TP53 Gene Status can Promote Sensitivity and Resistance to Chemotherapeutic Drugs and Small Molecule Signal Transduction Inhibitors. DOI
James A. McCubrey, Matilde Y. Follo, Stefano Ratti

и другие.

Advances in Biological Regulation, Год журнала: 2024, Номер unknown, С. 101073 - 101073

Опубликована: Дек. 1, 2024

Язык: Английский

The Role of SWI/SNF Complex in Bladder Cancer DOI Creative Commons

Zhenlain Lei,

Yanfeng Han, John B. Liao

и другие.

Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(1)

Опубликована: Янв. 1, 2025

ABSTRACT Bladder cancer originates from bladder tissues and is the ninth most common type of worldwide. The SWI/SNF (SWItch/sucrose non‐ fermentable) complex plays a crucial role in regulating various biological processes, such as cell cycle control, DNA damage repair transcription regulation. purpose this article to examine functional studies cancer, highlighting new pathways for creating personalised treatment approaches patients with mutations complex. By acquiring comprehensive understanding mechanisms we can offer more precise effective solutions treat disease.

Язык: Английский

Процитировано

2
Chromatin remodeling and cancer: the critical influence of the SWI/SNF complex DOI Creative Commons

Fengxiang Hao,

Ying Zhang,

Jiayi Hou

и другие.

Epigenetics & Chromatin, Год журнала: 2025, Номер 18(1)

Опубликована: Апрель 23, 2025

The SWI/SNF complex was first identified in yeast and named after studies of mutants critical for the mating-type switch (SWI) sucrose non-fermenting (SNF) pathways.The plays a pivotal role regulating gene expression by altering chromatin structure to promote or suppress specific genes, maintain stem cell pluripotency, participate various biological processes. Mutations are highly prevalent human cancers, significantly impacting tumor suppressive oncogenic functions influencing initiation progression. This review focuses on mechanisms which ARID1A/ARID1B, PBRM1, SMARCB1, SMARCA2/SMARCA4 contribute cancer, immunoregulatory roles complex, its involvement DNA repair pathways, synthetic lethality, applications precision oncology.

Язык: Английский

Процитировано

0
ARID1A loss sensitizes colorectal cancer cells to floxuridine DOI

Cheng Xiang,

Zhen Wang,

Yingnan Yu

и другие.

Neoplasia, Год журнала: 2024, Номер 58, С. 101069 - 101069

Опубликована: Окт. 17, 2024

Язык: Английский

Процитировано

0
ARID1A recruits GATA2 to regulate the senescence of trophoblast cells under high-glucose condition DOI
Yanyi Huang,

Xiting Yang,

Yuexiao Wang

и другие.

Placenta, Год журнала: 2024, Номер 158, С. 156 - 164

Опубликована: Окт. 21, 2024

Язык: Английский

Процитировано

0
TP53 Gene Status can Promote Sensitivity and Resistance to Chemotherapeutic Drugs and Small Molecule Signal Transduction Inhibitors. DOI
James A. McCubrey, Matilde Y. Follo, Stefano Ratti

и другие.

Advances in Biological Regulation, Год журнала: 2024, Номер unknown, С. 101073 - 101073

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

0