International Immunopharmacology,
Journal Year:
2024,
Volume and Issue:
144, P. 113653 - 113653
Published: Nov. 19, 2024
Ankylosing
spondylitis
(AS)
is
a
motor
system
immune
disease
with
significant
genetic
characteristics,
resulting
in
joint
fusion,
deformity,
rigidity,
seriously
affecting
the
quality
of
life
patients.
Inflammatory
bowel
(IBD),
characterized
by
intestinal
mucosal
damage
and
inflammatory
changes,
most
common
extra-articular
manifestation
AS.
Due
to
limitations
application
therapeutic
drugs,
it
urgent
look
for
new
mechanisms
strategies
effectively
inhibit
AS
inflammation
is.
The
content
malic
acid
(MA)
was
significantly
decreased
peripheral
blood
patients,
negatively
correlated
C-reactive
protein
(CRP)
erythrocyte
sedimentation
rate
(ESR).
MA
dramatically
alleviated
spinal
mouse
models
induced
β-1,
3-glucan
solution.
Mechanically,
suppressed
NF-κB
pathway
inhibiting
polarization
M1-type
macrophages,
thereby
alleviating
inflammation.
From
perspective
material
metabolism,
this
study
explored
mechanism
which
MA,
an
intermediate
product
glucose
reducing
M1
macrophages
inflammation,
providing
reliable
basis
pathogenesis
research
precise
targeted
treatment
later
stage.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 15, 2024
Abstract
This
study
aimed
to
investigate
the
role
of
STING
(Stimulator
Interferon
Genes)
in
intestinal
ischemia-reperfusion
(IIR)
injury,
focusing
on
its
impact
mitochondrial
function,
pyroptosis,
and
inflammation.
The
utilized
both
vivo
vitro
models,
including
a
mouse
model
IIR
organoids
subjected
hypoxia-reoxygenation
(HR).
We
assessed
effects
pharmacological
inhibition
using
H.151
knockout
injury
markers,
histological
damage,
pro-inflammatory
cytokine
levels,
morphology
pyroptosis
markers.
Our
findings
revealed
that
significantly
upregulated
expression
epithelium,
coinciding
with
increased
permeability,
elevated
production
(IL-1β)
(p
<
0.05),
evidence
dysfunction,
characterized
by
reduced
ATP
disrupted
0.01).
Importantly,
treatment
attenuated
IIR-induced
damage
0.01),
levels
preserved
function
Furthermore,
we
observed
significant
reduction
as
evidenced
decreased
cleaved
gasdermin
D
H.151-treated
groups
0.05).
identifies
critical
mediator
likely
through
activation
pathways
leading
dysfunction
pyroptosis.
suggest
targeting
represents
promising
therapeutic
strategy
for
mitigating
following
ischemia-reperfusion.
Journal of Multidisciplinary Healthcare,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 5117 - 5137
Published: Nov. 1, 2024
Cancer
poses
a
major
global
health
challenge,
and
immunotherapy,
known
as
the
third
revolution
in
cancer
treatment,
has
brought
new
hope
to
patients.
The
emerging
field
of
immunometabolism
further
enhanced
safety
efficacy
immunotherapy.
Over
past
two
decades,
this
rapidly
evolved
oncology,
leading
numerous
significant
findings.
This
review
systematically
examines
literature
on
cancer,
visualizing
research
trends
identifying
future
directions.
International Immunopharmacology,
Journal Year:
2024,
Volume and Issue:
144, P. 113653 - 113653
Published: Nov. 19, 2024
Ankylosing
spondylitis
(AS)
is
a
motor
system
immune
disease
with
significant
genetic
characteristics,
resulting
in
joint
fusion,
deformity,
rigidity,
seriously
affecting
the
quality
of
life
patients.
Inflammatory
bowel
(IBD),
characterized
by
intestinal
mucosal
damage
and
inflammatory
changes,
most
common
extra-articular
manifestation
AS.
Due
to
limitations
application
therapeutic
drugs,
it
urgent
look
for
new
mechanisms
strategies
effectively
inhibit
AS
inflammation
is.
The
content
malic
acid
(MA)
was
significantly
decreased
peripheral
blood
patients,
negatively
correlated
C-reactive
protein
(CRP)
erythrocyte
sedimentation
rate
(ESR).
MA
dramatically
alleviated
spinal
mouse
models
induced
β-1,
3-glucan
solution.
Mechanically,
suppressed
NF-κB
pathway
inhibiting
polarization
M1-type
macrophages,
thereby
alleviating
inflammation.
From
perspective
material
metabolism,
this
study
explored
mechanism
which
MA,
an
intermediate
product
glucose
reducing
M1
macrophages
inflammation,
providing
reliable
basis
pathogenesis
research
precise
targeted
treatment
later
stage.
