Cellular and Molecular Immunology, Год журнала: 2023, Номер 21(1), С. 95 - 96
Опубликована: Ноя. 7, 2023
Язык: Английский
European Journal of Immunology, Год журнала: 2025, Номер 55(2)
Опубликована: Фев. 1, 2025
Innate immune cells express a plethora of inhibitory receptors, many which recognize molecular patterns. An appropriate balance between signaling via activating and pattern recognition receptors is important for proper response while preventing immunopathology. V-set transmembrane domain containing 1 (VSTM1), also known as signal receptor on leukocytes-1 (SIRL-1), an expressed myeloid cells. VSTM1 can modulate the function cells, by inhibiting reactive oxygen species neutrophil extracellular trap formation. recognizes shared patterns both from endogenous microbial origin, defining it receptor. involved in various pathological conditions, including autoimmune disorders cancer, its restricted expression highlights potential specific therapeutic target. This review summarizes characteristics health disease.
Язык: Английский
Процитировано
0
Arthritis Research & Therapy, Год журнала: 2025, Номер 27(1)
Опубликована: Фев. 3, 2025
Further investigation is required to determine the etiology of systemic lupus erythematosus (SLE). The aim this study assess presence miR-223 within neutrophils in SLE and investigate its impact on expansion Th17 cells. Experiments were performed MRL/lpr mice, which divided into control knockdown (miR-223-) group. We assessed expression mice patients with using RT-PCR, luciferase reporter assay, Elisa, flow cytometry analysis. Signaling pathway, RT-PCR western blot conducted elucidate mechanism by expands Th17. initially identified as a pivotal factor pathogenesis both patients. Subsequently, led significant reduction mice. Moreover, inhibition effectively attenuated recruitment activation SLE. Furthermore, we found rb6-8c5 treatment alleviated symptoms reduce level Finally, elucidated that potentiate induction through thePI3K-AKT pathway mediated during SLE-associated expansion. MiR-223 neutrophil axis contributes PI3K-AKT SLE, could be therapeutic target
Язык: Английский
Процитировано
0
Journal of Dairy Science, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
A healthy uterine environment is essential for establishing and maintaining pregnancy normal embryo development after insemination. In this context, the primary objectives of study were to assess genetic background vaginal discharge score (VDS) traits during voluntary waiting period in Holstein cows identify genomic regions candidate genes influencing postpartum health based on integration phenotypic, genomic, transcriptomic data sets. Genetic parameters 5 VDS defined according lactation stage (VDS1, VDS2, VDS3, VDS4, VDS5) estimated records from 64,241 that calved between 2019 2023 information 2,489 cows. Genome-wide association studies (GWAS) performed aiming associated with traits. Differentially expressed modular obtained through RNA-seq secretion 6 diseased The had low heritability estimates ranging 0.006 ± 0.002 0.081 0.011. Among traits, there relatively strong correlations VDS1 (0-14 DIM) metritis (0.678-0.763) as well VDS3 (29-55 endometritis (0.579-0.628). total 190 harboring 32 significant SNPs identified regulating primiparous significantly enriched pathways involved cytokine-cytokine receptor interaction, MAPK signaling, oxytocin signaling. Based secretions, 2,803 differentially 3,570 identified. Furthermore, 7 GWAS, differential gene expression, weighted co-expression network analysis. VSTM1, IL10RA, FXYD5, C2CD5, CETN4, ALS2CL, PBX1 considered be most promising This provides novel insights results can contribute further refinements selection indexes improving fertility dairy cattle.
Язык: Английский
Процитировано
0
Rheumatology Science and Practice, Год журнала: 2025, Номер 63(1), С. 37 - 45
Опубликована: Март 2, 2025
The study of galectins is provoked by the search for new biomarkers activity, clinical manifestations, and disease outcomes systemic lupus erythematosus (SLE). presented literature review summarizes data on most well-known galectins-1, -3, -9, as well antibodies to galectin-3-binding protein, obtained in culture studies, animal models patients with SLE.
Язык: Английский
Процитировано
0
Seminars in Immunopathology, Год журнала: 2025, Номер 47(1)
Опубликована: Апрель 3, 2025
Galectin-1 (Gal-1), a member of the β-galactoside-binding soluble lectin family, is double-edged sword in immunity. On one hand, it plays crucial role regulating diverse immune cell functions, including apoptosis activated T cells. These processes are key resolving inflammation and preventing autoimmune diseases. other Gal-1 has significant implications cancer, where tumor cells microenvironment (TME) (e.g., tumor-associated fibroblasts, myeloid-derived suppressor cells) secrete to evade surveillance promote cancer growth. Within TME, enhances differentiation tolerogenic dendritic cells, induces effector proliferation regulatory collectively facilitating escape. Therefore, targeting holds potential boost anti-tumor immunity improve efficacy immunotherapy. This review provides insights into intricate regulation, with an emphasis on elucidates how tumors exploit for evasion Furthermore, we discuss as therapeutic target augment current immunotherapies across various types.
Язык: Английский
Процитировано
0
Current Cardiology Reviews, Год журнала: 2024, Номер 20(1)
Опубликована: Янв. 1, 2024
Abstract: Heart failure (HF) is the fastest-growing cardiovascular condition worldwide. The immune system may play a role in development of HF since this associated with elevated pro-inflammatory cytokine levels. life-threatening disease, and there an increasing demand for diagnostic biomarkers, prognostic factors, therapeutic agents that can help treat it. Galectin-1 (Gal-1) prototype galectin lectin family. Multiple signal transduction pathways are regulated by Ras proteins, which act as molecular switch cells. Gal-1 regulates T B cell activation, differentiation, survival. has been linked to inflammation. Activated cells produce through autocrine apoptotic mechanism involving MEK1/ERK p38 MAPK. In system, atherosclerosis facilitated Gal-1. myocardial infarction, hypertension, stroke be caused atherosclerotic plaque. heart hypertrophy decreased cardiac L-type Ca2+ channel activity. Deregulation CaV1.2 pathological suggests possible target anti-hypertrophic therapy. Rat hypertrophic cardiomyocytes express channels simultaneously. It reported diastolic dysfunction (DD) high level subjects led lowest cumulative survival composite endpoint. Incidences HF, DD, serum levels correlated significantly. ejection fraction was negatively CRP concentrations. Based on two different approaches mice humans, identified potential mediator HF.
Язык: Английский
Процитировано
2
Current Opinion in Rheumatology, Год журнала: 2023, Номер 36(2), С. 142 - 147
Опубликована: Ноя. 1, 2023
Purpose of review The exact pathogenic mechanisms rheumatic diseases (RMD) remain largely unknown. Increasing evidence highlights a role neutrophil dysregulation in the development RMD. Recent findings purpose this is to present current overview recent advancements understanding dysfunction Additionally, will discuss strategies for targeting pathways associated with as potential treatments One specific aspect dysregulation, known extracellular traps (NETs), be explored. NETs have been found contribute chronic pulmonary inflammation and fibrosis, well serve DNA scaffolds binding autoantigens, including both citrullinated carbamylated autoantigens. Putative therapies, such 6-gingerol or defibrotide, demonstrated beneficial effects treatment RMD by suppressing formation. Summary advances significantly reinforced crucial pathogenesis A deeper underlying process would aid more precise effective strategies, thus ultimately improving outcomes
Язык: Английский
Процитировано
3
Genomics, Год журнала: 2023, Номер 116(1), С. 110774 - 110774
Опубликована: Дек. 30, 2023
Human VSTM1 (also known as SIRL1) is an inhibitory immune checkpoint receptor involved in leukocyte activation. Identification of the homologous genes other species, such mice and rats, will undoubtedly contribute to functional studies clinical applications. Here, we successfully cloned Vstm1 gene supported by high-throughput sequencing data. However, degenerated a pseudogene mouse genome. Rat mRNA contains complete open reading frame (ORF) 630 nucleotides encoding 209 amino acids. highly expressed bone marrow, especially granulocytes. The expression levels gradually increase with development granulocytes marrow but are downregulated response inflammatory stimuli. does not have immunoreceptor tyrosine-based motif (ITIM), however, it shows conservative function inhibition human VSTM1, both anti-correlated many cytokines, IL-1α TNF-α. In marrow-derived macrophages (BMDMs), either rat or suppressed secretion cytokines LPS stimulation. Further analysis lung cancer microenvironment revealed that mainly myeloid cells, associated tumor metastasis.
Язык: Английский
Процитировано
2
Cellular and Molecular Immunology, Год журнала: 2023, Номер 21(1), С. 95 - 96
Опубликована: Ноя. 7, 2023
Язык: Английский
Процитировано
0