Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology,
Год журнала:
2023,
Номер
14(1)
Опубликована: Янв. 18, 2023
Growth-promoting
antibiotics
have
been
banned
by
law
in
the
livestock
and
poultry
breeding
industry
many
countries.
Various
alternatives
to
investigated
for
using
livestock.
Epimedium
(EM)
is
an
herb
rich
flavonoids
that
has
beneficial
effects
on
animals.
Therefore,
this
study
was
planned
explore
potential
of
EM
as
a
new
alternative
antibiotic
product
animal
feed.A
total
720
1-day-old
male
broilers
(Arbor
Acres
Plus)
were
randomly
divided
into
six
groups
fed
basal
diet
(normal
control;
NC),
supplemented
with
(75
mg/kg
chlortetracycline;
CTC),
100,
200,
400
or
800
extract
6
weeks
(EM100,
EM200,
EM400
EM800
groups).
The
growth
performance
at
3
measured.
Serum,
intestinal
tissue
feces
collected
assay
antioxidant
indexes,
permeability,
lactic
acid
short-chain
fatty
acids
(SCFAs)
profiles,
microbial
composition,
expression
barrier
genes.The
average
daily
feed
intake
CTC
group
1-21
d
significantly
higher
than
NC
group,
had
no
statistical
difference
groups.
Compared
gain
EM200
increased
1-42
d.
decreased
levels
lipopolysaccharide
D-lactic
serum
throughout
study.
concentrations
acid,
acetic
propionic
butyric
SCFAs
birds
200
those
chlortetracycline.
dietary
supplementation
chlortetracycline
ileal
SOD1,
Claudin-1
ZO-1
genes.
Dietary
relative
abundances
g_NK4A214_group
Lactobacillus
jejunal,
while
Microbacterium,
Kitasatospora,
Bacteroides
jejunal
Gallibacterium
ileum
decreased.Supplementation
improved
composition
microbiota
regulating
core
bacterial
genus
Lactobacillus,
concentration
metabolites
flora,
thereby
improving
capacity
enhancing
function
tight
junction
proteins.
These
broilers.
The
increasing
emergence
and
dissemination
of
multidrug
resistant
(MDR)
bacterial
pathogens
accelerate
the
desires
for
new
antibiotics.
Natural
products
dominate
preferred
chemical
scaffolds
discovery
antibacterial
agents.
Here,
potential
natural
flavonoids
from
plants
against
MDR
bacteria,
is
demonstrated.
Structure-activity
relationship
analysis
shows
prenylation
modulates
activity
obtains
two
compounds,
α-mangostin
(AMG)
isobavachalcone
(IBC).
AMG
IBC
not
only
display
rapid
bactericidal
Gram-positive
but
also
restore
susceptibility
colistin
Gram-negative
pathogens.
Mechanistic
studies
generally
show
such
compounds
bind
to
phospholipids
membrane,
result
in
dissipation
proton
motive
force
metabolic
perturbations,
through
distinctive
modes
action.
efficacy
four
models
associated
with
infection
or
contamination,
These
results
suggest
that
may
be
a
promising
underappreciated
reservoir
circumvent
existing
antibiotic
resistance.
Frontiers in Pharmacology,
Год журнала:
2021,
Номер
11
Опубликована: Янв. 8, 2021
Background:
Antimicrobial
resistance
represents
a
serious
threat
to
human
health
across
the
globe.
The
cost
of
bringing
new
antibiotic
from
discovery
market
is
high
and
return
on
investment
low.
Furthermore,
development
antibiotics
has
slowed
dramatically
since
1950s’
golden
age
discovery.
Plants
produce
variety
bioactive
secondary
metabolites
that
could
be
used
fuel
future
pipeline.
While
many
studies
have
focused
specific
aspects
plants
plant
natural
products
with
antibacterial
properties,
comprehensive
review
potential
never
before
been
attempted.
Objectives:
This
systematic
aims
evaluate
reports
significant
activities.
Methods:
Following
PRISMA
model,
we
searched
three
electronic
databases:
Web
Science,
PubMed
SciFinder
by
using
keywords:
“plant,”
“antibacterial,”
“inhibitory
concentration.”
Results:
We
identified
total
6,083
articles
published
between
1946
2019
then
reviewed
66%
these
(4,024)
focusing
2012
2019.
A
rigorous
selection
process
was
implemented
clear
inclusion
exclusion
criteria,
yielding
data
958
species
derived
483
scientific
articles.
Antibacterial
activity
found
in
51
79
vascular
orders
throughout
phylogenetic
tree.
Most
are
reported
within
eudicots,
bulk
being
asterids.
not
prominent
monocotyledons.
Phylogenetic
distribution
strongly
supports
concept
chemical
evolution
clades,
especially
more
eudicot
families.
Lamiaceae,
Fabaceae
Asteraceae
were
most
represented
families,
while
Cinnamomum
verum
,
Rosmarinus
vulgaris
Thymus
studied
species.
South
Africa
site
collection.
Crude
extraction
methanol
type
leaves
main
tissue
investigated.
Finally,
Staphylococcus
aureus
targeted
pathogenic
bacteria
studies.
closely
examine
70
medicinal
15
families
literature.
Conclusion:
depicts
current
state
knowledge
regarding
antibacterials
provides
powerful
recommendations
for
research
directions.
Antibiotics,
Год журнала:
2021,
Номер
10(9), С. 1044 - 1044
Опубликована: Авг. 26, 2021
The
extensive
usage
of
antibiotics
and
the
rapid
emergence
antimicrobial-resistant
microbes
(AMR)
are
becoming
important
global
public
health
issues.
Many
solutions
to
these
problems
have
been
proposed,
including
developing
alternative
compounds
with
antimicrobial
activities,
managing
existing
antimicrobials,
rapidly
detecting
AMR
pathogens.
Among
all
them,
employing
such
as
phytochemicals
alone
or
in
combination
other
antibacterial
agents
appears
be
both
an
effective
safe
strategy
for
battling
against
present
review
summarizes
scientific
evidence
on
biochemical,
pharmacological,
clinical
aspects
used
treat
microbial
pathogenesis.
A
wide
range
commercial
products
currently
available
market.
Their
well-documented
efficacy
suggests
that
phytomedicines
valuable
sources
new
types
future
use.
Innovative
approaches
methodologies
identifying
plant-derived
also
proposed
this
review.
Chemical Reviews,
Год журнала:
2022,
Номер
122(18), С. 14722 - 14814
Опубликована: Сен. 1, 2022
Ribosomally
synthesized
and
post-translationally
modified
peptides
(RiPPs)
are
a
natural
product
class
that
has
undergone
significant
expansion
due
to
the
rapid
growth
in
genome
sequencing
data
recognition
they
made
by
biosynthetic
pathways
share
many
characteristic
features.
Their
mode
of
actions
cover
wide
range
biological
processes
include
binding
membranes,
receptors,
enzymes,
lipids,
RNA,
metals
as
well
use
cofactors
signaling
molecules.
This
review
covers
currently
known
modes
action
(MOA)
RiPPs.
In
turn,
mechanisms
which
these
molecules
interact
with
their
targets
provide
rich
set
molecular
paradigms
can
be
used
for
design
or
evolution
new
improved
activities
given
relative
ease
engineering
this
review,
coverage
is
limited
RiPPs
originating
from
bacteria.
Antibiotics,
Год журнала:
2022,
Номер
11(10), С. 1380 - 1380
Опубликована: Окт. 9, 2022
The
overuse
of
antibiotics
in
the
past
decades
has
led
to
emergence
a
large
number
drug-resistant
microorganisms.
In
recent
years,
infection
rate
caused
by
multidrug-resistant
microorganisms
been
increasing,
which
become
one
most
challenging
problems
modern
medicine.
Plant-derived
secondary
metabolites
and
their
derivatives
have
identified
display
significant
antimicrobial
abilities
with
good
tolerance
less
adverse
side
effects,
potentially
having
different
action
mechanisms
microbial
origin.
Thus,
these
phyto-antimicrobials
prospect
treatment
Terpenoids,
alkaloids,
flavonoids
made
up
predominant
part
currently
reported
phytochemicals
activities.
Synthetic
biology
research
around
compounds
is
hotspot
fields
not
only
illuminated
biosynthesis
pathways
but
also
offered
new
methods
for
production.
this
review,
we
discuss
investigations
terpenoid,
alkaloid,
flavonoid
agents—using
artemisinin
oleanolic
acid
(terpenoids),
berberine
colchicine
(alkaloids),
baicalin
(flavonoids)
as
examples—around
mechanisms,
pathway
elucidation,
key
enzyme
identification,
heterologous
production,
order
provide
useful
hints
plant-derived
agent
discovery
development.
Journal of Pharmaceutical Analysis,
Год журнала:
2023,
Номер
13(2), С. 111 - 126
Опубликована: Янв. 6, 2023
Similar
to
blood,
interstitial
fluid
(ISF)
contains
exogenous
drugs
and
biomarkers
may
therefore
substitute
blood
in
drug
analysis.
However,
current
ISF
extraction
techniques
require
bulky
instruments
are
both
time-consuming
complicated,
which
has
inspired
the
development
of
viable
alternatives
such
as
those
relying
on
skin
or
tissue
puncturing
with
microneedles.
Currently,
microneedles
widely
employed
for
transdermal
delivery
have
been
successfully
used
by
different
mechanisms
facilitate
subsequent
The
integration
sensors
enables
situ
analysis
specific
compound
monitoring,
while
monitoring
functions
wearable
devices
allows
real-time
dose
modification.
Herein,
we
review
progress
based
microneedle-assisted
discuss
related
future
opportunities
challenges.
