Scientific Reports, Год журнала: 2019, Номер 9(1)

Опубликована: Сен. 9, 2019

Abstract The prevalence of many chronic diseases has increased over the last decades. It been postulated that dysbiosis driven by environmental factors such as antibiotic use is shifting microbiome in ways increase inflammation and onset disease. Dysbiosis can be defined through loss or gain bacteria either promote health disease, respectively. Here we multiple independent datasets to determine nature for a cluster includes urinary stone disease (USD), obesity, diabetes, cardiovascular kidney which often exist co-morbidities. For all states, individuals exhibited statistically significant association with antibiotics year compared healthy counterparts. There was also between gut microbiota composition. Furthermore, each state associated microbial diversity gut. Three genera, Bacteroides, Prevotella , Ruminococcus were most common dysbiotic taxa terms being enriched depleted populations part operational taxonomic units (OTUs) within these genera. Results cross-sectional analysis suggest antibiotic-driven may risk However, longitudinal studies are needed confirm causative effect risk.

Язык: Английский