Topics in medicinal chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18
Published: Jan. 31, 2025
Advancements in tissue regeneration, particularly bone regeneration is key area of research due to potential novel therapeutic approaches. Efforts reduce reliance on autologous and allogeneic grafts have led the development biomaterials that promote synchronized controlled healing. However, use growth factors limited by their short half-life, slow penetration, large molecular size toxicity. These suggest traditional delivery methods may be inadequate hence, address these challenges, new strategies are being explored. approaches include bioactive substances within advanced systems enable precise spatiotemporal control. Dual-release composite scaffolds offer a promising solution reducing need for multiple surgical interventions simplifying treatment process. allow sustained drug release, enhancing repair while minimizing drawbacks conventional methods. This review explores various dual-drug release systems, discussing modes action, types drugs used mechanisms improve regeneration.
Language: Английский
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Regenerative Therapy, Journal Year: 2025, Volume and Issue: 28, P. 558 - 572
Published: Feb. 13, 2025
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 453 - 453
Published: April 1, 2025
Background/Objectives: This study aimed to explore the therapeutic potential of umbilical mesenchymal stem cell-derived apoptotic vesicles (UMSC-apoVs) in a 5-Fluorouracil (5-FU)-induced impairment skin wound healing. Methods: UMSC-apoVs were isolated from UMSCs using differential centrifugation after induction apoptosis. A murine model was established by administering 5-FU via intravenous tail injection, followed full-thickness creation. Mice received local injections at lesion site. Wound healing evaluated based on closure rates, histological analysis, and vivo/in vitro functional assays. Rotenone (Rot)-pretreated used role mitochondrial transfer between cells (SMSCs) Results: significantly accelerated 5-FU-treated mice, as demonstrated enhanced rates findings reduced inflammatory infiltration increased collagen deposition. transferred mitochondria SMSCs, enhancing viability, proliferation, migration while reducing reactive oxygen species (ROS) production SMSCs. Rot pretreatment inhibited effects inducing dysfunction UMSC-apoVs. Conclusions: Our indicate that improve 5-FU-induced impaired facilitating transfer, suggesting novel strategy for alleviating chemotherapy-induced
Language: Английский
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Regenerative Therapy, Journal Year: 2025, Volume and Issue: 29, P. 303 - 318
Published: April 5, 2025
Language: Английский
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Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 52, P. 85 - 96
Published: April 11, 2025
Language: Английский
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International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125592 - 125592
Published: April 1, 2025
Language: Английский
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Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Sept. 5, 2024
Observational studies have indicated a potential association between autoimmune diseases and the occurrence of Osteoarthritis (OA), with an increased risk mortality among affected patients. However, whether causal relationship exists two remains unknown.
Language: Английский
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Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2478 - 2478
Published: Oct. 28, 2024
Background/Objectives: Osteoarthritis (OA) is a prevalent and debilitating joint disorder characterized by progressive cartilage degradation inflammation, for which traditional treatments offer only symptomatic relief without halting disease progression. Exosomes, cell-free vesicles derived from mesenchymal stem cells, have emerged as promising alternative therapy owing to their regenerative anti-inflammatory properties. Methods: This review synthesizes findings recent studies (2017–2023) on the therapeutic potential of exosomes in OA treatment, highlighting ability modulate microenvironment, reduce promote repair delivering bioactive molecules such cytokines, growth factors, regulatory ribonucleic acids. Results: We explore integration with biomaterials, hydrogels scaffolds, enhance delivery efficacy, we address critical challenges associated clinical application, including standardization isolation characterization methods, scalability production, mechanistic understanding, long-term safety. Despite these challenges, exosome-based therapies several advantages over cell-based treatments, lower immunogenicity, ease handling, targeted agents damaged tissues. Conclusions: provide an analytical perspective current state exosome research OA, emphasizing need standardized production deeper insights, rigorous safety assessments. Future directions should focus optimizing systems, exploring personalized medicine approaches, conducting comparative effectiveness fully realize treatment. Addressing gaps will be crucial translating bench bedside achieving transformative impact management.
Language: Английский
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Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 18, 2024
Extracellular vesicles (EV) can be produced as part of pathology and physiology with increased amounts in pathological conditions. EVs carry transfer cargo such proteins, nucleic acids, lipids to target cells mediate intercellular communication resulting modulation gene expression, signaling pathways, phenotype recipient cells. greatly influence the extracellular environment immune response. Their immunomodulatory properties are crucial rheumatoid arthritis (RA), a condition marked by dysregulated modulate functions innate adaptive RA pathogenesis. Differentially expressed EV-associated molecules RA, microRNAs (miRNAs), long-noncoding RNAs (lncRNAs), messenger (mRNAs) proteins promising markers diagnose disease. miRNA, lncRNA, circular RNA (circRNA) cargos EV regulate inflammation pathogenic fibroblast-like synoviocytes (RA-FLS). Downregulated tissue drugs encapsulated for therapy. This review provides an updated overview EVs’ immunomodulatory, diagnostic, therapeutic roles, particularly emphasizing mesenchymal stem cell-derived (MSC-EVs).
Language: Английский
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Topics in medicinal chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0