Chemical Science,
Год журнала:
2024,
Номер
15(24), С. 9016 - 9025
Опубликована: Янв. 1, 2024
Initial
calculations
of
environmental
footprints
associated
with
using
Ni
vs
Pd
catalysis
in
a
representative
metal-catalyzed
Suzuki–Miyaura
cross-coupling
reveal
that
the
choice
ligated
metal
is
often
NOT
consequence.
Rather,
it
culmination
other
parameters
such
as
medium.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(9), С. 6360 - 6368
Опубликована: Фев. 23, 2024
Nickel-catalyzed
Suzuki–Miyaura
coupling
(Ni-SMC)
offers
the
potential
to
reduce
cost
of
pharmaceutical
process
synthesis.
However,
its
application
has
been
restricted
by
challenges
such
as
slow
reaction
rates,
high
catalyst
loading,
and
a
limited
scope
heterocycles.
Despite
recent
investigations,
mechanism
transmetalation
in
Ni-SMC,
often
viewed
turnover-limiting
step,
remains
insufficiently
understood.
We
elucidate
"Ni-oxo"
pathway,
applying
PPh2Me
ligand,
identify
formation
nickel-oxo
intermediate
step.
Building
on
this
insight,
we
develop
scaffolding
ProPhos,
featuring
pendant
hydroxyl
group
connected
phosphine
via
linker.
The
design
preorganizes
both
nucleophile
nickel
catalyst,
thereby
facilitating
transmetalation.
This
exhibits
fast
kinetics
robust
activity
across
wide
range
heteroarenes,
with
loading
0.5–3
mol
%.
For
arene
substrates,
can
be
further
reduced
0.1
Substitution
of
one
metal
catalyst
for
another
is
not
straightforward
as
simply
justifying
this
change
based
on
the
availability
and/or
cost
metals.
A
life
cycle-like
assessment
was
performed
leading
to
conclusion
that
commonly
held
view
use
earth-abundant
metals
(and
in
case
study,
Ni)
are
replacements
palladium
most
notably
cross
coupling
reactions,
and
Suzuki-Miyaura
couplings,
particular,
an
incomplete
analysis
entire
picture.
This
notion
can
be
misleading,
unfortunately
derives
nowadays
mainly
from
standpoint
cost,
some
degree,
relative
natural
abundance
mining
impact
each
metal.
However,
a
more
realistic
appreciation
emerges
when
several
additional
reaction
parameters
involved
couplings
considered.
Such
unequivocally
points
major
climate
brought
about
by
organic
solvents,
while
actually
play
subordinate
roles
terms
CO2-release
into
environment.
Clearly,
study
reveals
factors
contribute
various
ways
overall
carbon
footprint.
Hence,
far
detailed
required
than
typically
being
utilized!
Cell Reports Physical Science,
Год журнала:
2023,
Номер
4(9), С. 101548 - 101548
Опубликована: Авг. 21, 2023
This
perspective
provides
an
entry-level
conversation
concerning
base
metal
catalysis
as
a
green
and
sustainable
solution
in
industrial
academic
contexts.
We
establish
definition
of
"base
metal,"
challenging
readers
to
consider
the
ethical
implications
sourcing.
explore
what
it
means
be
"sustainable"
provide
information
on
current
efforts
synthetic
chemistry.
examples
catalytic
trends
transformations
popular
fields
such
cross-coupling
small-molecule
conversion,
highlighting
relevant
systems.
Finally,
we
social
context—for
example,
decisions
related
catalyst
development
are
often
driven
by
factors
including
costliness,
safety,
adoptability
(whether
society
will
accept
its
usage),
performance.
How
do
move
forefront?
Is
concerned
if
materials
fabricated
from
cheaper
more
abundant
sources?
does
chemistry
community
guide
this
knowledge
translation?
Organometallics,
Год журнала:
2023,
Номер
42(21), С. 3164 - 3172
Опубликована: Ноя. 1, 2023
A
general
method
for
the
Ni-catalyzed
Buchwald–Hartwig
amination
of
(hetero)aryl
chlorides
using
both
anilines
and
aliphatic
amines
under
homogeneous
conditions
has
been
developed.
Key
to
success
this
is
implementation
a
dual-base
strategy
that
utilizes
an
amine
base
combined
with
soluble
halide
scavenger
allows
use
single
air-stable,
commercially
available
Ni(II)-precatalyst
phosphine
ligand
[(R,S)-Josiphos]
combination
promote
aminations
across
broad
scope
pharmaceutically
relevant
nucleophiles
at
catalyst
loadings
as
low
1.0
mol
%.
Organic Process Research & Development,
Год журнала:
2024,
Номер
28(2), С. 559 - 576
Опубликована: Янв. 31, 2024
Process
development
activities
required
to
develop
a
robust
and
scalable
synthetic
route
AZD7594
(1)
are
disclosed.
Included
in
this
paper
is
the
rationale
for
selection
of
palladium-mediated
Buchwald–Hartwig
coupling
form
key
C–N
bond.
Reaction
optimization
understanding
were
performed
minimize
impurity
formation
control
strategy.
The
optimized
sequence
was
used
manufacture
220
kg
clinical
trials.
Materials,
Год журнала:
2025,
Номер
18(2), С. 263 - 263
Опубликована: Янв. 9, 2025
There
is
a
growing
focus
on
sustainability,
characterized
by
making
changes
that
anticipate
future
needs
and
adapting
them
to
present
requirements.
Sustainability
reflected
in
various
areas
of
materials
science
as
well.
Thus,
more
research
focused
the
fabrication
advanced
based
earth-abundant
metals.
The
role
iron
its
alloys
particularly
significant
second
most
abundant
metal
our
planet.
Additionally,
electrochemical
method
offers
an
environmentally
friendly
approach
for
synthesizing
multifunctional
alloys.
can
be
successfully
codeposited
with
targeted
from
complexing
electrolytes,
opening
large
horizon
smart
tuning
properties
enabling
applications.
In
this
review,
we
discuss
practical
aspects
electrodeposition
iron-based
refractory
metals
having
magnetic,
catalytic,
mechanical,
antimicrobial/antibacterial
thermal,
wear,
corrosion
resistance.
Peculiarities
electrolytes
are
practically
they
greatly
influence
final
structure,
composition,
designed
adjusting
electroactive
complexes
solution.
Moreover,
these
further
upgraded
into
composites,
multi-layered,
hybrid/recovered
materials,
or
high-entropy
