloids into stable β-sheet aggregates. clearance aggregates most effective slow wave sleep, when high levels adenosine triphosphate (ATP)—a biphasic modulator biomolecular condensates—and melatonin are available solubilize removal. dysregulation mitochondrial dynamics SARS-CoV-2, particular fusion fission homeostasis, impairs proper distinct subpopulations can remedy challenges created diversion substrates away from oxidative phosphorylation towards glycolysis support replication maintenance. subsequent reduction ATP inhibition synthesis sleep results incomplete brain aggregates, leading commonly associated age-related Exogenous not only prevents dysfunction but also elevates production, effectively augmenting solubilizing effect moiety ensure timely, optimal disaggregation pathogenic prevention attenuation Neuro-PASC.
Язык: Английский
Процитировано
0Biochimica et Biophysica Acta (BBA) - General Subjects, Год журнала: 2025, Номер unknown, С. 130801 - 130801
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0Biomolecules, Год журнала: 2025, Номер 15(4), С. 514 - 514
Опубликована: Апрель 1, 2025
Aging is the result of various compounding stresses that gradually overcome homeostatic regulation cell, resulting in irreversible damage. This manifests as many acute and chronic conditions, most common which are neurodegeneration dementia. Epidemiological studies have shown significant, strong correlations between viral infection neurodegenerative diseases. review overlays characteristics pathogenesis with hallmarks aging to discuss how active latent viruses contribute aging. Through our contextualization myriad basic science papers, we offer explanations for premature via induction stress response pathways. Viruses induce stresses: dysregulated homeostasis by exogenous proteins overwhelmed protein quality control mechanisms, DNA damage through direct integration epigenetic manipulation, immune-mediated oxidative immune exhaustion, general energy theft amplified an system. Overall, this highlights long-term importance vaccines antivirals addition their benefits.
Язык: Английский
Процитировано
0Virology Journal, Год журнала: 2025, Номер 22(1)
Опубликована: Май 30, 2025
Язык: Английский
Процитировано
0Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Июль 25, 2024
The average lifespan of humans has been increasing, resulting in a rapidly rising percentage older individuals and high morbidity aging-associated diseases, especially cardiovascular diseases (CVDs). Diverse intracellular extracellular factors that interrupt homeostatic functions the endoplasmic reticulum (ER) induce ER stress. Cells employ dynamic signaling pathway unfolded protein response (UPR) to buffer Recent studies have demonstrated stress triggers various cellular processes associated with aging many including CVDs. Autophagy is conserved process involving lysosomal degradation recycling cytoplasmic components, proteins, organelles, pathogens invade cytoplasm. vital for combating adverse influence on heart. present report summarizes recent mechanism autophagy their overlap CVD pathogenesis context aging. It also discusses possible therapeutic interventions targeting might delay prevent or treat
Язык: Английский
Процитировано
3Опубликована: Фев. 29, 2024
Acute HSV-1 infection is associated with mild symptom, such as fever and lesions of the mouth, face skin. This phase followed by a latency period before reactivation which symptoms ranging from ulcers to encephalitis. Despite available anti-HSV-1 drugs, development new antiviral agents sought due presence resistant viruses. Melatonin, molecule secreted pineal gland, has been shown be an antioxidant, inducer antioxidant enzymes, regulator various biological processes. Clinical trials have explored its therapeutic utility in conditions including infections. study focuses on melatonin's role replication underlying mechanisms. Melatonin was found decrease synthesis proteins infected Vero cells measured inmunofluorescence indicating inhibition replication. Additionally, it regulates activities enzymes affects proteasome activity. activates unfolded protein response (UPR) autophagy suppresses apoptosis HSV-1-infected cells. In summary, melatonin demonstrates inhibitory modulating cellular responses, suggesting potential treatment viral
Язык: Английский
Процитировано
2International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 4037 - 4037
Опубликована: Апрель 4, 2024
Acute HSV-1 infection is associated with mild symptoms, such as fever and lesions of the mouth, face skin. This phase followed by a latency period before reactivation, which symptoms ranging from ulcers to encephalitis. Despite available anti-HSV-1 drugs, development new antiviral agents sought due presence resistant viruses. Melatonin, molecule secreted pineal gland, has been shown be an antioxidant, inducer antioxidant enzymes, regulator various biological processes. Clinical trials have explored its therapeutic utility in conditions including infections. study focuses on melatonin’s role replication underlying mechanisms. Melatonin was found decrease synthesis proteins infected Vero cells measured immunofluorescence, indicating inhibition replication. Additionally, it regulates activities enzymes affects proteasome activity. activates unfolded protein response (UPR) autophagy suppresses apoptosis HSV-1-infected cells. In summary, melatonin demonstrates inhibitory modulating cellular responses, suggesting potential treatment viral
Язык: Английский
Процитировано
2Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(4), С. 3383 - 3393
Опубликована: Июль 20, 2024
Язык: Английский
Процитировано
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