The gut microbiome and hypertension

Nature Reviews Nephrology, Год журнала: 2023, Номер 19(3), С. 153 - 167

Опубликована: Янв. 11, 2023

Язык: Английский

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Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery?

Pharmacology & Therapeutics, Год журнала: 2023, Номер 251, С. 108549 - 108549

Опубликована: Окт. 23, 2023

Obesity and its comorbidities, including type 2 diabetes mellitus, cardiovascular disease, heart failure non-alcoholic liver disease are a major health economic burden with steadily increasing numbers worldwide. The need for effective pharmacological treatment options is strong, but, until recently, only few drugs have proven sufficient efficacy safety. This article provides comprehensive overview of obesity special focus on organ-specific pathomechanisms. Bariatric surgery as the so far most-effective therapeutic strategy, current future strategies will be discussed. An knowledge about gut-brain axis especially identification physiology incretins unfolds high number potential drug candidates impressive weight-reducing potential. Future multi-modal concepts in may surpass effectivity bariatric not regard to weight loss, but also associated comorbidities.

Язык: Английский

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Effects of Probiotics on Gut Microbiota: An Overview

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6022 - 6022

Опубликована: Май 30, 2024

The role of probiotics in regulating intestinal flora to enhance host immunity has recently received widespread attention. Altering the human gut microbiota may increase predisposition several disease phenotypes such as inflammation and metabolic disorders. converts dietary nutrients into metabolites that serve biologically active molecules modulating regulatory functions host. Probiotics, which are microorganisms, play a versatile restoring composition microbiota, helping improve prevent phenotypes. This comprehensive review provides firsthand information on their influence health, effects diet how alter function along with corresponding building healthy intestine. We also discuss implications some most important diseases. In summary, significant boosting overall immunity, increasing abundance beneficial bacteria, ameliorate symptoms multiple

Язык: Английский

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Antibiotics and the gut microbiome: Understanding the impact on human health

Medicine in Microecology, Год журнала: 2024, Номер 20, С. 100106 - 100106

Опубликована: Апрель 8, 2024

Antibiotic use has become problematic because it unintentionally upsets the delicate equilibrium of human gut microbiota. Antibiotics, especially broad-spectrum ones, that were once regarded as life-saving treatments for bacterial infections instead indiscriminately destroy good bacteria are essential preserving health in addition to their target pathogens. Antibiotic-induced dysbiosis, term this disturbance, sets off a series adverse reactions negatively impact microbiome, resulting decline microbial diversity and creation an environment is favourable establishment strains resistant antibiotics. exposure wide-ranging effects from prenatal adulthood; research shown long-term include increased risk antibiotic resistance, obesity, allergies, asthma, altered metabolic processes. This thorough investigation emphasises critical need more sophisticated knowledge therapy on microbiota necessity implementing all-encompassing solutions reduce its detrimental protect throughout life.

Язык: Английский

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Safety and efficacy of fecal microbiota transplantation (FMT) as a modern adjuvant therapy in various diseases and disorders: a comprehensive literature review

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 26, 2024

The human gastrointestinal (GI) tract microbiome is a complex and all-encompassing ecological system of trillions microorganisms. It plays vital role in digestion, disease prevention, overall health. When this delicate balance disrupted, it can lead to various health issues. Fecal microbiota transplantation (FMT) an emerging therapeutic intervention used as adjuvant therapy for many diseases, particularly those with dysbiosis their underlying cause. Its goal restore by transferring fecal material from healthy donors the recipients. FMT has impressive reported cure rate between 80% 90% become favored treatment diseases. While may have generally mild moderate transient adverse effects, rare severe complications underscore importance rigorous donor screening standardized administration. enormous potential practical approach; however, additional research required further determine its clinical utilization, well safety efficiency different patient populations. This comprehensive literature review offers increased confidence effectiveness several diseases affecting intestines other systems, including diabetes, obesity, inflammatory autoimmune illness, conditions.

Язык: Английский

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The role of the gut microbiota in health and cardiovascular diseases

Molecular Biomedicine, Год журнала: 2022, Номер 3(1)

Опубликована: Окт. 11, 2022

Abstract The gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithelial barrier, regulating immune function, producing vitamins and hormones, metabolites interact with host. Meanwhile, increasing evidence indicates that has a strong correlation occurrence, progression treatment of cardiovascular diseases (CVDs). In patients CVDs corresponding risk factors, composition ratio have significant differences compared their healthy counterparts. Therefore, dysbiosis, microbiota-generated metabolites, related signaling pathway may serve explanations for some mechanisms about occurrence development CVDs. Several studies also demonstrated many traditional latest therapeutic treatments are associated its generated pathways. Given information, we summarized advances in current research regarding effect on main CVDs, highlighted roles several introduced promising microbiota. this review mainly focuses exploring role potential which eventually provide better solutions well prevention

Язык: Английский

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Microbial Dysregulation of the Gut-Lung Axis in Bronchiectasis

American Journal of Respiratory and Critical Care Medicine, Год журнала: 2022, Номер 207(7), С. 908 - 920

Опубликована: Окт. 26, 2022

Rationale: Emerging data support the existence of a microbial "gut-lung" axis that remains unexplored in bronchiectasis. Methods: Prospective and concurrent sampling gut (stool) lung (sputum) was performed cohort n = 57 individuals with bronchiectasis subjected to bacteriome (16S rRNA) mycobiome (18S Internal Transcribed Spacer) sequencing (total, 228 microbiomes). Shotgun metagenomics subset (n 15; 30 Data from compartments were integrated by weighted similarity network fusion, clustered, co-occurrence analysis evaluate gut-lung networks. Murine experiments undertaken validate specific Pseudomonas-driven interactions. Results: Microbial communities stable demonstrate significant interaction. Multibiome integration followed unsupervised clustering reveals two patient clusters, differing interactions contrasting clinical phenotypes. A high interaction cluster, characterized Pseudomonas, Bacteroides, Saccharomyces, is associated increased exacerbations greater radiological overall severity, whereas low cluster demonstrates an overrepresentation commensals, including Prevotella, Fusobacterium, Porphyromonas Candida. The Pseudomonas-gut Bacteroides relationship, observed validated murine model Pseudomonas aeruginosa infection. This abrogated after antibiotic (imipenem) pretreatment mice confirming relevance therapeutic potential targeting microbiome influence axis. Metagenomics corroborated our findings targeted analyses. Conclusions: dysregulated axis, driven associates poorer outcomes

Язык: Английский

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Crosstalk between the gut microbiota and postmenopausal osteoporosis: Mechanisms and applications

International Immunopharmacology, Год журнала: 2022, Номер 110, С. 108998 - 108998

Опубликована: Июль 1, 2022

Язык: Английский

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Probiotics: Protecting Our Health from the Gut

Microorganisms, Год журнала: 2022, Номер 10(7), С. 1428 - 1428

Опубликована: Июль 14, 2022

The gut microbiota (GM) comprises billions of microorganisms in the human gastrointestinal tract. This microbial community exerts numerous physiological functions. Prominent among these functions is effect on host immunity through uptake nutrients that strengthen intestinal cells and involved immune response. GM are not limited to gut, but bidirectional interactions between various extraintestinal organs have been identified. These termed interorganic axes by several authors, which gut-brain, gut-skin, gut-lung, gut-heart, gut-metabolism stand out. It has shown an organism healthy or homeostasis when balance. However, altered dysbiosis represents a critical factor pathogenesis many local systemic diseases. Therefore, probiotics intervene this context, which, according published studies, allows balance be maintained GM, leading individual's good health.

Язык: Английский

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The oral microbiome in autoimmune diseases: friend or foe?

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Март 22, 2023

Abstract The human body is colonized by abundant and diverse microorganisms, collectively known as the microbiome. oral cavity has more than 700 species of bacteria consists unique microbiome niches on mucosal surfaces, tooth hard tissue, in saliva. homeostatic balance between microbiota immune system plays an indispensable role maintaining well-being health status host. Growing evidence demonstrated that dysbiosis actively involved regulating initiation progression array autoimmune diseases. Oral driven multiple factors, such host genetic dietary habits, stress, smoking, administration antibiotics, tissue injury infection. dysregulation a crucial triggering promoting diseases via several mechanisms, including microbial translocation, molecular mimicry, autoantigen overproduction, amplification responses cytokines. Good hygiene behaviors, low carbohydrate diets, healthy lifestyles, usage prebiotics, probiotics or synbiotics, transplantation nanomedicine-based therapeutics are promising avenues for balanced treating microbiota-mediated Thus, comprehensive understanding relationship critical providing novel insights into development microbiota-based therapeutic approaches combating these refractory

Язык: Английский

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