The Gut–Organ Axis within the Human Body: Gut Dysbiosis and the Role of Prebiotics DOI Creative Commons

Georgia Saxami,

Evangelia N. Kerezoudi, Christos Eliopoulos

и другие.

Life, Год журнала: 2023, Номер 13(10), С. 2023 - 2023

Опубликована: Окт. 8, 2023

The human gut microbiota (GM) is a complex microbial ecosystem that colonises the gastrointestinal tract (GIT) and comprised of bacteria, viruses, fungi, protozoa. GM has symbiotic relationship with its host fundamental for body homeostasis. not limited to scope GIT, but there are bidirectional interactions between other organs, highlighting concept "gut-organ axis". Any deviation from normal composition GM, termed "microbial dysbiosis", implicated in pathogenesis various diseases. Only few studies have demonstrated modifications disease phenotypes, it still unknown whether an altered contributes or simply reflects status. Restoration probiotics prebiotics been postulated, evidence effects limited. Prebiotics substrates "selectively utilized by microorganisms, conferring health benefit". This study highlights vital organs demonstrates dysbiosis emergence certain representative Finally, this article focuses on potential as target therapy manipulate presents gaps literature research.

Язык: Английский

CheckM2: a rapid, scalable and accurate tool for assessing microbial genome quality using machine learning DOI
Alex Chklovski, Donovan H. Parks, Ben J. Woodcroft

и другие.

Nature Methods, Год журнала: 2023, Номер 20(8), С. 1203 - 1212

Опубликована: Июль 27, 2023

Язык: Английский

Процитировано

418
Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide DOI Open Access
Hsin‐Chih Lai,

Tzu-Lung Lin,

Ting-Wen Chen

и другие.

Gut, Год журнала: 2021, Номер 71(2), С. 309 - 321

Опубликована: Март 9, 2021

Chronic obstructive pulmonary disease (COPD) is a global characterised by chronic obstruction of lung airflow interfering with normal breathing. Although the microbiota respiratory tract established to be associated COPD, causality gut in COPD development not yet established. We aimed address connection between composition and development, characterise bacteria their derived active components for amelioration.A murine cigarette smoking (CS)-based model strategies evaluating causal effects were performed. Gut structure was analysed, followed isolation target bacterium. Single cell RNA sequencing, together sera metabolomics analyses performed identify host responsive molecules. Bacteria component isolated, functional assays.Gut significantly affects CS-induced faecal transplantation restores pathogenesis. A commensal bacterium Parabacteroides goldsteinii isolated shown ameliorate COPD. Reduction intestinal inflammation enhancement cellular mitochondrial ribosomal activities colon, systematic restoration aberrant amino acids metabolism sera, inhibition inflammations act as important ameliorative mechanisms. Besides, lipopolysaccharide from P. anti-inflammatory, ameliorates acting an antagonist toll-like receptor 4 signalling pathway.The microbiota-lung axis connected. potentially benefial bacterial strain its may developed used alternative agents prevention or treatment.

Язык: Английский

Процитировано

209
Microbiota medicine: towards clinical revolution DOI Creative Commons
Prisca Gebrayel, Carole Nicco, Souhaila Al Khodor

и другие.

Journal of Translational Medicine, Год журнала: 2022, Номер 20(1)

Опубликована: Март 7, 2022

Abstract The human gastrointestinal tract is inhabited by the largest microbial community within body consisting of trillions microbes called gut microbiota. normal flora site many physiological functions such as enhancing host immunity, participating in nutrient absorption and protecting against pathogenic microorganisms. Numerous investigations showed a bidirectional interplay between microbiota organs intestines, lungs, brain, skin. Large evidence demonstrated, more than decade ago, that alteration key factor pathogenesis local systemic disorders. In this regard, deep understanding mechanisms involved symbiosis/dysbiosis crucial for clinical health field. We review most recent studies on involvement diseases. also elaborate different strategies used to manipulate prevention treatment future medicine strongly related quality our Targeting dysbiosis will be huge challenge.

Язык: Английский

Процитировано

196
Dysbiosis of human gut microbiome in young-onset colorectal cancer DOI Creative Commons
Yongzhi Yang, Lutao Du,

Debing Shi

и другие.

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Ноя. 19, 2021

Abstract The incidence of sporadic young-onset colorectal cancer (yCRC) is increasing. A significant knowledge gap exists in the gut microbiota and its diagnostic value for yCRC patients. Through 16S rRNA gene sequencing, 728 samples are collected to identify microbial markers, an independent cohort 310 used validate results. Furthermore, species-level functional analysis performed by metagenome sequencing using 200 samples. Gut diversity increased yCRC. Flavonifractor plautii important bacterial species yCRC, while genus Streptococcus contains key phylotype old-onset cancer. Functional reveals that has unique characteristics metabolism characterized dominance DNA binding RNA-dependent biosynthetic process. random forest classifier model achieves a powerful classification potential. This study highlights potential biomarkers as promising non-invasive tool accurate detection distinction individuals with

Язык: Английский

Процитировано

164
Gut microbiota dysbiosis contributes to the development of chronic obstructive pulmonary disease DOI Creative Commons
Naijian Li,

Zhouli Dai,

Zhang Wang

и другие.

Respiratory Research, Год журнала: 2021, Номер 22(1)

Опубликована: Окт. 25, 2021

Abstract Background Dysbiosis of the gut microbiome is involved in pathogenesis various diseases, but contribution microbes to progression chronic obstructive pulmonary disease (COPD) still poorly understood. Methods We carried out 16S rRNA gene sequencing and short-chain fatty acid analyses stool samples from a cohort 73 healthy controls, 67 patients with COPD GOLD stages I II severity, 32 III IV severity. Fecal microbiota three groups were then inoculated into recipient mice for total 14 times 28 days induce changes. Furthermore, fecal exposed smoke biomass fuel COPD-like Results observed that varied controls was characterized by distinct overall microbial diversity composition, Prevotella -dominated enterotype lower levels acids. After transplantation patients, exhibited elevated lung inflammation. Moreover, when under both exposure 20 weeks, accelerated declines function, severe emphysematous changes, airway remodeling mucus hypersecretion observed. Conclusion These data demonstrate altered associated model.

Язык: Английский

Процитировано

107
The Bidirectional Gut–Lung Axis in Chronic Obstructive Pulmonary Disease DOI
Lei Wang, Yang Cai, Johan Garssen

и другие.

American Journal of Respiratory and Critical Care Medicine, Год журнала: 2023, Номер 207(9), С. 1145 - 1160

Опубликована: Март 8, 2023

Epidemiological studies indicate that chronic obstructive pulmonary disease (COPD) is associated with the incidence of changes in intestinal health. Cigarette smoking, as one major causes COPD, can have an impact on gastrointestinal system and promotes diseases. This points to existence gut–lung interactions, but overview underlying mechanisms bidirectional connection between lungs gut COPD lacking. The interaction occur through circulating inflammatory cells mediators. Moreover, microbiota dysbiosis, observed both disorders, lead a disturbed mucosal environment, including barrier immune system, hence may negatively affect lungs. Furthermore, systemic hypoxia oxidative stress also be involved dysfunction play role axis. In this review, we summarize data from clinical research, animal models, vitro explain possible interactions COPD. Interesting observations possibility promising future add-on therapies for patients are highlighted.

Язык: Английский

Процитировано

85
Gut microbiota: A new insight into lung diseases DOI Open Access
Peijun Ma, Mengmeng Wang, Yun Wang

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 155, С. 113810 - 113810

Опубликована: Окт. 8, 2022

The human gut microbiota is a complex ecosystem involved in the metabolism, immunity, and health of host. microbiome plays key role development host's innate adaptive immune system, while system orchestrates maintenance host-microbe symbiosis. Lung diseases are usually accompanied by dysbiosis intestinal flora an immune-inflammatory response. its metabolites directly or indirectly regulation host lung disease. However, exact mechanism action gut-lung axis crosstalk remains unclear. This review aimed to summarize latest advances their typical diseases, such as pulmonary hypertension, COPD, cancer. Especially COVID-19, problem troubling world, also discussed it. Moreover, it concentrated on mechanisms between identified specific link among microbiota, metabolites, regulation, which could be used breakthrough find new targets for some without therapeutic drugs clinic. It tool "drug-bacterial interaction" potential applications would provide clear direction future research propose strategy targeting

Язык: Английский

Процитировано

84
Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy DOI
Andrew Maltez Thomas, Marine Fidelle, Bertrand Routy

и другие.

Nature Reviews Clinical Oncology, Год журнала: 2023, Номер 20(9), С. 583 - 603

Опубликована: Июнь 26, 2023

Язык: Английский

Процитировано

73
Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria DOI
Chenhao Li, Martin Stražar, Ahmed M. Mohamed

и другие.

Cell, Год журнала: 2024, Номер 187(8), С. 1834 - 1852.e19

Опубликована: Апрель 1, 2024

Язык: Английский

Процитировано

62
Understanding respiratory microbiome–immune system interactions in health and disease DOI
Sara K. Di Simone, Ina Rudloff, Claudia A. Nold‐Petry

и другие.

Science Translational Medicine, Год журнала: 2023, Номер 15(678)

Опубликована: Янв. 11, 2023

Interactions between the developing microbiome and maturing immune system in early life are critical for establishment of a homeostasis beneficial to both host commensals. The lung harbors diverse community microbes associated with health local or systemic disease. We discuss how colonization changes correlate development disease throughout infancy, childhood, adult life. highlight key advances microbiology, immunology, computational biology that allow investigation functional relevance interactions respiratory system, which may unlock potential microbiome-based therapeutics.

Язык: Английский

Процитировано

42