Common infections and neuroimaging markers of dementia in three UK cohort studies DOI Creative Commons

Rebecca Green,

Carole H. Sudre, Charlotte Warren‐Gash

и другие.

Alzheimer s & Dementia, Год журнала: 2024, Номер 20(3), С. 2128 - 2142

Опубликована: Янв. 22, 2024

Abstract INTRODUCTION We aimed to investigate associations between common infections and neuroimaging markers of dementia risk (brain volume, hippocampal white matter lesions) across three population‐based studies. METHODS tested serology measures (pathogen serostatus, cumulative burden, continuous antibody responses) outcomes using linear regression, including adjustments for total intracranial volume scanner/clinic information (basic model), age, sex, ethnicity, education, socioeconomic position, alcohol, body mass index, smoking (fully adjusted model). Interactions apolipoprotein E ( APOE ) genotype were tested. Findings meta‐analyzed cohorts N main = 2632; APOE‐interaction 1810). RESULTS Seropositivity John Cunningham virus associated with smaller brain volumes in basic models (β −3.89 mL [−5.81, −1.97], P < 0.05); these largely attenuated fully −1.59 [−3.55, 0.36], 0.11). No other relationships robust multiple testing corrections sensitivity analyses, but several suggestive observed. DISCUSSION did not find clear evidence risk. Some findings warrant replication.

Язык: Английский

Editorial: Current research on serological analyses of infectious diseases DOI Creative Commons
Eric Rogier, Emanuele Giorgi, Kevin K. A. Tetteh

и другие.

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Фев. 17, 2023

EDITORIAL article Front. Med., 17 February 2023Sec. Infectious Diseases: Pathogenesis and Therapy Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1154584

Язык: Английский

Процитировано

8
The immunogenetics of viral antigen response is associated with subtype-specific glioma risk and survival DOI Creative Commons
Geno Guerra, Linda Kachuri, George A. Wendt

и другие.

The American Journal of Human Genetics, Год журнала: 2022, Номер 109(6), С. 1105 - 1116

Опубликована: Май 11, 2022

Язык: Английский

Процитировано

13
Cancers attributable to infectious agents in Italy DOI
Giulia Collatuzzo, Carlo La Vecchia, Fabio Parazzini

и другие.

European Journal of Cancer, Год журнала: 2023, Номер 183, С. 69 - 78

Опубликована: Янв. 25, 2023

Язык: Английский

Процитировано

6
A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy DOI Creative Commons
Amanda Y. Chong, Nicole Brenner,

Andrés Jimenez-Kaufmann

и другие.

The American Journal of Human Genetics, Год журнала: 2024, Номер 111(2), С. 295 - 308

Опубликована: Янв. 21, 2024

Язык: Английский

Процитировано

2
Common infections and neuroimaging markers of dementia in three UK cohort studies DOI Creative Commons

Rebecca Green,

Carole H. Sudre, Charlotte Warren‐Gash

и другие.

Alzheimer s & Dementia, Год журнала: 2024, Номер 20(3), С. 2128 - 2142

Опубликована: Янв. 22, 2024

Abstract INTRODUCTION We aimed to investigate associations between common infections and neuroimaging markers of dementia risk (brain volume, hippocampal white matter lesions) across three population‐based studies. METHODS tested serology measures (pathogen serostatus, cumulative burden, continuous antibody responses) outcomes using linear regression, including adjustments for total intracranial volume scanner/clinic information (basic model), age, sex, ethnicity, education, socioeconomic position, alcohol, body mass index, smoking (fully adjusted model). Interactions apolipoprotein E ( APOE ) genotype were tested. Findings meta‐analyzed cohorts N main = 2632; APOE‐interaction 1810). RESULTS Seropositivity John Cunningham virus associated with smaller brain volumes in basic models (β −3.89 mL [−5.81, −1.97], P < 0.05); these largely attenuated fully −1.59 [−3.55, 0.36], 0.11). No other relationships robust multiple testing corrections sensitivity analyses, but several suggestive observed. DISCUSSION did not find clear evidence risk. Some findings warrant replication.

Язык: Английский

Процитировано

2