Nature Reviews Neurology, Год журнала: 2024, Номер 20(2), С. 67 - 83
Опубликована: Янв. 9, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)
Опубликована: Апрель 22, 2022
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing clinical trials have demonstrated that innate adaptive immune responses can promote or quell atherosclerosis. Several signaling pathways, are associated the response, been implicated within atherosclerosis such as NLRP3 inflammasome, toll-like receptors, proprotein convertase subtilisin/kexin type 9, Notch Wnt which of importance for development regression. Targeting especially inflammasome pathway its regulated cytokine interleukin-1β, could represent an attractive new route treatment atherosclerotic diseases. Herein, we summarize knowledge on cellular participants key pathways in atherosclerosis, discuss preclinical studies targeting these going to target some processes, effects quelling inflammation clinic.
Язык: Английский
Процитировано
589
Nature reviews. Cancer, Год журнала: 2021, Номер 21(8), С. 481 - 499
Опубликована: Июнь 3, 2021
Язык: Английский
Процитировано
547
Theranostics, Год журнала: 2022, Номер 12(9), С. 4310 - 4329
Опубликована: Янв. 1, 2022
Pyroptosis is a lytic and inflammatory type of programmed cell death that usually triggered by inflammasomes executed gasdermin proteins. The main characteristics pyroptosis are swelling, membrane perforation, the release contents. In normal physiology, plays critical role in host defense against pathogen infection. However, excessive may cause immoderate continuous responses involves occurrence diseases. Attractively, as immunogenic death, can serve new strategy for cancer elimination inducing pyroptotic activating intensely antitumor immunity. To make good use this double-edged sword, molecular mechanisms, therapeutic implications related diseases need to be fully elucidated. review, we first systematically summarize signaling pathways then present available evidences indicating cancer. Based on this, focus recent progress strategies inhibit treatment diseases, those induce therapy. Overall, should shed light future directions provide novel ideas using powerful tool fight
Язык: Английский
Процитировано
344
Biomedicines, Год журнала: 2021, Номер 9(5), С. 524 - 524
Опубликована: Май 7, 2021
Alzheimer's disease (AD) is a neurodegenerative associated with human aging. Ten percent of individuals over 65 years have AD and its prevalence continues to rise increasing age. There are currently no effective modifying treatments for AD, resulting in increasingly large socioeconomic personal costs. Increasing age an increase low-grade chronic inflammation (inflammaging) that may contribute the process AD. Although exact mechanisms remain unclear, aberrant elevation reactive oxygen nitrogen species (RONS) levels from several endogenous exogenous processes brain not only affect cell signaling, but also trigger cellular senescence, inflammation, pyroptosis. Moreover, compromised immune privilege allows infiltration peripheral cells infectious agents play role. Additionally, meta-inflammation as well gut microbiota dysbiosis drive neuroinflammatory process. Considering inflammatory/immune pathways dysregulated parallel cognitive dysfunction elucidating relationship between central nervous system facilitate development safe therapy We discuss some current ideas on inflammaging appear summarize details few immunomodulatory strategies being developed selectively target detrimental aspects neuroinflammation without affecting defense against pathogens tissue damage.
Язык: Английский
Процитировано
209
Annual Review of Pathology Mechanisms of Disease, Год журнала: 2021, Номер 17(1), С. 345 - 365
Опубликована: Ноя. 9, 2021
The involvement of inflammasomes in the proinflammatory response observed chronic liver diseases, such as alcohol-associated disease (ALD) and nonalcoholic fatty (NAFLD), is widely recognized. Although there are different types inflammasomes, most studies to date have given attention NLRP3 (nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3) pathogenesis ALD, NAFLD/nonalcoholic steatohepatitis, fibrosis. Canonical intracellular multiprotein complexes that assembled after sensing danger signals activate caspase-1, which matures interleukin (IL)-1β, IL-18, IL-37 also induces a form cell death called pyroptosis. Noncanonical caspase-11 induce We discuss involved diseases with focus on (a) mechanisms inflammasome activation, (b) role their products (c) potential therapeutic strategies targeting components or cytokines produced upon activation.
Язык: Английский
Процитировано
184
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Авг. 11, 2022
Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate acquired immune response. IL-18 produced by both hematopoietic non-hematopoietic cells, including monocytes, macrophages, keratinocytes mesenchymal cell. could potentially induce inflammatory cytotoxic cell activities leading to autoimmunity. Its elevated levels have been reported blood of patients with some immune-related diseases, rheumatoid arthritis, systemic lupus erythematosus, type I diabetes mellitus, atopic dermatitis, psoriasis, bowel disease. In present review, we aimed summarize biological properties its pathological role different autoimmune diseases. We also monoclonal antibodies drugs targeting IL-18. Most these only partial effectiveness or complete ineffectiveness vitro, vivo human studies. The may be largely due loophole caused involvement other cytokines proteins signaling pathway many diseases besides Combination drug therapies, that focus on inhibition, addition cytokines, are highly recommended considered as an important area research needs explored.
Язык: Английский
Процитировано
180
Chemical Reviews, Год журнала: 2021, Номер 122(20), С. 15767 - 15821
Опубликована: Июль 21, 2021
Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane most Gram-negative bacteria, playing fundamental role in protection bacteria from environmental stress factors, drug resistance, pathogenesis, and symbiosis. During last decades, LPS has been thoroughly dissected, massive information on this fascinating biomolecule now available. In Review, we will give reader third millennium update current knowledge with key inherent peculiar carbohydrate chemistry due to often puzzling sugar residues that are uniquely found it. Then, drive through complex multifarious immunological outcomes any given can raise, which strictly dependent its chemical structure. Further, argue about issues still remain unresolved would represent immediate future research. It critical address these points complete our notions chemistry, functions, roles, turn leading innovative ways manipulate processes involving such controversial intriguing biomolecule.
Язык: Английский
Процитировано
170
Frontiers in Pharmacology, Год журнала: 2021, Номер 12
Опубликована: Март 10, 2021
The prevalence of neurodegenerative disease has increased significantly in recent years, and with a rapidly aging global population, this trend is expected to continue. These diseases are characterised by progressive neuronal loss the brain or peripheral nervous system, generally involve protein aggregation, as well metabolic abnormalities immune dysregulation. Although vast majority neurodegeneration idiopathic, there many known genetic environmental triggers. In past decade, research exploring low-grade systemic inflammation its impact on development progression increased. A particular focus been whether arises only secondary effect also cause pathology. inflammasomes, more specifically NLRP3 inflammasome, crucial component innate usually activated response infection tissue damage. Dysregulation inflammasome implicated several disorders, such Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis, prion diseases. This review aims summarise current literature role pathogenesis diseases, work investigating inhibition potential future therapy.
Язык: Английский
Процитировано
149
International Journal of Molecular Sciences, Год журнала: 2022, Номер 24(1), С. 578 - 578
Опубликована: Дек. 29, 2022
Depression is one of the leading mental illnesses worldwide and lowers quality life many. According to WHO, about 5% population suffers from depression. Newer studies report a staggering global prevalence 27.6%, it rising. Professionally, depression belonging affective disorders psychiatric illness, category major depressive disorder (MDD) comprises various diagnoses related persistent disruptive mood disorders. Due this fact, imperative find way assess quantitatively using specific biomarker or panel biomarkers that would be able reflect patients' state effects therapy. Cytokines, hormones, oxidative stress markers, neuropeptides are studied in association with The latest research into inflammatory cytokines shows their relationship etiology causative. There stronger cytokine reactions pathogens stressors If combined other predisposing factors, responses lead prolonged processes, dysregulation axes, stress, pain, changes, anxiety, This review focuses on most recent data as markers concerning roles its pathogenesis, possible use diagnosis management, different levels bodily fluids, similarities animal studies. However, not isolated pathophysiologic mechanisms Their only part whole pathway.
Язык: Английский
Процитировано
141
Nature Reviews Cardiology, Год журнала: 2023, Номер 21(4), С. 219 - 237
Опубликована: Ноя. 3, 2023
Язык: Английский
Процитировано
139