Food Science of Animal Products,
Год журнала:
2024,
Номер
2(2), С. 9240061 - 9240061
Опубликована: Июнь 1, 2024
Exercise-induced
fatigue
(EF)
refers
to
the
physiological
processes
that
impair
body's
ability
maintain
desired
levels
of
functioning
and
sustain
predetermined
exercise
intensity.
It
encompasses
peripheral
discomfort
(e.g.,
muscle
soreness,
weakness)
central
exhaustion,
characterized
by
emotional
sleep
disturbances.
The
detrimental
effects
EF
significantly
impact
human
productivity
lifestyle.
Given
crosstalk
between
gut
microbiota
metabolism
in
exercise,
there
is
a
growing
interest
investigating
role
elucidating
mechanisms
underlying
EF.
Furthermore,
exploring
dietary
interventions
as
novel
approach
alleviate
has
gained
attention.
Our
work
comprehensively
synthesizes
alterations
community
structure
function
caused
EF,
evaluates
existing
evidence
on
potential
probiotics
regulation
This
review
aims
enhance
our
understanding
correlation
microbiome
explores
use
mitigating
Nature Metabolism,
Год журнала:
2024,
Номер
6(10), С. 1856 - 1865
Опубликована: Авг. 20, 2024
Application
of
the
physical
laws
energy
and
mass
conservation
at
whole-body
level
is
not
necessarily
informative
about
causal
mechanisms
weight
gain
development
obesity.
The
balance
model
(EBM)
carbohydrate-insulin
(CIM)
are
two
plausible
theories,
among
several
others,
attempting
to
explain
why
obesity
develops
within
an
overall
common
physiological
framework
regulation
human
metabolism.
These
models
have
been
used
pathogenesis
in
individuals
as
well
dramatic
increases
prevalence
worldwide
over
past
half
century.
Here,
we
summarize
outcomes
a
recent
workshop
Copenhagen
that
brought
together
experts
from
around
world
discuss
pathogenesis.
discussions
helped
operationally
define
commonly
terms;
delineate
structure
each
model,
particularly
focussing
on
areas
overlap
divergence;
challenge
ideas
importance
purported
factors
for
gain;
brainstorm
key
scientific
questions
need
be
answered.
We
hope
more
experimental
research
nutrition
other
related
fields,
testing
their
predictions
will
pave
way
provide
answers
than
those
currently
available.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Май 28, 2024
Abstract
The
gut
microbiome
(GM)
modulates
body
weight/composition
and
gastrointestinal
functioning;
therefore,
approaches
targeting
resident
microbes
have
attracted
considerable
interest.
Intermittent
fasting
(IF)
protein
pacing
(P)
regimens
are
effective
in
facilitating
weight
loss
(WL)
enhancing
composition.
However,
the
interrelationships
between
IF-
P-induced
WL
GM
unknown.
current
randomized
controlled
study
describes
distinct
fecal
microbial
plasma
metabolomic
signatures
combined
IF-P
(
n
=
21)
versus
a
heart-healthy,
calorie-restricted
(CR,
20)
diet
matched
for
overall
energy
intake
free-living
human
participants
(women
27;
men
14)
with
overweight/obesity
8
weeks.
Gut
symptomatology
improves
abundance
of
Christensenellaceae
circulating
cytokines
amino
acid
metabolites
favoring
fat
oxidation
increase
(p
<
0.05),
whereas
associated
longevity-related
metabolic
pathway
CR
0.05).
Differences
indicate
factors
play
role
maintenance
This
novel
work
provides
insight
into
profile
following
an
or
highlights
important
differences
assembly
composition
responsiveness.
These
data
may
inform
future
GM-focused
precision
nutrition
recommendations
using
larger
sample
sizes
longer
duration.
Trial
registration,
March
6,
2020
(ClinicalTrials.gov
as
NCT04327141),
based
on
previous
intervention
trial.
Gastrointestinal Disorders,
Год журнала:
2025,
Номер
7(1), С. 7 - 7
Опубликована: Янв. 15, 2025
The
human
microbiome,
a
complex
ecosystem
of
microorganisms
residing
in
and
on
the
body,
plays
pivotal
role
regulation
wide
range
physiological
processes,
including
digestion,
immune
responses,
metabolic
functions.
In
recent
years,
rapidly
growing
field
microbiome-driven
therapeutics
has
garnered
significant
attention
owing
to
its
potential
revolutionize
healthcare.
This
review
explores
evolving
landscape
microbiome-based
therapies,
with
particular
focus
gut
microbiome
implications
for
both
health
precision
medicine.
We
highlight
advances
understanding
how
microbial
communities
influence
disease
pathogenesis
treatment
outcomes,
spanning
conditions
such
as
inflammatory
bowel
(IBD),
disorders,
neurological
diseases,
even
cancer.
article
also
discusses
emerging
therapeutic
strategies,
probiotics,
prebiotics,
fecal
microbiota
transplantation
(FMT),
microbial-based
drugs,
well
challenges
associated
their
clinical
implementation.
Additionally,
we
examined
integration
profiling
metagenomic
data
is
advancing
medicine,
paving
way
personalized
effective
treatments.
serves
comprehensive
resource
that
synthesizes
current
knowledge,
identifies
key
gaps
research,
offers
insights
into
future
direction
therapeutics,
thus
providing
valuable
framework
clinicians,
researchers,
policymakers
seeking
harness
microbiomes
advance
healthcare
solutions.
Industrialization
adversely
affects
the
gut
microbiome
and
predisposes
individuals
to
chronic
non-communicable
diseases.
We
tested
a
restoration
strategy
comprising
diet
that
recapitulated
key
characteristics
of
non-industrialized
dietary
patterns
(restore
diet)
bacterium
rarely
found
in
industrialized
microbiomes
(Limosilactobacillus
reuteri)
randomized
controlled
feeding
trial
healthy
Canadian
adults.
The
restore
diet,
despite
reducing
diversity,
enhanced
persistence
L.
reuteri
strain
from
rural
Papua
New
Guinea
(PB-W1)
redressed
several
features
altered
by
industrialization.
also
beneficially
microbiota-derived
plasma
metabolites
implicated
etiology
Considerable
cardiometabolic
benefits
were
observed
independently
administration,
which
could
be
accurately
predicted
baseline
diet-responsive
features.
findings
suggest
intervention
targeted
toward
restoring
can
improve
host-microbiome
interactions
likely
underpin
pathologies,
guide
recommendations
development
therapeutic
nutritional
strategies.
Nutrients,
Год журнала:
2024,
Номер
16(22), С. 3806 - 3806
Опубликована: Ноя. 6, 2024
Recent
studies
have
shown
a
growing
interest
in
the
complex
relationship
between
human
gut
microbiota,
metabolism,
and
overall
health.
This
review
aims
to
explore
microbiota-host
association,
focusing
on
its
implications
for
precision
nutrition
personalized
medicine.
The
objective
is
highlight
how
microbiota
modulate
metabolic
immune
functions,
contributing
disease
susceptibility
wellbeing.
synthesizes
recent
research
findings,
analyzing
key
influence
of
lipid
carbohydrate
intestinal
health,
neurobehavioral
regulation,
endocrine
signaling.
Data
were
drawn
from
both
experimental
clinical
trials
examining
interactions
relevant
nutrition.
Our
findings
essential
role
microbiota-derived
metabolites
regulating
host
including
glucose
pathways.
These
been
found
responses
barrier
integrity.
Additionally,
impacts
broader
physiological
processes,
neuroendocrine
which
could
be
crucial
dietary
interventions.
Therefore,
understanding
molecular
mechanisms
dietary-microbiota-host
pivotal
advancing
strategies.
Tailored
recommendations
based
individual
compositions
hold
promise
improving
health
outcomes,
potentially
revolutionizing
future
healthcare
approaches
across
diverse
populations.
