TP53 Gene Status can Promote Sensitivity and Resistance to Chemotherapeutic Drugs and Small Molecule Signal Transduction Inhibitors. DOI
James A. McCubrey, Matilde Y. Follo, Stefano Ratti

et al.

Advances in Biological Regulation, Journal Year: 2024, Volume and Issue: unknown, P. 101073 - 101073

Published: Dec. 1, 2024

Language: Английский

The Role of SWI/SNF Complex in Bladder Cancer DOI Creative Commons

Zhenlain Lei,

Yanfeng Han, John B. Liao

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(1)

Published: Jan. 1, 2025

ABSTRACT Bladder cancer originates from bladder tissues and is the ninth most common type of worldwide. The SWI/SNF (SWItch/sucrose non‐ fermentable) complex plays a crucial role in regulating various biological processes, such as cell cycle control, DNA damage repair transcription regulation. purpose this article to examine functional studies cancer, highlighting new pathways for creating personalised treatment approaches patients with mutations complex. By acquiring comprehensive understanding mechanisms we can offer more precise effective solutions treat disease.

Language: Английский

Citations

2
Chromatin remodeling and cancer: the critical influence of the SWI/SNF complex DOI Creative Commons

Fengxiang Hao,

Ying Zhang,

Jiayi Hou

et al.

Epigenetics & Chromatin, Journal Year: 2025, Volume and Issue: 18(1)

Published: April 23, 2025

The SWI/SNF complex was first identified in yeast and named after studies of mutants critical for the mating-type switch (SWI) sucrose non-fermenting (SNF) pathways.The plays a pivotal role regulating gene expression by altering chromatin structure to promote or suppress specific genes, maintain stem cell pluripotency, participate various biological processes. Mutations are highly prevalent human cancers, significantly impacting tumor suppressive oncogenic functions influencing initiation progression. This review focuses on mechanisms which ARID1A/ARID1B, PBRM1, SMARCB1, SMARCA2/SMARCA4 contribute cancer, immunoregulatory roles complex, its involvement DNA repair pathways, synthetic lethality, applications precision oncology.

Language: Английский

Citations

0
ARID1A loss sensitizes colorectal cancer cells to floxuridine DOI

Cheng Xiang,

Zhen Wang,

Yingnan Yu

et al.

Neoplasia, Journal Year: 2024, Volume and Issue: 58, P. 101069 - 101069

Published: Oct. 17, 2024

Language: Английский

Citations

0
ARID1A recruits GATA2 to regulate the senescence of trophoblast cells under high-glucose condition DOI
Yanyi Huang,

Xiting Yang,

Yuexiao Wang

et al.

Placenta, Journal Year: 2024, Volume and Issue: 158, P. 156 - 164

Published: Oct. 21, 2024

Language: Английский

Citations

0
TP53 Gene Status can Promote Sensitivity and Resistance to Chemotherapeutic Drugs and Small Molecule Signal Transduction Inhibitors. DOI
James A. McCubrey, Matilde Y. Follo, Stefano Ratti

et al.

Advances in Biological Regulation, Journal Year: 2024, Volume and Issue: unknown, P. 101073 - 101073

Published: Dec. 1, 2024

Language: Английский

Citations

0