Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

Molecular Psychiatry, Год журнала: 2024, Номер 29(6), С. 1869 - 1881

Опубликована: Фев. 9, 2024

Abstract Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying layout. We tested large-scale structural in schizophrenia relate to normative and functional connectome architecture, systematically evaluated robustness generalizability of network-level alterations. Leveraging anatomical MRI scans from 2439 adults 2867 healthy controls 26 ENIGMA sites data Human Connectome Project ( n = 207), we against two susceptibility models: (i) hub vulnerability, which examines associations between regional centrality magnitude disease-related alterations; (ii) epicenter mapping, identifies regions whose typical connectivity profile most closely resembles morphological To assess specificity, contextualized influence site, disease stages, individual clinical factors compared that found affective disorders. Our findings show schizophrenia-related cortical thinning spatially associated hubs, suggesting highly interconnected are more vulnerable Predominantly temporo-paralimbic frontal emerged as epicenters profiles linked schizophrenia’s alteration patterns. Findings were robust across sites, related symptoms. Moreover, transdiagnostic comparisons revealed overlapping bipolar, but not major depressive disorder, suggestive pathophysiological continuity within schizophrenia-bipolar-spectrum. In sum, over course follow brain emphasizing marked temporo-frontal at both level group individual. Subtle variations stages suggest interacting pathological processes, while patient-specific symptoms support additional inter-individual variability vulnerability schizophrenia. work outlines potential pathways better understand macroscale inter-

Язык: Английский

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Towards a biologically annotated brain connectome

Nature reviews. Neuroscience, Год журнала: 2023, Номер 24(12), С. 747 - 760

Опубликована: Окт. 17, 2023

Язык: Английский

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Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis

JAMA Psychiatry, Год журнала: 2023, Номер 80(12), С. 1246 - 1246

Опубликована: Сен. 20, 2023

Psychotic illness is associated with anatomically distributed gray matter reductions that can worsen progression, but the mechanisms underlying specific spatial patterning of these changes unknown.

Язык: Английский

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Integrating multimodal and multiscale connectivity blueprints of the human cerebral cortex in health and disease

PLoS Biology, Год журнала: 2023, Номер 21(9), С. e3002314 - e3002314

Опубликована: Сен. 25, 2023

The brain is composed of disparate neural populations that communicate and interact with one another. Although fiber bundles, similarities in molecular architecture, synchronized activity all reflect how regions potentially another, a comprehensive study these interregional relationships jointly structure function remains missing. Here, we systematically integrate 7 multimodal, multiscale types similarity ("connectivity modes") derived from gene expression, neurotransmitter receptor density, cellular morphology, glucose metabolism, haemodynamic activity, electrophysiology humans. We first show for connectivity modes, feature decreases distance increases when are structurally connected. Next, modes exhibit unique diverse connection patterns, hub profiles, spatial gradients, modular organization. Throughout, observe consistent primacy modes-namely correlated expression similarity-that map onto multiple phenomena, including the rich club patterns abnormal cortical thickness across 13 neurological, psychiatric, neurodevelopmental disorders. Finally, to construct single multimodal wiring human cortex, fuse fused network maps major organizational features cortex structural connectivity, intrinsic functional networks, cytoarchitectonic classes. Altogether, this work contributes integrative cerebral cortex.

Язык: Английский

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Where do neurodevelopmental conditions fit in transdiagnostic psychiatric frameworks? Incorporating a new neurodevelopmental spectrum

World Psychiatry, Год журнала: 2024, Номер 23(3), С. 333 - 357

Опубликована: Сен. 16, 2024

Features of autism spectrum disorder, attention‐deficit/hyperactivity learning disorders, intellectual disabilities, and communication motor disorders usually emerge early in life are associated with atypical neurodevelopment. These “neurodevelopmental conditions” grouped together the DSM‐5 ICD‐11 to reflect their shared characteristics. Yet, reliance on categorical diagnoses poses significant challenges both research clinical settings (e.g., high co‐occurrence, arbitrary diagnostic boundaries, within‐disorder heterogeneity). Taking a transdiagnostic dimensional approach provides useful alternative for addressing these limitations, accounting underpinnings across neurodevelopmental conditions, characterizing common co‐occurrence developmental continuity other psychiatric conditions. Neurodevelopmental features have not been adequately considered frameworks, although this would fundamental implications practices. Growing evidence from studies structure conditions indicates that cluster together, delineating spectrum” ranging normative impairing profiles. Studies genetic underpinnings, overlapping cognitive neural profiles, similar course efficacy support/treatment strategies indicate validity spectrum. Further, alongside dimensions has utility, as it fuller view an individual's needs strengths, greater prognostic utility than categories. Based compelling body evidence, we argue incorporating new into frameworks considerable potential transforming our understanding, classification, assessment, practices around

Язык: Английский

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Gradients of Brain Organization: Smooth Sailing from Methods Development to User Community

Neuroinformatics, Год журнала: 2024, Номер unknown

Опубликована: Апрель 3, 2024

Язык: Английский

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Genetic and phenotypic similarity across major psychiatric disorders: a systematic review and quantitative assessment

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Март 30, 2024

Язык: Английский

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Bridging the gap: improving correspondence between low-field and high-field magnetic resonance images in young people

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Фев. 23, 2024

Portable low-field-strength magnetic resonance imaging (MRI) systems represent a promising alternative to traditional high-field-strength with the potential make MR technology available at scale in low-resource settings. However, lower image quality and resolution may limit research clinical of these devices. We tested two super-resolution methods enhance low-field system compared their correspondence images acquired from high-field sample young people.

Язык: Английский

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Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 12, 2024

Abstract Alzheimer’s disease (AD) is a brain network disorder where pathological proteins accumulate through networks and drive cognitive decline. Yet, the role of connectivity in facilitating this accumulation remains unclear. Using in-vivo multimodal imaging, we show that distribution tau reactive microglia humans follows spatial patterns variation, so-called gradients organization. Notably, less distinct (“gradient contraction”) are associated with decline regions greater tau, suggesting an interaction between reduced differentiation on cognition. Furthermore, by modeling subject-specific gradient space, demonstrate frontoparietal temporo-occipital cortices baseline within their functionally structurally connected hubs, respectively. Our work unveils for both functional structural organization pathology AD, supports space as promising tool to map progression.

Язык: Английский

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Neuroimaging epicenters as potential sites of onset of the neuroanatomical pathology in schizophrenia

Science Advances, Год журнала: 2024, Номер 10(24)

Опубликована: Июнь 12, 2024

Schizophrenia lacks a clear definition at the neuroanatomical level, capturing sites of origin and progress this disorder. Using network-theory approach called epicenter mapping on cross-sectional magnetic resonance imaging from 1124 individuals with schizophrenia, we identified most likely "source origin" structural pathology. Our results suggest that Broca's area adjacent frontoinsular cortex may be epicenters pathophysiology in schizophrenia. These can predict an individual's response to treatment for psychosis. In addition, cross-diagnostic similarities based over 4000 diagnosed neurological, neurodevelopmental, or psychiatric disorders appear limited. When present, these are restricted bipolar disorder, major depressive obsessive-compulsive We provide comprehensive framework linking schizophrenia-specific multiple levels neurobiology, including cognitive processes, neurotransmitter receptors transporters, human brain gene expression. Epicenter reliable tool identifying potential onset neural

Язык: Английский

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