Redox metabolism: ROS as specific molecular regulators of cell signaling and function

Molecular Cell, Год журнала: 2021, Номер 81(18), С. 3691 - 3707

Опубликована: Сен. 1, 2021

Язык: Английский

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Erythrocyte metabolism

Acta Physiologica, Год журнала: 2024, Номер 240(3)

Опубликована: Янв. 25, 2024

Abstract Our aim is to present an updated overview of the erythrocyte metabolism highlighting its richness and complexity. We have manually collected connected available biochemical pathways integrated them into a functional metabolic map. The focus this map on main consisting glycolysis, pentose phosphate pathway, redox metabolism, oxygen purine/nucleoside membrane transport. Other recently emerging are also curated, like methionine salvage glyoxalase system, carnitine lands cycle, as well remnants carboxylic acid metabolism. An additional goal review dynamics providing key numbers used perform basic quantitative analyses. By synthesizing experimental computational data, we conclude that foundations Additionally, can sense levels oxidative stress adjusting mechanics, function. In conclusion, fine‐tuning controls one most important biological processes, is, loading, transport, delivery.

Язык: Английский

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Metabolic and chemical architecture of the mammalian circadian clock

Cell chemical biology, Год журнала: 2023, Номер 30(9), С. 1033 - 1052

Опубликована: Сен. 1, 2023

Язык: Английский

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Benefits of Natural Antioxidants on Oral Health

Antioxidants, Год журнала: 2023, Номер 12(6), С. 1309 - 1309

Опубликована: Июнь 20, 2023

In recent years, special attention has been paid to the correlation between oxidation–reduction mechanisms and human health. The free radicals produced via physiological cellular biochemical processes are major contributors oxidation phenomena. Their instability is cause of damage. Free radical reactive oxygen species containing best-known ones. body neutralises harmful effects production endogenous antioxidants (superoxide dismutase, catalase, glutathione, melatonin). field study nutraucetics found antioxidant capacity in substances such as vitamins A, B, C, E, coenzyme Q-10, selenium, flavonoids, lipoic acid, carotenoids, lycopene contained some foods. There several areas investigation that aim research interaction species, exogenous antioxidants, microbiota promote increased protection peroxidation macromolecules (proteins, lipids) by maintaining a dynamic balance among make up microbiota. this scoping review, we map scientific literature on oxidative stress related oral microbiota, use natural counteract it, assess volume, nature, characteristics, type studies available date, suggest possible gaps will emerge from analysis.

Язык: Английский

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Circadian biology to advance therapeutics for mood disorders

Trends in Pharmacological Sciences, Год журнала: 2023, Номер 44(10), С. 689 - 704

Опубликована: Авг. 28, 2023

Mood disorders account for a significant global disease burden, and pharmacological innovation is needed as existing medications are suboptimal. A wide range of evidence implicates circadian sleep dysfunction in the pathogenesis mood disorders, there growing interest these chronobiological pathways focus treatment innovation. We review contemporary three promising areas circadian-clock-based therapeutics disorders: targeting system informed by mechanistic molecular advances; time-tailoring medications; personalizing using parameters. also consider limitations challenges accelerating development new circadian-informed pharmacotherapies disorders.

Язык: Английский

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Metabolic Reprogramming at the Edge of Redox: Connections Between Metabolic Reprogramming and Cancer Redox State

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 498 - 498

Опубликована: Янв. 9, 2025

The importance of redox systems as fundamental elements in biology is now widely recognized across diverse fields, from ecology to cellular biology. Their connection metabolism particularly significant, it plays a critical role energy regulation and distribution within organisms. Over recent decades, has emerged relevant focus studies biological regulation, especially following its recognition hallmark cancer. This shift broadened cancer research beyond strictly genetic perspectives. interaction between carcinogenesis involves the essential metabolic pathways, such glycolysis Krebs cycle, well involvement redox-active components like specific amino acids cofactors. feedback mechanisms linking highlight development patterns that enhance flexibility adaptability tumor processes, influencing larger-scale phenomena circadian rhythms epigenetics.

Язык: Английский

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Machine learning-guided Orbitrap-HRAMS-based metabolomic fingerprinting for geographical origin, variety and tissue specific authentication, and adulteration detection of turmeric and ashwagandha

Food Chemistry, Год журнала: 2025, Номер unknown, С. 144078 - 144078

Опубликована: Март 1, 2025

Язык: Английский

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Comprehensive Metabolomic Fingerprinting Combined with Chemometrics Identifies Species- and Variety-Specific Variation of Medicinal Herbs: An Ocimum Study

Metabolites, Год журнала: 2023, Номер 13(1), С. 122 - 122

Опубликована: Янв. 13, 2023

Identification of plant species is a crucial process in natural products. Ocimum, often referred to as the queen herbs, one most versatile and globally used medicinal herbs for various health benefits due it having wide variety pharmacological activities. Despite there being significant global demand this herb, rapid comprehensive metabolomic fingerprinting approaches species- variety-specific classification are limited. In study, five Ocimum (Ocimum basilicum L., sanctum africanum Lour., kilimandscharicum Gurke., Hybrid Tulsi) their varieties was performed using LC-MS, GC-MS, approach FT-NIR combined with chemometrics. The aim distinguish variation view toward developing quality assessment species. Discrimination achieved principal component analysis (PCA), partial least squares discriminate (PLS-DA), data-driven soft independent modelling class analogy (DD-SIMCA), random forest, K-nearest neighbours specificity 98% sensitivity 99%. Phenolics flavonoids were found be major contributing markers species-specific variation. present study established consisting screening confirmatory highly efficient means identify able applied other herbs.

Язык: Английский

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Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans

Science Advances, Год журнала: 2024, Номер 10(44)

Опубликована: Окт. 30, 2024

Preclinical models suggest mitochondria-derived oxidative stress as an underlying cause of insulin resistance. However, it remains unknown whether this pathophysiological mechanism is conserved in humans. Here, we used invasive vivo mechanistic approach to interrogate muscle action while selectively manipulating the mitochondrial redox state To end, conducted clamp studies combining intravenous infusion a lipid overload with intake mitochondria-targeted antioxidant (mitoquinone). Under overload, selective modulation by mitoquinone enhanced insulin-stimulated glucose uptake skeletal muscle. Mechanistically, did not affect canonical signaling but augmented transporter type 4 (GLUT4) translocation reducing burden under oversupply. Complementary ex human fibers exposed high intracellular levels revealed that improves features bioenergetics, including diminished H 2 O emission. These findings provide translational and evidence implicating oxidants development lipid-induced resistance

Язык: Английский

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Stroke in the Time of Circadian Medicine

Circulation Research, Год журнала: 2024, Номер 134(6), С. 770 - 790

Опубликована: Март 14, 2024

Time-of-day significantly influences the severity and incidence of stroke. Evidence has emerged not only for circadian governance over stroke risk factors, but also important determinants clinical outcome. In this review, we provide a comprehensive overview interplay between chronobiology cerebrovascular disease. We discuss regulation pathophysiological mechanisms underlying onset or tolerance as well in vascular dementia. This includes cell death mechanisms, metabolism, mitochondrial function, inflammation/immunity. Furthermore, present evidence supporting link disrupted rhythms increased susceptibility to propose that biochemical physiological pathways brain increase damage after sleep attenuate treatment effectiveness during active phase. review underscores importance considering biology understanding pathology choice dementia speculates patient's chronotype may be an factor developing precision following

Язык: Английский

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