Microbiota and maintenance of skin barrier function

Science, Год журнала: 2022, Номер 376(6596), С. 940 - 945

Опубликована: Май 26, 2022

Human skin forms a protective barrier against the external environment and is our first line of defense toxic, solar, pathogenic insults. Our also defines outward appearance, protects internal tissues organs, acts as sensory interface, prevents dehydration. Crucial to skin's function colonizing microbiota, which provides protection pathogens, tunes immune responses, fortifies epithelium. Here we highlight recent advances in understanding how microbiota mediates multiple facets function. We discuss insights into pathological host-microbiota interactions implications for disorders distant organs. Finally, examine microbiota-based mechanisms can be targeted prevent or manage impaired wound healing.

Язык: Английский

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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Язык: Английский

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Metabolites as signalling molecules

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 24(5), С. 355 - 374

Опубликована: Янв. 12, 2023

Язык: Английский

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Microbiota-mediated colonization resistance: mechanisms and regulation

Nature Reviews Microbiology, Год журнала: 2022, Номер 21(6), С. 347 - 360

Опубликована: Дек. 20, 2022

Язык: Английский

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Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Апрель 29, 2022

The global coronavirus disease 2019 (COVID-19) pandemic is currently ongoing. It caused by severe acute respiratory syndrome 2 (SARS-CoV-2). A high proportion of COVID-19 patients exhibit gastrointestinal manifestations such as diarrhea, nausea, or vomiting. Moreover, the and tracts are primary habitats human microbiota targets for SARS-CoV-2 infection they express angiotensin-converting enzyme-2 (ACE2) transmembrane protease serine (TMPRSS2) at levels. There accumulating evidence that significantly altered in with post-acute (PACS). Microbiota powerful immunomodulatory factors various diseases, diabetes, obesity, cancers, ulcerative colitis, Crohn's disease, certain viral infections. In present review, we explore associations between host terms their clinical relevance. Microbiota-derived metabolites components main mediators microbiota-host interactions influence immunity. Hence, discuss potential mechanisms which microbiota-derived modulate immune responses to infection. Finally, review a variety possible microbiota-based prophylaxes therapies PACS, including fecal transplantation (FMT), probiotics, prebiotics, metabolites, engineered symbiotic bacteria. This treatment strategy could mitigate virus-induced inflammation.

Язык: Английский

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The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 4494 - 4494

Опубликована: Апрель 19, 2022

An emerging body of literature demonstrates differences in the gut microbiome (GMB) patients with major depressive disorder (MDD) compared to healthy controls (HC), as well potential benefits prebiotic, probiotic, and synbiotic treatment. We conducted a systematic review 24 observational studies (n = 2817), 19 interventional trials 1119). assessed alpha diversity, beta taxa abundance changes MDD relative HC, effect prebiotics, probiotics, synbiotics on symptoms individuals clinical or subclinical depression. observed no significant diversity but difference between HC. There were fluctuations specific Probiotic synbiotic, not treatment showed modest benefit reducing over four nine weeks. The GMB profiles differ significantly from further are needed elucidate probiotic treatments antidepressants longer follow-up before these therapies implemented into practice.

Язык: Английский

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Probiotic‐Inspired Nanomedicine Restores Intestinal Homeostasis in Colitis by Regulating Redox Balance, Immune Responses, and the Gut Microbiome

Advanced Materials, Год журнала: 2022, Номер 35(3)

Опубликована: Ноя. 7, 2022

Microbiota-based therapeutics offer innovative strategies to treat inflammatory bowel diseases (IBDs). However, the poor clinical outcome so far and limited flexibility of bacterial approach call for improvement. Inspired by health benefits probiotics in alleviating symptoms diseases, bioartificial are designed restore intestinal microenvironment colitis regulating redox balance, immune responses, gut microbiome. The probiotic comprises two components: an E. coli Nissle 1917-derived membrane (EM) as surface biodegradable diselenide-bridged mesoporous silica nanoparticles (SeM) core. When orally administered, probiotic-inspired nanomedicine (SeM@EM) adheres strongly mucus layer restored balance regulation homeostasis a murine model acute induced dextran sodium sulfate. In addition, respective properties EM SeM synergistically alter microbiome favorable state increasing diversity shifting profile anti-inflammatory phenotype. This work suggests safe effective that can IBDs therapy.

Язык: Английский

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Pain-resolving immune mechanisms in neuropathic pain

Nature Reviews Neurology, Год журнала: 2023, Номер unknown

Опубликована: Март 1, 2023

Язык: Английский

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Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer

Advanced Science, Год журнала: 2023, Номер 10(23)

Опубликована: Июнь 1, 2023

Colorectal cancer (CRC) is the most common of digestive system with high mortality and morbidity rates. Gut microbiota found in intestines, especially colorectum, has structured crosstalk interactions host that affect several physiological processes. The gut include CRC-promoting bacterial species, such as Fusobacterium nucleatum, Escherichia coli, Bacteroides fragilis, CRC-protecting Clostridium butyricum, Streptococcus thermophilus, Lacticaseibacillus paracasei, which along other microorganisms, viruses fungi, play critical roles development CRC. Different features are identified patients early-onset CRC, combined different patterns between fecal intratumoral microbiota. may be beneficial diagnosis treatment CRC; some bacteria serve biomarkers while others regulators chemotherapy immunotherapy. Furthermore, metabolites produced by essential CRC cells. Harmful primary bile acids short-chain fatty acids, whereas others, including ursodeoxycholic acid butyrate, impede tumor progression. This review focuses on its metabolites, their potential development, diagnosis,

Язык: Английский

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Alternative therapeutic strategies to treat antibiotic-resistant pathogens

Nature Reviews Microbiology, Год журнала: 2023, Номер 22(5), С. 262 - 275

Опубликована: Дек. 11, 2023

Язык: Английский

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