Amino acid transporters within the solute carrier superfamily: Underappreciated proteins and novel opportunities for cancer therapy
Molecular Metabolism,
Год журнала:
2024,
Номер
84, С. 101952 - 101952
Опубликована: Май 3, 2024
Solute
carrier
(SLC),
a
diverse
family
of
membrane
proteins,
are
instrumental
in
orchestrating
the
intake
and
efflux
nutrients
including
amino
acids,
vitamins,
ions,
nutrients,
etc,
across
cell
membranes.
This
dynamic
process
is
critical
for
sustaining
metabolic
demands
cancer
cells,
promoting
their
survival,
proliferation,
adaptation
to
tumor
microenvironment.
Amino
acids
fundamental
building
blocks
playing
essential
roles
not
only
protein
synthesis
but
also
nutrient
sensing,
signaling
pathways
that
can
promote
tumorigenesis.
As
key
transporters
SLCs
have
emerged
as
crucial
players
maintaining
cellular
acid
homeostasis,
dysregulation
implicated
various
types.
Thus,
understanding
intricate
connections
between
SLCs,
pivotal
unraveling
novel
therapeutic
targets
strategies.
uptake
by
positively
affects
progression.
However,
some
studies
revealed
suppressor
function
SLCs.
Although
body
evaluated
SLC7A11
SLC1A5,
SLC
proteins
studied
sufficiently
cancer.
In
this
review,
we
delve
into
significant
impact
carriers
on
growth
progression
explore
current
state
knowledge
field,
shedding
light
molecular
mechanisms
underlie
these
relationships
highlighting
potential
avenues
future
research
clinical
interventions.
comprehensive
review
provides
insights
rapidly
evolving
area
biology
focusing
one
most
important
materials
cells
need,
within
superfamily.
Язык: Английский
RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer
Clinical and Translational Medicine,
Год журнала:
2025,
Номер
15(2)
Опубликована: Фев. 1, 2025
Язык: Английский
Chitosan-based hydrogels in cancer therapy: Drug and gene delivery, stimuli-responsive carriers, phototherapy and immunotherapy
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
282, С. 137047 - 137047
Опубликована: Ноя. 1, 2024
Язык: Английский
Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 7, 2025
The
5-methylcytosine
(m5C)
modification
is
a
crucial
epigenetic
RNA
modification,
which
involved
in
the
post-transcriptional
regulation
of
genes.
It
plays
an
important
role
various
biological
processes,
including
cell
metabolism,
growth,
apoptosis,
and
tumorigenesis.
By
affecting
proliferation,
migration,
invasion,
drug
sensitivity
tumor
cells,
m5C
methylation
vital
part
initiation
progression
tumors
closely
associated
with
poor
prognosis.
m5C-related
proteins
are
categorized
into
three
functional
groups:
methyltransferases
(m5C
writers),
demethylases
erasers),
methyl-binding
readers).
This
paper
introduces
several
common
methodologies
for
detecting
methylation;
reviews
molecular
structure
functions
readers,
ALYREF,
YBX1,
YBX2,
RAD52,
YTHDF2,
FMRP,
SRSF2.
further
summarizes
their
roles
regulatory
mechanisms
tumors,
offering
novel
targets
insights
treatment.
Язык: Английский
Upregulation of TTYH3 by lncRNA LUCAT1 through interacting with ALYREF facilitates the metastasis in non-small cell lung cancer
Cancer Biology & Therapy,
Год журнала:
2025,
Номер
26(1)
Опубликована: Фев. 10, 2025
Metastasis
is
the
predominant
culprit
of
cancer-associated
mortality
in
non-small
cell
lung
cancer
(NSCLC).
Tweety
homolog
3
(TTYH3)
reportedly
functions
vitally
development
diverse
cancers,
including
NSCLC;
nevertheless,
its
role
NSCLC
metastasis
remains
ambiguous.
Quantitative
reverse
transcription
polymerase
chain
reaction
(qRT-PCR)
and
western
blot
were
initially
employed
to
detect
TTYH3
expression
normal
epithelial
cells.
Subsequently,
A549
NCI-H1650
cells
chosen
as
models
vitro
transfected
with
short
hairpin
RNAs
(sh-TTYH3,
sh-LUCAT1,
sh-ALYREF)
or
overexpression
plasmids
(oe-ALYREF
oe-TTYH3).
Transwell
assays
used
for
migrative
invasive
tests.
Epithelial
mesenchymal
transformation
(EMT)-related
proteins
(E-cadherin,
N-cadherin,
Vimentin,
Snail)
measured
by
blot.
A
mouse
model
was
built
define
function
metastasis,
followed
hematoxylin-eosin
staining.
RNA
pull-down,
immunoprecipitation,
qRT-PCR,
blot,
actinomycin
D
adopted
determine
relationships
among
LUCAT1,
ALYREF,
TTYH3.
highly
expressed
relative
Functionally,
knockdown
restrained
migration,
invasion,
EMT,
metastasis.
Mechanistic
experiments
demonstrated
that
LUCAT1
bound
ALYREF.
After
knockdown,
mRNA
stability
reduced,
which
reversed
ALYREF
overexpression.
Furthermore,
counteracted
inhibitory
effects
on
EMT.
eliminated
suppressive
downregulation
progression.
promotes
via
interacting
thereby
facilitating
Язык: Английский
The multifaceted role of m5C RNA methylation in digestive system tumorigenesis
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Март 6, 2025
5-Methylcytosine
(m5C)
is
a
widespread
RNA
methylation
modification,
wherein
methyl
group
enzymatically
transferred
to
specific
sites
by
methyltransferases,
such
as
the
NSUN
family
and
DNMT2.
The
m5C
modification
not
only
impacts
structure
stability
but
also
governs
post-transcriptional
regulation
influencing
transport,
translation,
protein
interactions.
Recently,
functional
importance
of
in
complex
diseases,
including
cancer,
has
gained
substantial
attention.
Increasing
evidence
highlights
critical
roles
digestive
system
malignancies,
where
it
contributes
tumor
progression
modulating
oncogene
expression
regulating
processes
cell
proliferation,
migration,
invasion,
resistance
chemotherapy.
Furthermore,
m5C's
involvement
non-coding
RNAs
reveals
additional
dimensions
elucidating
their
cancer.
This
review
summarizes
recent
advances
research
within
tumors,
focusing
on
its
mechanisms,
clinical
significance,
potential
applications.
Specifically,
aims
explore
role
diagnosis,
prognosis,
treatment,
while
proposing
future
directions
address
current
challenges
broaden
utility.
Язык: Английский
TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Сен. 20, 2024
Cardiac
maladaptive
remodeling
is
one
of
the
leading
causes
heart
failure
with
highly
complicated
pathogeneses.
The
E3
ligase
tripartite
motif
containing
35
(TRIM35)
has
been
identified
as
a
crucial
regulator
governing
cellular
growth,
immune
responses,
and
metabolism.
Nonetheless,
role
TRIM35
in
fibroblasts
cardiac
remains
elusive.
Язык: Английский
Significant roles of RNA 5-methylcytosine methylation in cancer
Cellular Signalling,
Год журнала:
2024,
Номер
126, С. 111529 - 111529
Опубликована: Ноя. 28, 2024
Язык: Английский
Uncovering key genes and molecular mechanisms of dendritic cell dysfunction in Esophageal Cancer: implications for Novel Diagnostic and therapeutic strategies
Discover Oncology,
Год журнала:
2024,
Номер
15(1)
Опубликована: Дек. 18, 2024
Dendritic
cells
play
a
crucial
role
in
initiating
and
regulating
immune
responses,
their
dysfunction
is
strongly
associated
with
esophageal
cancer.
In
this
study,
we
aimed
to
develop
predictive
signature
identify
key
genes
linked
dendritic
cell
Through
bioinformatics
analysis
of
gene
expression
data
from
the
TCGA
database,
identified
set
603
significantly
function.
Further
using
Cox
regression
LASSO
revealed
six
(GDF15,
GPT,
KRTAP5-5,
MMP12,
SLC5A1,
C5orf52)
that
were
correlated
overall
survival.
The
prognostic
constructed
these
demonstrated
patients
high-risk
group
had
poorer
survival
outcomes
compared
those
low-risk
group.
Immune
infiltration
indicated
higher
abundance
macrophages
group,
correlation
studies
showed
strong
positive
association
between
risk
score
checkpoint
markers
PD1
PD-L1.
Drug
sensitivity
suggested
Metformin,
Gefitinib,
Lapatinib
may
be
more
effective
while
Pyrimethamine,
Axitinib,
Rapamycin
beneficial
for
patients.
summary,
6-gene
related
can
predict
prognosis
cancer,
offering
valuable
insights
personalized
therapeutic
strategies.
Язык: Английский