Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Март 25, 2025
Introduction
Ulcerative
colitis
(UC)
is
characterized
by
chronic
inflammation
and
ulceration
in
colonic
mucosa,
accompanied
a
defective
epithelial
barrier.
Proteus
mirabilis
(
P.
)
bacterium
putative
intestinal
pathogen
with
invasive
ability,
yet
its
role
UC
gut
barrier
disruption
unclear.
This
study
aims
to
investigate
epidemiological
presence,
pathogenic
roles
preventive
strategy
during
inflammation.
Method
culture
PCR
amplification
of
the
-specific
ureR
gene
were
used
detect
fecal
determine
prevalence
control
stool
specimens.
isolated
from
specimens
was
gavaged
into
dextran
sulfate
sodium
(DSS)-treated
mice.
Inflammation
mucus
layer
colons
assessed
through
histological
examination
cytokine
quantification.
Bacteriophages
screened
eliminate
animals.
Results
discussion
The
bacteria
detected
gene.
Of
41
patients,
65.9%
patients
positive,
which
significantly
higher
than
controls.
Administration
aggravated
DSS-induced
symptom
mucosal
Interestingly,
layer,
an
essential
component
barrier,
animals
dramatically
disrupted,
consistent
alteration
human
colon.
disrupted
mediated
down-regulation
IL-18
epithelium.
Importantly,
bacteriophage
cocktail
targeting
could
restore
alleviate
enteric
Thus,
our
results
suggest
that
pathobiont
bacterium,
exacerbates
severity
owing
mucin
production
expression.
Bacteriophage-mediated
elimination
may
be
effective
limiting
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117302 - 117302
Опубликована: Авг. 19, 2024
Inflammatory
bowel
disease
(IBD),
including
Crohn's
and
ulcerative
colitis,
is
a
complex
disorder
with
an
unknown
cause.
However,
the
dysbiosis
of
gut
microbiome
has
been
found
to
play
role
in
IBD
etiology,
exacerbated
immune
responses
defective
intestinal
barrier
integrity.
The
can
also
be
potential
biomarker
for
several
diseases,
IBD.
Currently,
conventional
treatments
targeting
pro-inflammatory
cytokines
pathways
IBD-associated
do
not
yield
effective
results.
Other
therapies
that
directly
target
dysbiotic
outcomes
are
emerging.
We
review
health
its
as
diagnostic,
prognostic,
therapeutic
This
explores
emerging
advancements
microbiome-associated
alterations
IBD,
such
nanoparticle
or
encapsulation
delivery,
fecal
microbiota
transplantation,
nutritional
therapies,
microbiome/probiotic
engineering,
phage
therapy,
mesenchymal
stem
cells
(MSCs),
proteins,
herbal
formulas.
Expert Review of Gastroenterology & Hepatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
The
gut
microbiota
has
a
complex
relationship
with
the
human
host
and
is
key
to
maintaining
health.
Disruption
of
healthy
diverse
microbial
milieu
plays
an
important
role
in
pathogenesis
several
diseases
including
Infection and Drug Resistance,
Год журнала:
2024,
Номер
Volume 17, С. 1107 - 1119
Опубликована: Март 1, 2024
Abstract:
Infections
with
drug-resistant
bacteria
have
become
one
of
the
greatest
public
health
challenges,
and
K.
pneumoniae
is
among
top
six
bacteria.
often
causes
nosocomial
infections,
leading
to
illnesses
such
as
pneumonia,
liver
abscesses,
soft
tissue
urinary
tract
bacteremia,
in
some
cases
death.
As
pathogen
continues
evolve
its
multidrug
resistance
increases,
poses
a
direct
threat
humans.
Drug
may
occur
due
formation
biofilms,
efflux
pumps,
production
β-lactamases.
In
many
cases,
further
enhanced
by
enzymatic
modification
loss
porins.
has
led
decline
effectiveness
conventional
therapies
against
this
pathogen.
Therefore,
there
an
urgent
need
accelerate
development
new
antibiotics
explore
therapeutic
approaches
antimicrobial
peptides,
phages,
traditional
Chinese
medicine,
immunotherapy,
Antimicrobial
nanoparticle
technology,
antisense
oligonucleotides
gene
editing
technologies.
review,
we
discuss
mechanisms
drug
compare
several
potential
strategies
overcome
treatment
infections.
Keywords:
Klebsiella
,
antibiotic
mechanisms,
The Lancet Microbe,
Год журнала:
2024,
Номер
5(5), С. e489 - e499
Опубликована: Март 4, 2024
Colonisation
by
bacterial
pathogens
typically
precedes
invasive
infection
and
seeds
transmission.
Thus,
effective
decolonisation
strategies
are
urgently
needed.
The
literature
reports
attempts
to
use
phages
for
decolonisation.
To
assess
the
in-vivo
efficacy
safety
of
decolonisation,
we
performed
a
systematic
review
identifying
relevant
studies
We
searched
PubMed,
Embase
(Ovid),
MEDLINE
Web
Science,
Cochrane
Library
identify
articles
published
between
Jan
1,
1990,
May
12,
2023,
without
language
restrictions.
included
that
assessed
phage
in
humans
or
vertebrate
animal
models.
This
is
registered
with
PROSPERO,
CRD42023457637.
identified
6694
articles,
which
56
(51
five
clinical
reports)
met
predetermined
selection
criteria
were
final
analysis.
gastrointestinal
tract
(n=49,
88%)
was
most
studied
colonisation
site,
other
sites
central
venous
catheters,
lung,
nose,
skin,
urinary
tract.
Of
studies,
load
at
site
reported
decrease
significantly
45
(80%)
but
only
described
eradication
target
bacteria.
15
No
obvious
adverse
events
both
short-term
long-term
observation
period.
Given
increasing
life-threatening
risks
posed
bacteria
difficult
treat,
could
be
an
alternative
option
although
further
optimisation
required
before
their
application
meet
needs.
Liver International,
Год журнала:
2025,
Номер
45(4)
Опубликована: Март 14, 2025
ABSTRACT
Background
and
Aims
Primary
sclerosing
cholangitis
(PSC)
is
an
immune‐related
cholangiopathy
without
treatment
options
beyond
liver
transplantation.
The
gut–liver
axis,
especially
the
role
of
gut
microbes,
has
emerged
as
a
crucial
pathway
contributing
to
PSC
pathogenesis.
Recent
research
revealed
Enterococcus
(E.)
faecalis
its
virulence
factor
cytolysin
increase
mortality
risk
in
patients
with
alcohol‐associated
hepatitis.
Thus,
we
studied
enterococci,
particularly
E.
genes
gelatinase,
faecal
samples
from
PSC.
Methods
To
assess
relevance
species,
performed
16S
rRNA
gene
amplicon
analysis
60
We
validated
our
findings
by
qPCR
microbial
DNA
extended
cohort
105
PSC,
104
inflammatory
bowel
disease
(IBD)
68
healthy
subjects.
Results
High‐throughput
increased
relative
abundance
enterococci
compared
controls
IBD
patients,
respectively,
(
p
<
0.0001).
high
had
decreased
probability
transplant‐free
survival
=
0.028).
factors
gelatinase
were
more
abundant
Higher
was
associated
lower
overall
0.04),
while
independent
levels.
Conclusion
Our
data
highlight
association
These
should
prompt
further
into
pathogenic
cytolysin‐positive
,
explore
potential
therapeutic
target.
JHEP Reports,
Год журнала:
2023,
Номер
5(12), С. 100909 - 100909
Опубликована: Сен. 23, 2023
Phage
therapy
has
been
overshadowed
by
antibiotics
for
decades.
However,
it
is
being
revisited
as
a
powerful
approach
against
antimicrobial-resistant
bacteria.
As
bacterial
microbiota
have
mechanistically
linked
to
gastrointestinal
and
liver
diseases,
precise
editing
of
the
gut
via
selective
bactericidal
action
phages
prompted
renewed
interest
in
phage
therapy.
In
this
review,
we
summarise
basic
virological
properties
latest
findings
on
composition
intestinal
phageome
changes
associated
with
diseases.
We
also
review
preclinical
clinical
studies
assessing
treatment
well
future
prospects
challenges.
