Chemical Society Reviews,
Год журнала:
2021,
Номер
50(14), С. 8003 - 8049
Опубликована: Янв. 1, 2021
Technological
developments
enable
the
discovery
of
novel
enzymes,
advancement
enzyme
cascade
designs
and
pathway
engineering,
moving
biocatalysis
into
an
era
technology
integration,
intelligent
manufacturing
enzymatic
total
synthesis.
Drugs and Drug Candidates,
Год журнала:
2024,
Номер
3(1), С. 184 - 207
Опубликована: Фев. 19, 2024
For
thousands
of
years,
nature
has
been
a
source
medical
substances,
and
an
astounding
numeral
contemporary
remedies
have
identified
from
natural
origins.
Plants
long
used
as
folk
herbal
medicines
to
treat
various
disorders,
their
different
products
inspired
the
design,
discovery,
development
new
drugs.
With
invention
recent
molecular
targets
based
on
proteins,
there
is
growing
need
for
fresh
chemical
diversification
in
screening.
Natural
will
play
vital
part
supplying
this
via
continuous
exploration
global
biodiversity,
majority
which
remains
unexplored.
Even
though
drug
discovery
medicinal
plants
important
novel
therapeutic
leads,
hurdles
exist,
including
identifying
executing
suitable
high-throughput
screening
bioassays,
scaling
up
supply
bioactive
molecules,
acquiring
plant
materials.
Investigating
these
resources
takes
multi-disciplinary,
nationwide,
partnerships
synthesis,
techniques.
This
review
article
discusses
current
advancements
future
approaches
discovering
items
such
health-
wellness-promoting
remedies.
It
also
summarizes
strategies
unify
use
plant-derived
worldwide
support
discoveries
derived
sources.
Chemical Reviews,
Год журнала:
2020,
Номер
121(6), С. 3495 - 3560
Опубликована: Ноя. 9, 2020
The
crisis
of
antibiotic
resistance
necessitates
creative
and
innovative
approaches,
from
chemical
identification
analysis
to
the
assessment
bioactivity.
Plant
natural
products
(NPs)
represent
a
promising
source
antibacterial
lead
compounds
that
could
help
fill
drug
discovery
pipeline
in
response
growing
crisis.
major
strength
plant
NPs
lies
their
rich
unique
chemodiversity,
worldwide
distribution
ease
access,
various
modes
action,
proven
clinical
effectiveness
extracts
which
they
are
isolated.
While
many
studies
have
tried
summarize
with
activities,
comprehensive
review
rigorous
selection
criteria
has
never
been
performed.
In
this
work,
literature
2012
2019
was
systematically
reviewed
highlight
plant-derived
activity
by
focusing
on
growth
inhibitory
activity.
A
total
459
included
Review,
50.8%
phenolic
derivatives,
26.6%
terpenoids,
5.7%
alkaloids,
17%
classified
as
other
metabolites.
183
is
further
discussed
regarding
activity,
biosynthesis,
structure-activity
relationship,
mechanism
potential
antibiotics.
Emerging
trends
field
plants
also
discussed.
This
Review
brings
forefront
key
findings
for
consideration
future
development
efforts.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Дек. 11, 2020
Synthetic
biology
will
transform
how
we
grow
food,
what
eat,
and
where
source
materials
medicines.
Here
I
have
selected
six
products
that
are
now
on
the
market,
highlighting
underlying
technologies
projecting
forward
to
future
can
be
expected
over
next
ten
years.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Март 2, 2021
Abstract
Synthetic
biology
holds
great
promise
for
addressing
global
needs.
However,
most
current
developments
are
not
immediately
translatable
to
‘outside-the-lab’
scenarios
that
differ
from
controlled
laboratory
settings.
Challenges
include
enabling
long-term
storage
stability
as
well
operating
in
resource-limited
and
off-the-grid
using
autonomous
function.
Here
we
analyze
recent
advances
developing
synthetic
biological
platforms
outside-the-lab
with
a
focus
on
three
major
application
spaces:
bioproduction,
biosensing,
closed-loop
therapeutic
probiotic
delivery.
Across
the
Perspective,
highlight
advances,
areas
further
development,
possibilities
future
applications,
needs
innovation
at
interface
of
other
disciplines.
Synthetic and Systems Biotechnology,
Год журнала:
2022,
Номер
7(1), С. 602 - 620
Опубликована: Фев. 2, 2022
UDP-Glycosyltransferases
(UGTs)
catalyze
the
transfer
of
nucleotide-activated
sugars
to
specific
acceptors,
among
which
GT1
family
enzymes
are
well-known
for
their
function
in
biosynthesis
natural
product
glycosides.
Elucidating
GT
represents
necessary
step
metabolic
engineering
aglycone
glycosylation
produce
drug
leads,
cosmetics,
nutrients
and
sweeteners.
In
this
review,
we
systematically
summarize
phylogenetic
distribution
catalytic
diversity
plant
GTs.
We
also
discuss
recent
progress
identification
novel
candidates
synthesis
products
(PNPs)
using
multi-omics
technology
deep
learning
predicted
models.
highlight
advances
rational
design
directed
evolution
strategies
new
or
improved
functions.
Finally,
cover
breakthroughs
application
GTs
microbial
some
representative
glycosylated
PNPs,
including
flavonoid
glycosides
(fisetin
3-
