Common infections and neuroimaging markers of dementia in three UK cohort studies DOI Creative Commons

Rebecca Green,

Carole H. Sudre, Charlotte Warren‐Gash

и другие.

Alzheimer s & Dementia, Год журнала: 2024, Номер 20(3), С. 2128 - 2142

Опубликована: Янв. 22, 2024

Abstract INTRODUCTION We aimed to investigate associations between common infections and neuroimaging markers of dementia risk (brain volume, hippocampal white matter lesions) across three population‐based studies. METHODS tested serology measures (pathogen serostatus, cumulative burden, continuous antibody responses) outcomes using linear regression, including adjustments for total intracranial volume scanner/clinic information (basic model), age, sex, ethnicity, education, socioeconomic position, alcohol, body mass index, smoking (fully adjusted model). Interactions apolipoprotein E ( APOE ) genotype were tested. Findings meta‐analyzed cohorts N main = 2632; APOE‐interaction 1810). RESULTS Seropositivity John Cunningham virus associated with smaller brain volumes in basic models (β −3.89 mL [−5.81, −1.97], P < 0.05); these largely attenuated fully −1.59 [−3.55, 0.36], 0.11). No other relationships robust multiple testing corrections sensitivity analyses, but several suggestive observed. DISCUSSION did not find clear evidence risk. Some findings warrant replication.

Язык: Английский

Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom DOI Creative Commons
Ashvin Kuri, Benjamin Meir Jacobs,

Nikki Vickaryous

и другие.

BMC Public Health, Год журнала: 2020, Номер 20(1)

Опубликована: Июнь 12, 2020

Abstract Background Epstein-Barr Virus (EBV) is a ubiquitous gamma-herpesvirus with which ~ 95% of the healthy population infected. EBV infection has been implicated in range haematological malignancies and autoimmune diseases. Delayed primary increases risk subsequent complications. Contemporaneous seroepidemiological data needed to establish best approaches for successful vaccination strategies future. Methods We conducted sero-epidemiological survey using serum samples from 2325 individuals between 0 25 years old assess prevalence detectable anti-EBV antibodies. Second, we retrospective review Hospital Episode Statistics examine changes Infectious Mononucleosis (IM) incidence over time. then large case-control study 6306 prevalent IM cases 1,009,971 unmatched controls extracted an East London GP database determine exposures associated IM. Results 1982/2325 (85.3%) were seropositive. seropositivity increased more rapidly females than males during adolescence (age 10–15). Between 2002 2013, (derived hospital admissions data) increased. Exposures lower BMI, White ethnicity, not smoking. Conclusions report that overall seroprevalence UK appears have increased, sharp increase seen adolescent females, but males. The requiring hospitalisation increasing. diverse include white never-smoking, these interact each other. Lastly, provide pilot evidence suggesting antibody responses vaccine commonly encountered pathogens do appear be diminished among EBV-seronegative individuals. Our findings could help inform designs efforts prevent late complications infection, such as Multiple Sclerosis.

Язык: Английский

Процитировано

160
UK Biobank: a globally important resource for cancer research DOI Creative Commons
Megan Conroy, Ben Lacey,

Jelena Bešević

и другие.

British Journal of Cancer, Год журнала: 2022, Номер 128(4), С. 519 - 527

Опубликована: Ноя. 19, 2022

UK Biobank is a large-scale prospective study with deep phenotyping and genomic data. Its open-access policy allows researchers worldwide, from academia or industry, to perform health research in the public interest. Between 2006 2010, recruited 502,000 adults aged 40-69 years general population of United Kingdom. At enrolment, participants provided information on wide range factors, physical measurements were taken, biological samples (blood, urine saliva) collected for long-term storage. Participants have now been followed up over decade more than 52,000 incident cancer cases recorded. The continues be enhanced repeat assessments, web-based questionnaires, multi-modal imaging, conversion stored other '-omic' has already demonstrated its value enabling into determinants cancer, future planned enhancements will make resource even valuable researchers. Over 26,000 worldwide are currently using data, performing research. uniquely placed transform our understanding causes development progression, drive improvements treatment prevention coming decades.

Язык: Английский

Процитировано

91
Helicobacter pylori infection in humans and phytotherapy, probiotics, and emerging therapeutic interventions: a review DOI Creative Commons

Mengkai Liu,

Hui Gao, Jinlai Miao

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 14

Опубликована: Янв. 10, 2024

The global prevalence of

Язык: Английский

Процитировано

18
The landscape of host genetic factors involved in immune response to common viral infections DOI Creative Commons
Linda Kachuri, Stephen Francis, Maike L. Morrison

и другие.

Genome Medicine, Год журнала: 2020, Номер 12(1)

Опубликована: Окт. 27, 2020

Abstract Background Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the mechanisms of immune response to viral infection provides insight into disease etiology therapeutic opportunities. Methods We conducted comprehensive study including genome-wide transcriptome-wide association analyses identify loci associated with immunoglobulin G antibody 28 antigens 16 using serological data from 7924 European ancestry participants UK Biobank cohort. Results Signals human leukocyte antigen (HLA) class II region dominated landscape response, 40 independent 14 classical alleles, 7 which exhibited pleiotropic effects across families. identified specific amino acid (AA) residues that are seroreactivity, strongest associations presented range AA positions within DRβ1 at 11, 13, 71, 74 Epstein-Barr virus (EBV), Varicella zoster (VZV), herpesvirus 7, (HHV7), Merkel cell polyomavirus (MCV). Genome-wide discovered novel outside HLA ( P < 5.0 × 10 −8 ), FUT2 (19q13.33) BK (BKV), STING1 (5q31.2) MCV, CXCR5 (11q23.3) TBKBP1 (17q21.32) HHV7. Transcriptome-wide 114 genes infection, 12 region, ECSCR : = −15 (MCV), NTN5 1.1 −9 P2RY13 EBV nuclear antigen. also demonstrated pleiotropy between diseases, autoimmune disorders cancer neurodegenerative psychiatric conditions. Conclusions Our confirms importance elucidates determinants beyond contribute host-virus interaction.

Язык: Английский

Процитировано

98
Integrated Serosurveillance of Infectious Diseases Using Multiplex Bead Assays: A Systematic Review DOI Creative Commons
Selina Ward, Harriet Lawford,

Benn Sartorius

и другие.

Tropical Medicine and Infectious Disease, Год журнала: 2025, Номер 10(1), С. 19 - 19

Опубликована: Янв. 10, 2025

Integrated serological surveillance (serosurveillance) involves testing for antibodies to multiple pathogens (or species) simultaneously and can be achieved using multiplex bead assays (MBAs). This systematic review aims describe studied MBAs, the operational implementation of how data generated were synthesised. In November December 2023, four databases searched studies utilising MBAs integrated serosurveillance infectious diseases. Two reviewers independently screened extracted regarding study settings population, methodology, seroprevalence results, elements. Overall, 4765 identified; 47 eligible inclusion, which 41% (n = 19) investigated malaria species, 14% performed concurrent in combination with other diseases 14). Additionally, 14 (29%) a (other than malaria), seven examined vaccine-preventable Haiti 8) was most country, followed by Ethiopia 6), Bangladesh 3), Kenya Tanzania 3). Only found where primary objective. The synthesis varied included investigation age-specific 25), risk factor analysis 15), spatial disease prevalence 8). demonstrated that use is gaining traction; however, more research capabilities lower- middle-income countries are needed optimise standardise sample collection, survey implementation, interpretation results. Geographical population enable targeted public health interventions, highlighting potential importance as tool.

Язык: Английский

Процитировано

1
Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation DOI Creative Commons
Ken Sagou, Yoshitaka Sato, Yusuke Okuno

и другие.

PLoS Pathogens, Год журнала: 2024, Номер 20(2), С. e1011954 - e1011954

Опубликована: Фев. 1, 2024

Epstein-Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus that causally associated with several malignancies. In addition to latent factors, lytic replication contributes cancer development. this study, we examined whether the gene BNRF1, which conserved among gamma-herpesviruses, has an important role in lymphomagenesis. We found lymphoblastoid cell lines (LCLs) established by BNRF1-knockout EBV exhibited remarkably lower pathogenicity mice xenograft model than LCLs produced wild-type (LCLs-WT). RNA-seq analyses revealed BNRF1 elicited expression of interferon-inducible protein 27 (IFI27), promotes proliferation. IFI27 knockdown LCLs-WT resulted excessive production reactive oxygen species, leading death and significantly decreased their vivo . also confirmed was upregulated during primary infection B-cells. Our findings promoted robust proliferation B-cells were transformed via upregulation both vitro

Язык: Английский

Процитировано

6
Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review DOI Creative Commons
Pinja Kettunen, Jari Koıstınaho, Taisia Rõlova

и другие.

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Июнь 6, 2024

Abstract Central nervous system infections have been suggested as a possible cause for neurodegenerative diseases, particularly sporadic cases. They trigger neuroinflammation which is considered integrally involved in processes. In this review, we will look at data linking variety of viral, bacterial, fungal, and protozoan to Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, multiple sclerosis unspecified dementia. This narrative review aims bring together broad range currently supporting the involvement central development diseases. The idea that no single pathogen or group responsible diseases be discussed. Instead, suggest wide susceptibility factors may make individuals differentially vulnerable different infectious pathogens subsequent pathologies.

Язык: Английский

Процитировано

5
The landscape of host genetic factors involved in immune response to common viral infections DOI Creative Commons
Linda Kachuri, Stephen Francis, Maike L. Morrison

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2020, Номер unknown

Опубликована: Май 7, 2020

ABSTRACT Introduction Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the mechanisms of immune response to viral infection provides insight into disease etiology therapeutic opportunities. Methods We conducted comprehensive study including genome-wide transcriptome-wide association analyses identify loci associated with immunoglobulin G antibody 28 antigens 16 using serological data from 7924 European ancestry participants UK Biobank cohort. Results Signals human leukocyte antigen (HLA) class II region dominated landscape response, 40 independent 14 classical alleles, 7 which exhibited pleiotropic effects across families. identified specific amino acid (AA) residues that are seroreactivity, strongest associations presented range AA positions within DRβi at 11, 13, 71, 74 Epstein-Barr Virus (EBV), Varicella Zoster (VZV), Human Herpes virus 7, (HHV7) Merkel cell polyomavirus (MCV). Genome-wide discovered novel outside HLA ( P <5.0×10 -8 ), FUT2 (19q13.33) BK (BKV), STING1 (5q31.2) MCV, as well CXCR5 (11q23.3) TBKBP1 (17q21.32) HHV7. Transcriptome-wide 114 genes infection, 12 region, ECSCR : P=5.0*10 -15 (MCV), NTN5: P=1.1×10 -9 P2RY13: EBV nuclear antigen. also demonstrated pleiotropy between diseases; autoimmune disorders cancer neurodegenerative psychiatric conditions. Conclusions Our confirms importance elucidates determinants beyond contribute host-virus interaction.

Язык: Английский

Процитировано

34
Characterization of human papillomavirus (HPV) 16 E6 seropositive individuals without HPV-associated malignancies after 10 years of follow-up in the UK Biobank DOI Creative Commons
Nicole Brenner, Alexander J. Mentzer, Michael Hill

и другие.

EBioMedicine, Год журнала: 2020, Номер 62, С. 103123 - 103123

Опубликована: Ноя. 25, 2020

Antibodies against the HPV16 oncoprotein E6 are promising biomarkers for HPV16-driven oropharyngeal cancer (HPV16-OPC) due to their high sensitivity and specificity, prospective manifestation. In previous studies, 0•7% of controls without HPV-associated malignancies were seropositive which only a minority is expected develop cancer. We aimed characterise antibodies in individuals malignancies.

Язык: Английский

Процитировано

34
Genome‐Wide Association Analyses of HPV16 and HPV18 Seropositivity Identify Susceptibility Loci for Cervical Cancer DOI Creative Commons

Theresa Beckhaus,

Linda Kachuri, Taishi Nakase

и другие.

Journal of Medical Virology, Год журнала: 2025, Номер 97(2)

Опубликована: Янв. 31, 2025

Infection by high-risk human papillomavirus is known to exacerbate cervical cancer development. The host immune response crucial in disease regression. Large-scale genetic association studies for have identified few susceptibility variants, mainly at the leukocyte antigen locus on chromosome 6. We hypothesized that modifies risk and performed three genome-wide analyses HPV16, HPV18 HPV16/18 seropositivity 7814, 7924, 7924 samples from UK Biobank, followed validation genotyping German Cervigen case-control series of dysplasia. In GWAS analyses, we two loci associated with HPV16 (6p21.32 15q26.2), (5q31.2 14q24.3), one and/or (at 6p21.32). MAGMA gene-based analysis HLA-DQA1 HLA-DQB1 as significant (GWS) genes. genotyping, lead variant 6p21.32, rs9272293 overall (OR = 0.86, p 0.004, 95% CI 0.78-0.95, n 3710) positive invasive 0.73, 0.005, 0.59-0.91, 1431). This was found be a robust eQTL HLA-DRB1, HLA-DQB1-AS1, C4B, HLA-DRB5, HLA-DRB6, HLA-DQB1, HLA-DPB1 epithelial tissue samples. additionally genotyped twenty-four HPV variants below GWS threshold out which eleven were our cohort, suggesting further may determine outcome. Our study identifies novel genomic associate type-specific dysplasia provides evidence candidate genes loci.

Язык: Английский

Процитировано

0