Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice

Nature Metabolism, Год журнала: 2024, Номер 6(8), С. 1601 - 1615

Опубликована: Июль 19, 2024

Язык: Английский

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Gut microbial features and circulating metabolomic signatures of frailty in older adults

Nature Aging, Год журнала: 2024, Номер 4(9), С. 1249 - 1262

Опубликована: Июль 25, 2024

Язык: Английский

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Excess fermentation and lactic acidosis as detrimental functions of the gut microbes in treatment-naive TB patients

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Фев. 19, 2024

Introduction The link between gut microbiota and host immunity motivated numerous studies of the microbiome in tuberculosis (TB) patients. However, these did not explore metabolic capacity community, which is a key axis impact on host’s immunity. Methods We used deep sequencing fecal samples from 23 treatment-naive TB patients 48 healthy donors to reconstruct microbiome’s strain/species-level content. Results show that systematic depletion commensal flora large intestine, Bacteroidetes , an increase Actinobacteria, Firmicutes Proteobacteria such as Streptococcaceae, Erysipelotrichaceae, Lachnospiraceae Enterobacteriaceae explains strong taxonomic divergence community cumulative expansion diverse disease-associated pathobionts reached 1/4 total microbiota, suggesting heavy toll along with MTB infection. Reconstruction pathways showed microbial shifted toward rapid growth using glycolysis excess fermentation produce acetate lactate. Higher glucose availability intestine likely drives lactate growth, causing acidosis endotoxemia. Discussion Excessive lactic characterize patients’ disturbed microbiomes. Since strongly suppresses normal flora, directly interferes macrophage function, linked mortality patients, our findings highlight novel research focus. If confirmed, may be potential host-directed treatment target augment traditional treatment.

Язык: Английский

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A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules

Cell Host & Microbe, Год журнала: 2025, Номер 33(2), С. 218 - 234.e12

Опубликована: Фев. 1, 2025

Язык: Английский

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A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 8, 2024

Abstract Changes in the gut microbiome have been associated with several human diseases, but molecular and functional details underlying these associations remain largely unknown. Here, we performed a multi-cohort analysis of small molecule biosynthetic gene clusters (BGCs) 5,306 metagenomic samples from 2,033 Inflammatory Bowel Disease (IBD) patients 833 matched healthy subjects identified group Clostridia-derived BGCs that are significantly IBD. Using synthetic biology, discovered solved structures six fatty acid amides as products IBD-enriched BGCs. two mouse models colitis, show molecules disrupt permeability exacerbate inflammation chemically genetically susceptible mice. These findings suggest microbiome-derived may play role etiology IBD represent generalizable approach for discovering mediators microbiome-host interactions context microbiome-associated diseases.

Язык: Английский

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Pre-exposure of abundant species to disturbance improves resilience in microbial metacommunities

Nature Ecology & Evolution, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Язык: Английский

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A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple continents, age groups, and body sites

Cell Systems, Год журнала: 2025, Номер 16(2), С. 101196 - 101196

Опубликована: Фев. 1, 2025

Язык: Английский

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Funktionelle Charakterisierung unbekannter Proteasen des Mikrobioms

BIOspektrum, Год журнала: 2025, Номер 31(1), С. 40 - 43

Опубликована: Фев. 1, 2025

Язык: Английский

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MMINT: A Metabolic Model Interactive Network Tool for the Exploration and Comparative Visualisation of Metabolic Networks

Опубликована: Янв. 1, 2025

Язык: Английский

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Biombalance™, an Oligomeric Procyanidins-Enriched Grape Seed Extract, Prevents Inflammation and Microbiota Dysbiosis in a Mice Colitis Model

Antioxidants, Год журнала: 2025, Номер 14(3), С. 305 - 305

Опубликована: Март 1, 2025

Inflammatory bowel disease (IBD) results from genetic factors, environmental and intestinal microbiota interactions. This study investigated the effects of Biombalance™ (BB) in dextran sulphate sodium (DSS)-induced colitis mice. BB extract exhibits high antioxidant activity, as determined by DPPH ORAC tests. Mice were fed a standard diet, was administered gavage for ten days, before administration 2.75% DSS drinking water. significantly protected mice against effects, assessed colon length, activity index (DAI) scores colonic pathological damage. In addition, inhibited expression proinflammatory markers, such IL-6, IL-17, CXCL1 TNF-α, inflammatory mediators iNOS, TGF-β, FoxP3 F4/80, while increasing IL-10 colon. modified composition, attenuating microbial diversity lost due to DSS, beneficial bacteria like Muribaculum, Lactobacillus, Muscispirillum, Roseburia Bifidobacterium, decreasing potentially harmful Proteobacteria Enterococcus. Interestingly, microbiota-predicted functions using PICRUSt revealed that increases superpathway ubiquinol biosynthesis, including ubiquinol-7, 8, 9 10 (CoenzymesQ). These findings suggest may help reduce gut inflammation oxidation, at least partly through modifications its metabolites.

Язык: Английский

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