Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(31)
Опубликована: Июнь 3, 2022
α-C-H-functionalization
of
ketones
and
aldehydes
has
been
intensively
explored
in
organic
synthesis.
The
functionalization
unactivated
β-C-H
bonds
such
carbonyl
compounds
is
less
well
investigated
developing
a
general
method
for
their
arylation
remains
challenging.
Herein
we
report
that
uses
cooperative
nickel
photoredox
catalysis
the
formal
with
(hetero)aryl
bromides.
features
mild
conditions,
remarkable
scope
wide
functional
group
tolerance.
Importantly,
introduced
synthetic
strategy
also
allows
β-alkenylation,
β-alkynylation
β-acylation
under
similar
conditions.
Mechanistic
studies
revealed
this
transformation
proceeds
through
single
electron
oxidation/Ni-mediated
coupling/reductive
elimination
cascade.
Organic Letters,
Год журнала:
2024,
Номер
26(5), С. 1110 - 1115
Опубликована: Янв. 26, 2024
Despite
the
significant
success
of
decarboxylative
radical
reactions,
catalytic
systems
vary
considerably
upon
different
acceptors,
requiring
renewed
case-by-case
reaction
optimization.
Herein,
we
developed
an
iron
condition
that
enables
highly
efficient
decarboxylation
various
carboxylic
acids
for
a
range
transformations.
This
operationally
simple
protocol
was
amenable
to
wide
array
delivering
structurally
diverse
oxime
ethers,
alkenylation,
alkynylation,
thiolation,
and
amidation
products
in
useful
excellent
yields
(>40
examples,
up
95%
yield).
Organic Process Research & Development,
Год журнала:
2023,
Номер
27(7), С. 1160 - 1184
Опубликована: Март 20, 2023
Earth-abundant
metal
(EAM)
catalysis
can
have
profound
impact
in
the
pharmaceutical
industry
terms
of
sustainability
and
cost
improvements
from
replacing
precious
metals
like
palladium
as
well
harnessing
differential
reactivity
first-row
that
allows
for
novel
transformations
to
enable
more
efficient
routes
clinical
candidates.
The
strategy
building
these
capabilities
within
process
group
at
Bristol
Myers
Squibb
is
described
herein,
with
general
plan
a
reaction
screening
platform,
demonstrating
scalability,
increasing
mechanistic
understanding
catalyst
activation.
development
catalytic
utilizing
nickel,
cobalt,
iron
while
highlighting
importance
collaboration
internal
external
groups
advance
EAM
our
portfolio.
challenges
benefits
working
transition
metals,
including
metrics
implementation
catalysis,
such
cost,
mass
intensity,
commercial
availability
catalysts
ligands,
are
discussed.
Journal of Biological Engineering,
Год журнала:
2023,
Номер
17(1)
Опубликована: Июнь 8, 2023
Abstract
Skin
is
the
largest
organ
of
human
body.
It
plays
a
vital
role
as
body’s
first
barrier:
stopping
chemical,
radiological
damage
and
microbial
invasion.
The
importance
skin
to
body
can
never
be
overstated.
Delayed
wound
healing
after
injury
has
become
huge
challenge
in
healthcare.
In
some
situations,
this
have
very
serious
even
life-threatening
effects
on
people’s
health.
Various
dressings
been
developed
promote
quicker
healing,
including
hydrogels,
gelatin
sponges,
films,
bandages,
all
work
prevent
invasion
pathogens.
Some
them
are
also
packed
with
bioactive
agents,
such
antibiotics,
nanoparticles,
growth
factors,
that
help
improve
performance
dressing
it
added
to.
Recently,
nanoparticles
agent
widely
used
dressings.
Among
these,
functional
inorganic
favored
due
their
ability
effectively
tissue-repairing
properties
biomaterials.
MXene
attracted
interest
scholars
unique
electrical
conductivity,
hydrophilicity,
antibacterial
properties,
biocompatibility.
potential
for
its
application
promising
an
effective
component
paper,
we
will
review
repair,
particularly
synthesis
method,
biocompatibility,
application.
Nanoscale,
Год журнала:
2023,
Номер
15(12), С. 5579 - 5597
Опубликована: Янв. 1, 2023
Progress
of
MXene
nanocomposite
films
with
different
layer
structures
light
weight,
high
flexibility,
mechanical
strength,
good
hydrophobicity,
and
multifunctionality
for
EMI
shielding.
Nature Synthesis,
Год журнала:
2023,
Номер
2(11), С. 1116 - 1126
Опубликована: Июль 10, 2023
Abstract
Multi-catalytic
reaction
modes
have
attracted
widespread
attention
in
synthetic
chemistry.
The
merger
of
nickel
catalysis
with
photoredox
has
offered
a
powerful
platform
for
synthesis
molecules
attractive
properties.
Nonetheless,
the
conceptual
development
nickel-catalysed,
sensitized
electron
transfer
is
pivotal
relevance,
but
still
greatly
limited.
Here
we
describe
radical
cross-thioesterification
process
by
nickel-catalysed
transfer.
strategy
can
produce
diverse
methyl
thioesters,
which
are
not
only
found
natural
products,
materials
and
pharmaceuticals
also
precursors
chemistry
biological
processes.
This
catalytic
mode
features
high
chemoselectivity,
good
functional
group
tolerance
excellent
scalability.
Perhaps
more
important
was
finding
that
various
drugs
amino
acids
were
successfully
functionalized
this
system.
Experimental
studies,
nanosecond
transient
spectroscopic
analysis,
density
theory
calculations
reveal
photocatalytic
transfer,
energy
plays
an
essential
role
thioesterification
reaction.
Chemical Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Cross-electrophile
coupling
(XEC),
defined
by
us
as
the
cross-coupling
of
two
different
σ-electrophiles
that
is
driven
catalyst
reduction,
has
seen
rapid
progression
in
recent
years.
As
such,
this
review
aims
to
summarize
field
from
its
beginnings
up
until
mid-2023
and
provide
comprehensive
coverage
on
synthetic
methods
current
state
mechanistic
understanding.
Chapters
are
split
type
bond
formed,
which
include
C(sp
The
development
of
the
proton
exchange
membrane
water
electrolyzer
(PEMWE)
is
still
limited
by
prohibitive
cost
and
scarcity
iridium
(Ir)-based
oxygen
evolution
reaction
(OER)
catalyst.
This
work
presents
a
novel
catalyst
synthesized
precursor-atomization
rapid
joule-heating
method,
successfully
doping
atoms
into
polyvalent
tungsten
blends
(W
Abstract
Extremely
low‐frequency
(ELF)
electromagnetic
(EM)
waves
adeptly
propagate
in
harsh
cross‐medium
environments,
overcoming
rapid
decay
that
hinders
high‐frequency
counterparts.
Traditional
antennas,
however,
encounter
challenges
concerning
size,
efficiency,
and
power.
Here,
drawing
inspiration
from
nature,
we
present
a
groundbreaking
piezo‐actuated,
bionic
flapping‐wing
magnetic‐dipole
resonator
(BFW‐MDR),
operating
the
electro‐mechano‐magnetic
coupling
mechanism,
designed
for
efficient
ELF
EM
wave
transmission.
The
unique
rigid‐flexible
hybrid
structure
magnifies
rotation
angles
of
anti‐phase
magnetic
dipoles
by
tenfold,
leading
to
constructive
superposition
emitted
fields.
Consequently,
BFW‐MDR
exhibits
remarkable
quality
factor
288
an
enhanced
field
emission
514
fT
at
100
meters
with
only
6.9
mW
power
consumption,
surpassing
traditional
coil
antennas
three
orders
magnitude.
communication
rate
is
doubled
ASK+PSK
modulation
method.
Its
robust
performance
communication,
even
amidst
various
interferences,
underscores
its
potential
as
highly
antenna
underwater
underground
applications.
The
rational
design
of
visible-light-responsive
catalysts
is
crucial
for
converting
solar
energy
into
hydrogen
to
promote
sustainable
development.
In
this
work,
a
C─S─C
bond
introduced
g-C
