ACS Nano,
Год журнала:
2023,
Номер
17(20), С. 20073 - 20086
Опубликована: Окт. 4, 2023
Despite
the
potential
indicating
role
of
tyrosinase
(TYR)
in
cutaneous
melanoma,
how
to
capture
real
changes
TYR
suspicious
skin
remains
a
major
challenge.
Unlike
traditional
human
serum
test,
this
study
reports
sensing
platform
that
incorporates
wearable
microneedle
(MN)
patch
and
trimetallic
Au@Ag-Pt
nanoparticles
(NPs)
for
surface-enhanced
Raman
scattering
(SERS)
colorimetric
dual-mode
detecting
situ
toward
melanoma
screening.
In
presence
TYR,
catechol
immobilized
on
MN
is
preferentially
oxidized
benzoquinone,
which
competitively
impedes
interaction
NPs,
triggering
SERS-colorimetric
signal
reciprocal
switch.
Using
B16F10
mouse
model,
our
capable
noninvasively
piercing
surface
levels
before
during
anti-PD-1
antibody
treatment,
would
be
highly
informative
prognostic
judgment
illness
monitoring
melanoma.
Through
capturing
metabolic
advance,
was
successfully
applied
discriminate
subjects
from
moles
normal
ones
(p
<
0.001),
as
well
screen
lactate
dehydrogenase
(LDH)-negative
patients.
Melanoma
growth
prognosis
can
still
monitored
through
recording
continuous
change
levels.
More
importantly,
well-defined
flexible
stretchable
characteristics
allow
robustly
adhering
without
inducing
chemical
or
physical
irritation.
We
believe
integrating
MN-based
sensing,
responsiveness,
SERS/colorimetric
dual-readout
strategy
will
have
high
clinical
importance
early
diagnosis
Bioelectronic Medicine,
Год журнала:
2023,
Номер
9(1)
Опубликована: Авг. 2, 2023
The
fourth
industrial
revolution
has
led
to
the
development
and
application
of
health
monitoring
sensors
that
are
characterized
by
digitalization
intelligence.
These
have
extensive
applications
in
medical
care,
personal
management,
elderly
sports,
other
fields,
providing
people
with
more
convenient
real-time
services.
However,
these
face
limitations
such
as
noise
drift,
difficulty
extracting
useful
information
from
large
amounts
data,
lack
feedback
or
control
signals.
artificial
intelligence
provided
powerful
tools
algorithms
for
data
processing
analysis,
enabling
intelligent
monitoring,
achieving
high-precision
predictions
decisions.
By
integrating
Internet
Things,
intelligence,
sensors,
it
becomes
possible
realize
a
closed-loop
system
functions
collection,
online
diagnosis,
treatment
recommendations.
This
review
focuses
on
healthcare
enhanced
technologies
aspects
materials,
device
structure,
integration,
scenarios.
Specifically,
this
first
introduces
great
advances
wearable
respiration
rate,
heart
pulse,
sweat,
tears;
implantable
cardiovascular
nerve
signal
acquisition,
neurotransmitter
monitoring;
soft
electronics
precise
therapy.
Then,
recent
volatile
organic
compound
detection
highlighted.
Next,
current
developments
human-machine
interfaces,
AI-enhanced
multimode
self-sustainable
systems
reviewed.
Last,
perspective
future
directions
further
research
is
also
provided.
In
summary,
fusion
will
provide
intelligent,
convenient,
secure
services
next-generation
biomedical
applications.
Advanced Materials,
Год журнала:
2024,
Номер
36(52)
Опубликована: Март 22, 2024
Abstract
Triboelectric
nanogenerator
(TENG)
manifests
distinct
advantages
such
as
multiple
structural
selectivity,
diverse
selection
of
materials,
environmental
adaptability,
low
cost,
and
remarkable
conversion
efficiency,
which
becomes
a
promising
technology
for
micro‐nano
energy
harvesting
self‐powered
sensing.
Tribo‐dielectric
materials
are
the
fundamental
core
components
high‐performance
TENGs.
In
particular,
charge
generation,
dissipation,
storage,
migration
dielectrics,
dynamic
equilibrium
behaviors
determine
overall
performance.
Herein,
comprehensive
summary
is
presented
to
elucidate
dielectric
transport
mechanism
tribo‐dielectric
material
modification
principle
toward
The
contact
electrification
started
first,
followed
by
introducing
basic
Subsequently,
mechanisms
strategies
highlighted
regarding
physical/chemical,
surface/bulk,
coupling,
structure
optimization.
Furthermore,
representative
applications
based
TENGs
power
sources,
sensors
demonstrated.
existing
challenges
potential
opportunities
advanced
outlined,
guiding
design,
fabrication,
materials.
Advanced Materials,
Год журнала:
2023,
Номер
35(47)
Опубликована: Авг. 7, 2023
Chronic
wounds
have
become
a
significant
threat
to
people's
physical
and
mental
health
increased
the
burden
of
social
medical
care.
Intelligent
wound
dressing
(IWD)
with
condition
monitoring
closed-loop
on-demand
drug
therapy
can
shorten
healing
process
alleviate
patient
suffering.
However,
single-function
dressings
cannot
meet
current
needs
chronic
treatment.
Here,
wearable
IWD
consisting
exudate
management,
sensor
monitoring,
therapy,
flexible
circuit
modules
is
reported,
which
achieve
effective
synergy
between
management
therapy.
The
attached
site,
spontaneously
pumped
into
microfluidic
channel
for
storage.
Meanwhile,
detect
state
through
temperature
humidity
sensor,
use
this
as
feedback
control
liquid
metal
(LM)
heater
smartphone,
thereby
realizing
release
from
hydrogel.
In
mouse
model
infected
wounds,
accelerates
by
reducing
inflammatory
responses,
promoting
angiogenesis
collagen
deposition.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(28)
Опубликована: Фев. 7, 2024
Abstract
The
integration
of
real‐time
monitoring
and
on‐demand
treatment
has
substantial
potential
to
accelerate
wound
healing
processes.
In
this
context,
versatile
bilayer
microneedles
(MNs)
a
triboelectric
nanogenerator
(TENG)
are
developed
as
theranostic
platform
for
efficient
management.
This
provides
benefits
including
controlling
infection,
promoting
cell
migration
proliferation,
the
capability
biochemical
sensing.
MNs
comprise
solvable
polyvinylpyrrolidone
MN
(pMN)
affixed
atop
conductive
stainless‐steel
(sMN).
robust
sMN
penetrates
requisite
skin
depth,
while
pMN,
infused
with
antibiotics,
ensures
sustained
drug
release
upon
dissolution
in
interstitial
fluids.
Concurrently,
TENG
generates
electrical
stimulation
transmitted
site
through
sMN,
contributing
accelerated
closure.
Furthermore,
coated
silver
carbon
nanotubes
(CNT/Ag/sMN),
functions
transdermal
electrochemical
sensor
assess
state
by
detecting
hydrogen
peroxide
uric
acid.
Notably,
vivo
animal
studies
have
demonstrated
that
MN‐TENG
device
not
only
effectively
inhibits
bacterial
growth
expedites
but
also
monitors
biomarkers,
thereby
validating
its
utility
improving
infected
recovery.
Consequently,
based
strategy
fosters
advancements
diagnostic
therapeutic
technologies
within
management
related
biomedical
domains.
Advanced Materials,
Год журнала:
2024,
Номер
36(15)
Опубликована: Янв. 10, 2024
Abstract
Topical
therapy
is
a
favored
route
for
treating
skin
cancers,
but
remain
many
challenges,
such
as
low
delivery
efficiency,
limited
tumor
tissue
penetration,
and
unsatisfactory
blood
circulation.
Here,
self‐heating
microneedle
(MN)
patch
with
multilevel
structures,
including
dissolvable
base
rapid
drug
release,
degradable
tip
sustained
substrate
described.
The
thermally
enhanced
release
performance
validated
through
both
in
vitro
vivo
experiments.
High
therapeutic
efficacy
can
be
achieved
due
to
the
of
5‐fluorouracil,
while
thymoquinone
endows
MN
long‐term
inhibition
ability.
It
further
demonstrated
feasibility
an
topical
cutaneous
squamous
cell
carcinoma
high
efficacy,
side
effects,
recurrence.
This
holds
great
promise
potential
clinical
applications,
especially
treatment
cancers.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(24)
Опубликована: Фев. 20, 2024
Abstract
Every
year,
over
12
million
people
are
enduring
the
persistent
pain
resulting
from
wound
infections.
In
these
chronic
wounds,
concealed
infections
may
be
covered
up
by
scabs
or
granulation,
which
impeding
accurate
diagnosis
and
treatment.
To
address
such
clinical
challenges,
inspired
corals,
a
biomimetic
microneedle
patch
(HepMi‐PCL)
is
developed
to
indicate
treat
within
wound.
Relying
on
high‐precision
3D
printing
technology,
each
polycaprolactone
own
an
equally
sized
porous
shell
cavity
with
heparin‐based
functional
hydrogel
filling
in.
After
penetrating
through
scab,
HepMi‐PCL
can
absorb
exudate
in
surficial
guide
grooves
pores
microstructure
its
microneedle,
thereby
indicating
whether
anti‐infection
needed.
Upon
identification
of
positive
infection,
will
smartly
activate
release
drugs
rapidly.
Subsequently,
when
infection
effectively
managed
progressively
decreases,
drug
delivery
correspondingly
slow
down
cease
altogether.
By
leveraging
autonomous
response
therapeutic
capabilities,
demonstrates
potential
expedite
treatment
infections,
enhancement
healing
speed
for
infected
wounds
200%.
Thus,
integration
diagnostic
functions
anticipated
offer
novel
approaches
addressing
management
wounds.
Advanced Materials,
Год журнала:
2024,
Номер
36(16)
Опубликована: Янв. 12, 2024
Abstract
Polymers
are
playing
important
roles
in
the
rapid
development
of
triboelectric
nanogenerators
(TENGs);
However,
most
polymers
cannot
meet
high
requirements
thermomechanical
performance;
Thus,
various
polymeric
composites
developed
for
layer.
These
hardly
recycled
since
their
reinforcements
unevenly
distributed
after
reprocessing,
which
limits
sustainable
TENGs.
To
solve
above
challenges,
situ
generated
nanofiber
reinforced
(NFRCs)
based
on
single‐component
liquid
crystal
polyarylate
(LCP)
designed
and
prepared
via
a
one‐step
polycondensation.
Nonlinear
naphthalene
(NDA)
widens
processing
window
LCP
without
destabilizing
phase.
The
NDA‐rich
domains
act
as
matrix
while
NDA‐poor
with
higher
rigidity
form
oriented
nanofibers
to
achieve
self‐reinforcement.
resultant
NFRCs
possess
glass
transition
temperature
(
T
g
>
220
°C)
storage
modulus
E
′
=
0.1
GPa
at
350
°C),
far
beyond
existing
polymers,
typically
<
110
°C
MPa
(flowable)
°C.
Furthermore,
NFRC‐based
TENG
exhibits
superior
electrical
output
performance
retention
rate
(>90%)
reprocessing;
Overall,
this
work
offers
new
design
principle
prepare
self‐reinforced
composites,
paves
way
explore
materials.
