Genes,
Год журнала:
2024,
Номер
15(10), С. 1296 - 1296
Опубликована: Окт. 2, 2024
After
myocardial
infarction
(MI),
adverse
left
ventricular
(LV)
remodeling
may
occur.
This
is
followed
by
LV
hypertrophy
and
eventually
heart
failure.
The
process
complex
goes
through
multiple
phases.
aim
of
this
study
was
to
investigate
the
expression
Frontiers in Cardiovascular Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 26, 2024
Cardiovascular
diseases
include
myocardial
infarction,
a
high
mortality
disease.
Myocardial
infarction
patients
are
becoming
younger,
typically
defined
as
under
45
years
of
age.
This
study
analyzes
the
relevant
papers
on
in
youth
Web
Science
Core
Collection
(WoSCC)
between
1980
and
2023.
Frontiers in Cardiovascular Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Дек. 18, 2024
Despite
improvements
in
clinical
outcomes
of
acute
myocardial
infarction
(AMI),
mortality
rates
remain
high,
indicating
the
need
for
further
understanding
pathogenesis
and
developing
more
effective
cardiac
protection
strategies.
Extracellular
vesicles
(EVs)
carry
proteins
noncoding
RNAs
(ncRNAs)
derived
from
different
cell
populations,
mainly
including
cardiomyocytes,
endothelial
cells,
progenitor
cardiosphere-derived
immune
fibroblasts
telocytes
have
vital
roles
under
both
physiological
pathological
process
such
as
(MI).
The
content
EVs
can
also
indicate
status
their
parental
cells
serve
a
biomarker
monitoring
risk
injury.
Examining
these
offer
fresh
perspectives
on
development
MI
assist
creating
innovative
treatments.
Additionally,
mesenchymal
stem
(MSCs)
(MSC-EVs)
been
shown
to
significant
potential
regeneration.
In
this
review,
we
will
discuss
current
role
communication,
with
focus
various
MSCs
uses
therapies
after
MI.
There
has
been
a
gradual
increase
in
the
occurrence
of
cardiovascular
and
cerebrovascular
ischemic
diseases,
particularly
as
comorbidities.
Yet,
mechanisms
underlying
these
diseases
remain
unclear.
Ferroptosis
emerged
potential
contributor
to
cardio-cerebral
processes.
Therefore,
this
study
investigated
shared
biological
between
two
processes,
well
role
ferroptosis
genes
damage,
by
constructing
co-expression
modules
for
myocardial
ischemia
(MI)
stroke
(IS)
network
protein-protein
interactions,
mRNA-miRNA,
mRNA-transcription
factors
(TFs),
mRNA-RNA-binding
proteins
(RBPs),
mRNA-drug
interactions.The
identified
seven
key
genes,
specifically
ACSL1,
TLR4,
ADIPOR1,
G0S2,
PDK4,
HP,
PTGS2,
subjected
them
functional
enrichment
analysis
during
ischemia.
The
predicted
miRNAs
were
found
interact
with
35
hub
interactions
observed
11
30
TF
transcription
factors.
Additionally,
10
RBPs
corresponding
16
163
molecular
compounds
identified.
This
also
clarified
levels
immune
infiltration
MI
IS
different
subtypes.
Finally,
we
four
including
using
diagnostic
model
constructed
Least
Absolute
Shrinkage
Selection
Operator
(LASSO)
regression
analysis;
HP
shown
have
value
co-pathogenesis
cerebral
both
validation
test
data
RT-qPCR
assay.To
best
our
knowledge,
is
first
utilize
multiple
algorithms
comprehensively
analyze
processes
from
various
perspectives.
proven
valuable
offering
insights
investigation
injury
pathways
injuries.
may
serve
markers
diseases.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
Abstract
Objective
Cardiovascular
disorders
constitute
a
substantial
threat
to
global
human
health
and
safety.
Of
note,
acute
myocardial
infarction
(AMI),
being
grave
cardiovascular
disorder,
has
garnered
considerable
attention
owing
its
elevated
prevalence,
mortality
broad
demographic
distribution.
It
is
well
established
that
hypoxia-induced
apoptosis
significantly
contributes
towards
the
onset
progression
of
AMI;
however,
several
aspects
regarding
biological
indicators
molecular
mechanisms
AMI
remain
elusive.
Method
This
investigation
utilized
Gene
Expression
Comprehensive
(GEO)
database
perform
comprehensive
analysis
pivotal
genes
employing
techniques
like
differential
analysis,
Venn
weighted
correlation
network
(WGCNA).
Subsequently,
between
key
factors
was
scrutinized,
potential
causal
link
these
outcome
probed
via
Mendelian
randomization
(MR).
Additionally,
real-time
quantitative
polymerase
chain
reaction
(RT-qPCR)
lentivirus
transfection
experiments
were
executed,
miRNA-mRNA
networks
constructed
utilizing
miRBase
databases,
three-dimensional
structures
predicted
with
aid
RNAfold
Vfold3D
drug
sensitivity
conducted
using
RNAactDrug
databases.
Result
Following
classification,
WGCNA
clustering,
Wien
screening
two
distinctly
expressed
intimately
linked
-
PTEN
BCL2L11
successfully
identified.
The
outcomes
RT-qPCR
infection
corroborated
expression
pattern
conformed
our
prior
findings.
unveiled
robust
relationship
single
nucleotide
polymorphisms
(SNPs)
AMI.
Lastly,
through
susceptibility
it
discerned
Ispinesib
Mesylate,
Bleomycin
(50
uM)/miR-141-3p/BCL2L11
axis
could
potentially
serve
as
efficacious
therapeutic
or
preventive
strategies
against
Conclusion
In
this
study,
we
introduced
novel
concepts
Mesylate
axis,
offering
fresh
perspective
on
apoptotic
mechanism
in
MEDIA STATISTIKA,
Год журнала:
2024,
Номер
17(1), С. 69 - 80
Опубликована: Окт. 13, 2024
One
disease
that
can
cause
death
is
Acute
Myocardial
Infarction
(AMI).
AMI,
also
known
as
a
heart
attack,
condition
causes
permanent
damage
to
muscle
tissue
due
prolonged
ischemia
or
lack
of
blood
flow
occurs
blockage
the
epicardial
coronary
arteries
and
results
in
clots
limiting
supply
myocardium.
During
years
young
AMI
patients
are
increasing.
ways
diagnose
early
providing
information
biomarkers
related
this
by
implementing
bioinformatics
data
analysis.
The
research
was
conducted
look
at
genomic
profile
suffering
from
based
on
without
recurrent
events
normal
control,
using
XGBoost
method,
its
scalability
efficiency.
Based
grid
search
tuning
hyperparameters,
method
gives
classification
accuracy
88.89%,
AUC
90
kappa
0.7805.
These
indicate
classify
well.
This
has
identified
three
genes
contribute
most
classifying
patients,
namely
calponin
2,
ribosomal
protein
S11
myotropin.
heatmap
visualization,
obtained
class
markers
events.
