Putting Nose into Reproduction: Influence of Nasal and Reproductive Odourant Signaling on Male Reproduction

Molecular Reproduction and Development, Год журнала: 2025, Номер 92(1)

Опубликована: Янв. 1, 2025

ABSTRACT Odourant receptors (ORs) are not restricted only to the nose, but also occur in many other organs and tissues, including reproductive system. In fact, ORs most heavily expressed testis than any extra‐nasal tissue. Accumulating evidence suggests that olfactory systems both structurally functionally linked these interconnections can influence various aspects of reproduction. this article, we first review our current understanding then collate accumulated on presence male system sperm cells. We investigate potential role female tract odourants chemotaxis selection. Finally, since existing especially for odor sensing capability its physiological function controversial, reasons controversy propose some ways resolve debate. Collectively, conclude odourant signaling may play an important, although currently largely unclear key processes directly related fertility. However, lack holistic functional significance pathways system, more empirical research is warranted.

Язык: Английский

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Genetic incompatibility of the reproductive partners: an evolutionary perspective on infertility

Human Reproduction, Год журнала: 2021, Номер 36(12), С. 3028 - 3035

Опубликована: Сен. 13, 2021

ABSTRACT In natural fertilisation, the female reproductive tract allows only a strictly selected sperm subpopulation to proceed in vicinity of an unfertilised oocyte. Female-mediated selection (also known as cryptic choice (CFC)) is far from random process, which frequently biases paternity towards particular males over others. Earlier studies have shown that CFC ubiquitous phenomenon animal kingdom and often promotes assortative fertilisation between genetically compatible mates. Here, I demonstrate for genetic compatibility likely also occurs humans mediated by complex network interacting male genes. show relative contribution (i.e. male–female interaction effect) success generally high outweighs effects individual females. Together, these facts indicate that, along with male- female-dependent pathological factors, failure can result gamete-level incompatibility partners. Therefore, argue deeper understanding evolutionary mechanisms pave way more inclusive view infertility open novel possibilities development personalised diagnostics treatments.

Язык: Английский

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Cryptic female choice within individual males – A neglected component of the postmating sexual selection?

Journal of Evolutionary Biology, Год журнала: 2022, Номер 35(11), С. 1407 - 1413

Опубликована: Авг. 21, 2022

Cryptic female choice (CFC) is commonly assumed to act only in polyandrous mating systems, which allows females bias fertilization towards the sperm of particular males. However, accumulated evidence has demonstrated that show significant phenotypic and genotypic variation also within single ejaculates, have important consequences for offspring phenotype fitness. Here, I argue these neglected sources intra-male often allow CFC individual males facilitate genetically compatible (or otherwise preferred) haplotypes. In this article, explain prerequisites within-male CFC, criteria demonstrating it summarize emerging selection process. Then, evaluate prevalence review its potential evolutionary consequences. The aim article broaden current definition by all both internally externally fertilizing species. Incorporation concept into models sexual may provide novel insights deeper understanding selective factors driving evolution systems reproductive proteins. Finally, haplotypes increase our non-Mendelian inheritance.

Язык: Английский

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Effect of MHC and inbreeding on disassortative reproduction: A data revisit, extension and inclusion of fertilization in sand lizards

Ecology and Evolution, Год журнала: 2023, Номер 13(3)

Опубликована: Март 1, 2023

Abstract The harmful effects of close inbreeding have been recognized for centuries and, with the rise Mendelian genetics, was realized to be an effect homozygosis. This historical background led great interest in ways quantify inbreeding, its depression on phenotype and flow‐on mate choice other aspects behavioral ecology. mechanisms cues used avoid are varied include major histocompatibility complex (MHC) molecules peptides they transport as predictors degree genetic relatedness. Here, we revisit complement data from a Swedish population sand lizards ( Lacerta agilis ) showing signs assess relatedness pair formation wild. Parental pairs were less similar at MHC than expected under random mating but mated respect microsatellite clustered groups RFLP bands no partner preference observed cluster genotype. Male band patterns unrelated their fertilization success clutches selected analysis basis mixed paternity. Thus, our suggest that plays role pre‐copulatory, not post‐copulatory association, suggesting is driver bias gamete recognition lizards.

Язык: Английский

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Applying an evolutionary perspective to assisted reproductive technologies

PNAS Nexus, Год журнала: 2024, Номер 3(12)

Опубликована: Ноя. 28, 2024

Abstract Assisted reproductive technologies (ART) are commonly used to address human infertility and boost livestock production. During ART, procedures such as in vitro fertilization, artificial insemination, intracytoplasmic sperm injection introduce gametes embryos unnatural potentially stressful conditions that can influence offspring health, often via epigenetic effects. In this perspective we summarize these key risks of ART for embryonic longer-term fitness, emphasizing the need experimental research on animal models determine causal links between fitness across multiple generations. We also highlight how bypass a range naturally sexually selected mechanisms occur female tract and/or secretions ultimately which fertilize their eggs. further argue curtailment female-modulated selection may have important consequences ART-conceived offspring. encourage development methods better mimic natural processes embrace fundamental principles sexual selection. Ultimately, aim is dialogue fields evolutionary biology applied areas reproduction.

Язык: Английский

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The Badgers of Wytham Woods

Oxford University Press eBooks, Год журнала: 2022, Номер unknown

Опубликована: Ноя. 1, 2022

Abstract The Wytham badger study was begun in earnest by Hans Kruuk 1972, with David Macdonald his graduate student, and turn Chris Newman, David’s student. Fifty years later they have documented the genealogy, births, deaths, ‘marriages’ of over 1900 individuals. book is a journey from particular to general, developing themes model species that grows authors’ approach Badgers Woods: A Model for Behaviour, Ecology, Evolution. This accessible monograph engages 50 primary research woven around badgers Woods (Oxford, UK), covering topics as diverse life history strategy, climate change biology, genetics, communication, senescence, immunology, endocrinology, epidemiology. begins aspects individual behaviour, starting birth, early development, then recruitment youngsters into their social groups. In quest understand society its adaptive significance, following chapters describe networks, dynamics within those ultimately evaluate pros and, importantly, cons group living. account turns paradoxical relationships between adjoining groups, offers an ecological framework which interpret this sociology, explaining how living can evolve facultatively benefit equally adapted much less gregariously under other circumstances. Next story population levels analysis, exploring demography, impacts density, trade-offs (including pace theory), extrinsic factors such weather. population-level sequence leads diseases, specifically, role reservoir bovine tuberculosis, before moving yet different level—molecular. continues genetic selection thence adding bookend opening birth. concluding chapter sets variation at two levels, intra-specific inter-specific, culminates exploration theme throughout book: emergent outcome ecology environmental conditions experience, framed phylogeny Mustelidae more broadly, mammalian evolution.

Язык: Английский

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Female‐induced selective modification of sperm protein SUMOylation—potential mechanistic insights into the non‐random fertilization in humans

Journal of Evolutionary Biology, Год журнала: 2022, Номер 35(2), С. 254 - 264

Опубликована: Янв. 9, 2022

Abstract In many species, mate choice continues after the mating via female‐ or egg‐derived biochemical factors that induce selective changes in sperm pre‐fertilization physiology and behaviour. Recent studies have indicated gamete‐mediated likely occurs also humans, but mechanistic basis of process has remained virtually unexplored. Here, we investigated whether female‐induced modifications protein SUMOylation (post‐translational modification proteome) could serve as a novel mechanism for humans. We treated ten males with oocyte‐surrounding bioactive liquid (follicular fluid) five females motility, viability global status all ( n = 50) these male–female combinations (full‐factorial design). All measured traits were affected by combinations, was negatively associated motility. Furthermore, our results indicate is selective, potentially allowing to increase motility some males, whereas decreasing it others. Consequently, findings suggest follicular fluid may non‐randomly modify structure function proteome this way facilitate humans possibly other species. However, due relatively low number female subjects their potential infertility problems, should be replicated larger subset fully fertile women.

Язык: Английский

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Metabolic syndrome and male fertility disorders: Is there a causal link?

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2021, Номер 22(4), С. 1057 - 1071

Опубликована: Май 26, 2021

Язык: Английский

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Female reed warblers in social pairs with low MHC dissimilarity achieve higher MHC compatibility through random extra-pair matings

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Апрель 18, 2023

Abstract Major Histocompatibility Complex (MHC) polymorphism is maintained by balancing selection through host-pathogen interactions and mate choice. MHC-based choice has been proposed across a wide range of vertebrates. However, the likelihood its existence in songbirds questioned because their poorly developed olfactory sense, which trait considered crucial pre-copulatory to determine both own MHC putative partners. In this study, we show that female reed warblers, Acrocephalus scirpaceus , with extra-pair young nests have lower class I (MHC-I) dissimilarity social than females without nests. We also MHC-I successfully siring males not different from either other territories surrounding nest ( i.e. males) or pairs Taken together observation mating warblers common, argue these results support scenario where more likely lead successful fertilisation when there high similarity between her male. Furthermore, as our data suggest at random can result higher does require any active for dissimilar drive pattern.

Язык: Английский

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Structural dissimilarity of partners' immune genes increases sperm viability in women's reproductive tract

Journal of Evolutionary Biology, Год журнала: 2021, Номер 34(7), С. 1125 - 1132

Опубликована: Май 31, 2021

Abstract Human leucocyte antigen (HLA) genes appear to mediate pre‐ and post‐copulatory mate choice towards HLA‐dissimilar (‘compatible’) partners. However, since genetically distinct alleles often have similar immunogenic properties, genetic dissimilarity is not necessarily an accurate predictor of the functional compatibility HLA and, hence, may reflect partners' true compatibility. Furthermore, it has remained unclear whether other immune system could also play a role in male–female We studied immunoglobulin binding regions (eplets) molecules structural partners affect their gamete‐level exposed sperm multiple men follicular fluid or cervical mucus women tested viability these reproductive secretions was influenced by eplet between found that positively affects fluid, whereas enhanced mucus. Together, findings indicate characteristics both immunoglobulins facilitate cryptic female immunologically compatible Our results, thus, wider immunological basis than traditionally been assumed. Relative contribution different immunogenetic factors overall needs be clarified future studies.

Язык: Английский

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