Journal of Multidisciplinary Healthcare,
Год журнала:
2024,
Номер
Volume 17, С. 5117 - 5137
Опубликована: Ноя. 1, 2024
Cancer
poses
a
major
global
health
challenge,
and
immunotherapy,
known
as
the
third
revolution
in
cancer
treatment,
has
brought
new
hope
to
patients.
The
emerging
field
of
immunometabolism
further
enhanced
safety
efficacy
immunotherapy.
Over
past
two
decades,
this
rapidly
evolved
oncology,
leading
numerous
significant
findings.
This
review
systematically
examines
literature
on
cancer,
visualizing
research
trends
identifying
future
directions.
Molecular Medicine,
Год журнала:
2024,
Номер
30(1)
Опубликована: Ноя. 6, 2024
Abstract
Intestinal
ischemia/reperfusion
injury
(I/R)
is
a
common
yet
challenging-to-treat
condition,
presenting
significant
clinical
challenge.
This
study
aims
to
investigate
the
protective
mechanisms
of
Dexmedetomidine
(Dex)
against
I/R
injury,
with
particular
focus
on
its
role
in
regulating
autophagy
activity
intestinal
neurons
and
maintaining
mitochondrial
homeostasis.
Experimental
findings
demonstrate
that
Dex
can
mitigate
damage
induced
by
through
modulation
function
suppressing
expression
Nupr1.
discovery
sheds
light
new
molecular
mechanism
underlying
potential
efficacy
treating
offering
valuable
insights
for
therapy.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 15, 2024
Abstract
This
study
aimed
to
investigate
the
role
of
STING
(Stimulator
Interferon
Genes)
in
intestinal
ischemia-reperfusion
(IIR)
injury,
focusing
on
its
impact
mitochondrial
function,
pyroptosis,
and
inflammation.
The
utilized
both
vivo
vitro
models,
including
a
mouse
model
IIR
organoids
subjected
hypoxia-reoxygenation
(HR).
We
assessed
effects
pharmacological
inhibition
using
H.151
knockout
injury
markers,
histological
damage,
pro-inflammatory
cytokine
levels,
morphology
pyroptosis
markers.
Our
findings
revealed
that
significantly
upregulated
expression
epithelium,
coinciding
with
increased
permeability,
elevated
production
(IL-1β)
(p
<
0.05),
evidence
dysfunction,
characterized
by
reduced
ATP
disrupted
0.01).
Importantly,
treatment
attenuated
IIR-induced
damage
0.01),
levels
preserved
function
Furthermore,
we
observed
significant
reduction
as
evidenced
decreased
cleaved
gasdermin
D
H.151-treated
groups
0.05).
identifies
critical
mediator
likely
through
activation
pathways
leading
dysfunction
pyroptosis.
suggest
targeting
represents
promising
therapeutic
strategy
for
mitigating
following
ischemia-reperfusion.
Journal of Multidisciplinary Healthcare,
Год журнала:
2024,
Номер
Volume 17, С. 5117 - 5137
Опубликована: Ноя. 1, 2024
Cancer
poses
a
major
global
health
challenge,
and
immunotherapy,
known
as
the
third
revolution
in
cancer
treatment,
has
brought
new
hope
to
patients.
The
emerging
field
of
immunometabolism
further
enhanced
safety
efficacy
immunotherapy.
Over
past
two
decades,
this
rapidly
evolved
oncology,
leading
numerous
significant
findings.
This
review
systematically
examines
literature
on
cancer,
visualizing
research
trends
identifying
future
directions.
