Ultra-Processed Food Addiction: A Research Update

Current Obesity Reports, Год журнала: 2024, Номер 13(2), С. 214 - 223

Опубликована: Май 18, 2024

Detail recent advancements in the science on ultra-processed food (UPF) addiction, focusing estimated prevalence rates and emerging health disparities; progress towards identifying biological underpinnings behavioral mechanisms; implications for weight management.

Язык: Английский

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Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

Periodontology 2000, Год журнала: 2023, Номер unknown

Опубликована: Окт. 16, 2023

Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, require long‐term care. With the exponential increase in NCDs, occurrence of individuals presenting with more one disease is also rapidly rising. “Multimorbidity,” defined presence two or physical mental disorders, now considered epidemic, affecting around 20% adult population. Periodontitis, diabetes, and obesity, all inflammatory diseases, an example multimorbidity highly relevant dental practitioners. Over last three decades, three‐way relationship among has been vastly researched accepted, important contributions by European researchers. The interplay periodontitis, obesity sustained shared biological mechanisms, such systemic inflammation, insulin resistance, metabolic dysfunction, well common lifestyle‐related risk factors. As such, unhealthy lifestyles were found generally inflammation resistance decrease immune function, eventually increasing NCDs onset development multimorbidity. This narrative review evidence supports need for paradigm shift from “single‐disease” “multiple‐disease” framework, characterized integrated multidisciplinary approach, which should include lifestyle modification interventions successfully tackle multimorbid periodontitis (diabetes obesity). A care pathway both medical settings further global health challenge

Язык: Английский

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The impact of the cost of living crisis and food insecurity on food purchasing behaviours and food preparation practices in people living with obesity

Appetite, Год журнала: 2024, Номер 196, С. 107255 - 107255

Опубликована: Фев. 15, 2024

Lower income households are at greater risk of food insecurity and poor diet quality than higher households. In high-income countries, is associated with high levels obesity, in the UK specifically, cost living crisis (i.e., where everyday essentials has increased quicker wages) likely to have exacerbated existing dietary inequalities. There currently a lack understanding impact current on purchasing preparation practices people obesity (PLWO) insecurity, however this knowledge critical order develop effective prevention treatment approaches reducing Using an online survey (N = 583) adults residing England or Scotland body mass index (BMI) ≥30 kg/m2, participants self-reported quality, perceived crisis, their responses terms behaviours practices. Regression analyses found that adversely impacted by reported experiencing insecurity. Additionally, was use specific budgeting, supermarket offers) energy-saving appliances, resourcefulness). Exploratory indicated who used budgeting had low whereas meal planning quality. These findings highlight fragility budgets coping strategies PLWO during crisis. Policy measures interventions urgently needed address underlying economic factors contributing improve access affordability healthier foods for all.

Язык: Английский

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Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy

Journal of Pharmacy & Pharmaceutical Sciences, Год журнала: 2024, Номер 27

Опубликована: Апрель 19, 2024

Unhealthy sources of fats, ultra-processed foods with added sugars, and a sedentary lifestyle make humans more susceptible to developing overweight obesity. While lipids constitute an integral component the organism, excessive abnormal lipid accumulation that exceeds storage capacity droplets disrupts intracellular composition fatty acids results in release deleterious species, thereby giving rise pathological state termed lipotoxicity. This condition induces endoplasmic reticulum stress, mitochondrial dysfunction, inflammatory responses, cell death. Recent advances omics technologies analytical methodologies clinical research have provided novel insights into mechanisms lipotoxicity, including gut dysbiosis, epigenetic epitranscriptomic modifications, dysfunction droplets, post-translational altered membrane composition. In this review, we discuss recent knowledge on underlying development lipotoxicity lipotoxic cardiometabolic disease obesity, particular focus diabetic cardiomyopathy.

Язык: Английский

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The global and regional burden of diabetic peripheral neuropathy

Nature Reviews Neurology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Язык: Английский

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An assessment of compliance with proposed regulations to restrict on-package marketing of packaged foods to improve nutrition in South Africa

BMC Nutrition, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 21, 2025

Ultra-processed products (UPPs), high in sugar, fat and sodium, contribute to increasing burdens of obesity non-communicable diseases South Africa (SA). Increased consumption acceptability UPPs is driven, part by aggressive marketing. Front package labelling laws, particularly warning labels (WLs) coupled with marketing restrictions, have been recommended improve consumer awareness unhealthy products, incentivise reformulation underpin other interventions. The SA government published a draft regulation introduce WLs restrict marketing, called R3337. This study aims analyse on-package create baseline evaluate compliance the proposed an analysis dataset 6768 packaged food collected as pictures four major grocery stores Cape Town, between March July 2019. A codebook was developed based on R337. used identify assess child-directed (CDM) health claims potentially subject front-of-package WLs. Food packages their nutritional information were coded analyzed determine whether product would be required carry WL included regulated majority (80.16%) require under R3337 due levels or saturated fat. CDM prevalent, 59.26% displaying some form primarily animated characters depictions children. Health also common, 83% occurring products. Using system could effectively target common forms given prevalence likely Such interventions may improving diets reducing UPP consumption. Some are not we recommend expanding include these. provides which should for future research when it implemented.

Язык: Английский

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Current Therapeutic Landscape for Metabolic Dysfunction-Associated Steatohepatitis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1778 - 1778

Опубликована: Фев. 19, 2025

In recent years, “metabolic dysfunction-associated steatotic liver disease” (MASLD) has been proposed to better connect disease metabolic dysfunction, which is the most common chronic worldwide. MASLD affects more than 30% of individuals globally, and it diagnosed by combination hepatic steatosis obesity, type 2 diabetes, or two risk factors. begins with buildup extra fat, often greater 5%, within liver, causing hepatocytes become stressed. This can proceed a severe form, steatohepatitis (MASH), in 20–30% people, where inflammation causes tissue fibrosis, limits blood flow over time. As fibrosis worsens, MASH may lead cirrhosis, failure, even cancer. While pathophysiology not fully known, current “multiple-hits” concept proposes that dietary lifestyle factors, genetic epigenetic factors contribute elevated oxidative stress inflammation, fibrosis. review article provides an overview pathogenesis evaluates existing therapies as well pharmacological drugs are currently being studied clinical trials for MASH.

Язык: Английский

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Usage of Glucagon-Like Peptide-1 for Obesity in Children; Updated Review of Clinicaltrials.gov

Journal of Multidisciplinary Healthcare, Год журнала: 2023, Номер Volume 16, С. 2179 - 2187

Опубликована: Июль 1, 2023

Background: Obesity in both adults and children is a primary health concern that can lead to many complications at young age, including insulin resistance, type 2 diabetes, other diseases. Glucagon-like peptide-1 receptor agonists (GLP-1) are drugs utilized treat but they also approved as an adjunct low-calorie diet reduce body weight enhance the metabolic profile readings for diabetic non-diabetic patients. However, their efficacy safety have not been extensively examined. Aim: To identify glucagon-like medications obesity pediatric participants (aged up 17 years old). Methods: Analysis of all clinical trials registered on ClinicalTrials.gov using GLP-1 treatment children. Results: As January 26th, 2023, 10,828 were found. The search included childhood GLP-1. number use limited. final analyzed was 19. has shown result effective management gain among Conclusion: Exenatide, semaglutide, liraglutide only used pharmacotherapy option. It studied circumstances eg, with severe obesity, PCOS, hypothalamic glucose tolerance, complementary alongside behavior-lifestyle change surgery obesity. Keywords: GLP-1, trials, exenatide,

Язык: Английский

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Measuring Motivations to Eat Palatable Foods: Adaptation and Psychometric Properties of the Italian Version of the Palatable Eating Motives Scale (PEMS-IT)

Healthcare, Год журнала: 2024, Номер 12(5), С. 574 - 574

Опубликована: Фев. 29, 2024

Background: Gaining knowledge of the various reasons behind people’s consumption highly processed foods has potential to enhance obesity prevention initiatives and open avenues tailor treatment approaches for binge eating at a more personalized level. This contribution aimed test psychometric properties factor structure Palatable Eating Motives Scale (PEMS-IT) in community sample Italian adults. Methods: A confirmatory analysis was performed version PEMS on total 616 respondents. Furthermore, reliability convergent validity tool were evaluated. Results: The confirmed four-factor PEMS-IT [(YBχ2 (164) = 537.901; p < 0.001, CFI 0.918, RMSEA 0.072; 90%CI [0.065–0.078]; p(RMSEA 0.05) SRMR 0.080] satisfactory its subscales (Cronbach’s α: 0.745–0.917). Positive correlations also found with food addiction binge-eating symptoms, compulsive behavior, uncontrolled emotional eating. Conclusions: appears be an instrument promising applications clinical settings. However, it some limitations, future studies could focus improving semantic content elements increase overall utility precision instrument.

Язык: Английский

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Relation of Minimally Processed Foods and Ultra-Processed Foods with the Mediterranean Diet Score, Time-Related Meal Patterns and Waist Circumference: Results from a Cross-Sectional Study in University Students

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(4), С. 2806 - 2806

Опубликована: Фев. 4, 2023

Ultra-processed foods are associated with chronic diseases, cardiometabolic factors and obesity. According to the NOVA system, classified into four categories (from 1 = unprocessed 4 ultra-processed foods). The purpose of present study was assess consumption minimally processed (MPF) (UPF) in university students their relationship obesity, Mediterranean diet adherence meal patterns. In total, 346 (269 women) University Peloponnese participated. A food frequency questionnaire used, MedDietScore calculated. % energy contribution MPF UPF identification patterns performed via principal component analysis. Both multivariate regression Spearman’s correlations were used measure association UPF/MPF anthropometric indices (body mass index, BMI waist circumference, WC), early/late provided 40.7 ± 13.6% 44.3 11.9% (mean standard deviation) intake, respectively. multi-adjusted linear models (% energy) positively WC men but it not related (total sample, men, women). negatively (Spearman rho −0.214, p < 0.001) an “early eating” pattern −0.120, 0.029) a “late 0.190, 0.001). 0.309, 0.240, conclusion, male students. Nutritional sociodemographic correlates consumption, such as low having serve basis better understand consumption-central obesity relation young adults should be considered nutrition education programs for adults.

Язык: Английский

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